Abstract
The development of transgenic animals has already had a significant impact in biomedical research. Non-human models of human diseases (i.e., sickle cell disease, cystic fibrosis and AIDS) have been produced in mice and are being used to screen potential therapies (Breslow, 1994). Domesticated animals genetically engineered to: (a) resist disease, (b) produce meat or eggs with less cholesterol, or (c) accelerate growth may be introduced into agriculture in the near future (Sedlak, 1989). Transgenic animals have also been proposed as living bioreactors for the commercial production of pharmaceuticals and other biologicals not easily synthesized by other methods (Van Brunt, 1988).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Breslow J (1994) Lipoproteins and heart disease. Bio/Technology 12:365–370
Camper SA (1987) Research applications of transgenic mice. Bio Techniques 5: 638–650
Genetic Engineering News, University Gen Beat, June 1, 1994
Gordon J, Scangos GA, Plotkin DJ, Barbosa JA, Ruddle F (1980) Genetic transformation of mouse embryos by microinjection of purified DNA. Proc. Natl. Acad. Sci. 77:7380–7384
Gossen J, Vijg J (1993) Transgenic mice as model systems for studying gene mutations in vivo. TIG 9:27–31
Jaenisch R (1976) Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus. Proc. Natl. Acad. Sci. 73:1260–1264
Kuehn MR, Bradley A, Robertson EJ, Evans MJ (1987) A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. Nature 326:295–298
Mark WH (1992) Manipulation of the mouse genome using embryonic stem cells. Lab Animal 21:41–53
Matsukuma S, Nakatsuru Y, Nakagawa K, Utakoji T, Sugano H, Kataoka H, Sekiguchi M, Ishikawa T (1989) Enhanced 06 -methylguanine-DNA methyltransferase activity in transgenic mice containing an integrated E. coli ada repair gene. Mutation Research 218:197–206
Raines LH (1988) The mouse that roared. Issues in Science and Technology 4:64–70
Saffer JD (1992) Transgenic mice in biomedical research. Lab Animal 21:30–38
Sanders B (1994) Stress proteins as molecular chaperons: implications for toxicology. Environmental Health Perspective 102:538–540
Sedlak BJ (1989) Transgenics enters commercial arena with high hopes for the 1990s. The Medical Business Journal 5:61,67–70
Shinkai Y, Rathbun G, Lam KP, Oltz EM, Stewart V, Mendesohn M, Charron J, Datta M, Young F, Stall AM, Alt FW (1992) RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 6:68
Storm EE, Huynh TV, Copeland NG, Jenkins NA, Kingsley DM, Lee S (1994) Limb alterations inbrachypodism mice due to mutations in a new member of the TGF-B- superfamily. Nature 368:639–642
Sullivan N, Gatehouse D, Tweats D (1993) Mutation, cancer and transgenic models: relevance to the toxicology industry. Mutagenesis 8:167–174
Van Brunt J (1990) Transgenics primed for research. Bio/Technology 8:725–728
Van Brunt J (1988) Molecular fanning: transgenic animals as bioreactors. Bio/Technology 6:1149–1154
Whiting S, Marshall H, Coole M, Krumlanf R, Rigby PWJ, Stott D, Allenmann RK (1991) Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression. Genes Dev. 5:2048–2059
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Brusick, D. (1995). Applications for Transgenic Animals in Toxicology. In: Degen, G.H., Seiler, J.P., Bentley, P. (eds) Toxicology in Transition. Archives of Toxicology, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79451-3_3
Download citation
DOI: https://doi.org/10.1007/978-3-642-79451-3_3
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-79453-7
Online ISBN: 978-3-642-79451-3
eBook Packages: Springer Book Archive