Role of Second Messengers in Mineral Particle-Induced Production of Reactive Oxygen Species by Phagocytes
Exposure to asbestos has been associated for a number of years with pulmonary diseases such as pulmonary fibrosis and carcinoma. Occupational exposure to chrysotile has been a frequent cause for lung carcinoma. More recently, also an association between exposure to quartz dust and increased risk of lung carcinoma has been found (Koskela et al. 1987). Exposure to both asbestos and quartz is associated also with an increased risk of lung fibrosis.
KeywordsNitric Oxide NADPH Oxidase Alveolar Macrophage Phorbol Myristate Acetate Phosphatidic Acid
Unable to display preview. Download preview PDF.
- Adamson IY, Bowden DH (1984) Relationship of alveolar epithelial injury and repair to induction of pulmonary fibrosis. Am J Pathol 130:377–383Google Scholar
- Chabot MC, McPhail C, Wykle RL, Kennerly AA, McCall CE (1992) Comparison of diglyceride production from choline-containing phosphoglycerides in human neutrophils stimulated with N- formylmethionyl-leucyphenylalanine, ionophore A23187 or phorbol 12-myristate 13-aeetate. Biochem J 286:693–699PubMedGoogle Scholar
- Ding J, Badwey JA (1993b) Stimulation of neutrophils with a chemoattractant activates several novel protein kinases that can catalyze the phosphorylation of peptides derived from the 47-kDa protein component of the phagocyte oxidase and myristoylated alanine-rich C kinase substrate. J Biol Chem 268:17326–17333PubMedGoogle Scholar
- Driscoll KE, Maurer JK, Lindenschmidt RC, Romberger D, Rennard SI, Crosby L (1990) Respiratory tract responses to dust: Relationship between dust burden, lung injury, alveolar macrophage fibronectin release, and the development of pulmonary fibrosis. Toxicol Appl Pharmacol 106:88–101PubMedCrossRefGoogle Scholar
- Kessels GC, Krause K-H, Verhoeven AJ (1993) Protein kinase C activity is not involved in N-formylmethionyl-leucyl-phenylalanine-induced phospholipase D activation in human neutrophils, but in essential for concomitant NADPH oxidase activation: studies with a staurosporine analogue with improved selectivity for protein kinase C. Biochem J 292:781–785PubMedGoogle Scholar
- Klockars M, Hedenborg M, Vanhala E (1990) Effect of two particle surface- modifying agents, polyvinylpyridine-N-oxide and carboxymethylcellulose, on the quartz and asbestos mineral fiber- induced production of reactive oxygen metabolites by human polymorphonuclear leukocytes. Arch Environ Health 45:8–14PubMedCrossRefGoogle Scholar
- Meshulam T, Diamond RD, Lyman CA, Wysong DR, Melnick DA (1988) Temporal association of calcium mobilization, inositol trisphosphate generation, and superoxide anion release by human neutrophils activated by serum opsonized and nonopsonized particulate stimuli. Biochem Biophys Res Commun 150:532–539PubMedCrossRefGoogle Scholar
- Nyberg P, Klockars M (1990a) Measurement of reactive oxygen metabolites produced by human monocyte-derived macrophages exposed to mineral dusts. Int J Exp Path 71:537–544Google Scholar
- Ruotsalainen M, Savolainen K (1994) Effects of a protein kinase C inhibitor, Ro 31–7549, on the activation of human leukocytes by particulate stimuli. Hum Exper Toxicol (in Press)Google Scholar
- Sadler KL, Badwey JA (1988) Second messengers involved in superoxide production byneutrophils. Hemat Oncol Clin North Am 2:185–200Google Scholar
- Seifert R, Schultz G (1991) The superoxide-forming NADPH oxidase of phagocytes: an enzyme system regulated by multiple mechanism. Reviews of Physiology, Biochemistry, and Pharmacology 117, Springer-Verlag, Heidelberg, p. 19Google Scholar