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The SCID (Severe Combined Immunodeficiency) Mouse — Its Biology and Use in Immunotoxicological Research

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Toxicology in Transition

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 17))

Abstract

In medical research, there is a need to bridge the gap between in vivo animal experimentation and studies on human cells and tissues in vitro. Two clefts have to be bridged — one is the species difference, the other is the in vivo — in vitro difference. The SCID mouse reconstituted with human cells may represent an important tool for building the bridges needed. Models based on reconstituted SCID mice make experimentation with human cells in an in vivo situation possible without the ethical and practical constraints that limit studies in man.

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Authors and Affiliations

  1. Section for Environmental Immunology, Department of Environmental Medicine, National Institute of Public Health, Oslo, Norway

    Martinus Løvik

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  1. Martinus Løvik
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  1. Institut für Arbeitsphysiologie an der Universität Dortmund, Ardeystr. 67, D-44139, Dortmund, Germany

    Gisela H. Degen

  2. Interkantonale Kontrollstelle für Heilmittel, Erlachstr. 8, CH-3000, Bern 9, Switzerland

    Jürg P. Seiler

  3. Ciba-Geigy Ltd., K-136.3.23, CH-4002, Basel, Switzerland

    Philip Bentley

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© 1995 Springer-Verlag Berlin Heidelberg

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Løvik, M. (1995). The SCID (Severe Combined Immunodeficiency) Mouse — Its Biology and Use in Immunotoxicological Research. In: Degen, G.H., Seiler, J.P., Bentley, P. (eds) Toxicology in Transition. Archives of Toxicology, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79451-3_39

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  • DOI: https://doi.org/10.1007/978-3-642-79451-3_39

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