Overview
The concept of the NOEL approach is, in itself, very simple. Many types of toxicology studies are performed utilizing a graded range of dose levels of test compound. The NOEL (No Observed Effect Level) is the highest dose level at which and below which no effects of the test compound are observed amongst the evaluated parameters. A refinement of this concept is the use of the NOAEL (No Observed Adverse Effect Level) which only takes into account effects which are regarded as adverse.
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References
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© 1995 Springer-Verlag Berlin Heidelberg
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Esdaile, D.J. (1995). Principles, Benefits and Limitations of the NOEL Approach. In: Degen, G.H., Seiler, J.P., Bentley, P. (eds) Toxicology in Transition. Archives of Toxicology, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79451-3_4
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DOI: https://doi.org/10.1007/978-3-642-79451-3_4
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