Molecular Genetic Studies of Atopic Allergy

  • D. G. Marsh
Conference paper


The atopic allergies are a group of complex diseases whose expression can involve the interaction of several different classes of genes as well as a myriad of environmental factors [19, 22]. The present review will emphasize particularly those genes that may play an important role in asthma.


Allergy Clin Immunol Atopic Disease Molecular Genetic Study Atopic Allergy Complex Segregation Analysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Bazaral M, Orgel HA, Hamburger RN (1974) Genetics of IgE and allergy: serum IgE levels in twins. J Allergy Clin Immunol 54: 288–304CrossRefGoogle Scholar
  2. 2.
    Blumenthal MN, Namboodiri K, Mendell N, Gleich G, Elston RC, Yunis E (1981) Genetic transmission of serum IgE levels. Am J Hum Genet 10: 219–228Google Scholar
  3. 3.
    Borecki IB, Rao DC, Lalouel JM, Gerrard JW (1985) Demonstration of a common major gene with pleiotropic effects on immunoglobulin E levels and allergy. Genetic Epidemiol 2: 327–338CrossRefGoogle Scholar
  4. 4.
    Buetow KH, Weber JL, Ludwigsen S et al (1994) Integrated human genomewide maps constructed using the CEPH reference panel. Nature Genet 6: 391–393PubMedCrossRefGoogle Scholar
  5. 5.
    Burrows B, Martinez ED, Halonen M, Barbee RA, Cline MG (1989) Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med 320: 271–277PubMedCrossRefGoogle Scholar
  6. 6.
    Cohen D, Chumakov I, Weissenbach J (1993) A first-generation physical map of the human genome. Nature 366: 698–701PubMedCrossRefGoogle Scholar
  7. 7.
    Freidhoff LR, Marsh DG (1993) The relationship among asthma, serum IgE levels and skin-test sensitivity to inhaled allergens. Int Arch Allergy Appl Immunol 100: 355–361CrossRefGoogle Scholar
  8. 8.
    Freidhoff LR, Meyers DA, Marsh DG (1984) A genetic—epidemiologic study of human immune responsiveness to allergens in an industrial population. II. The associations among skin sensitivity, total serum IgE, age and sex in a stratified random sample. J Allergy Clin Immunol 73: 490–499PubMedCrossRefGoogle Scholar
  9. 9.
    Gauchat J-F, Lebman DA, Coffman RL, Gascan H, De Vries JE (1990) Structure and expression of germline e transcripts in human B cells induced by interleukin 4 to switch to IgE production. J Exp Med 172: 463–473PubMedCrossRefGoogle Scholar
  10. 10.
    Gauchat J-F, Henchoz S, Mazzel G et al (1993) Induction of human IgE synthesis in B cells by mast cells and basophils. Nature 365: 340–343PubMedCrossRefGoogle Scholar
  11. 11.
    Gerrard JW, Rao DC, Morton NE (1978) A genetic study of immunoglobulin E. Am J Hum Genet 30: 46–58PubMedGoogle Scholar
  12. 12.
    Gyapay G, Morisette J, Vignal A et al (1994) The 1993–94 Généthon human genetic linkage map. Nature Genet 7: 246–339PubMedCrossRefGoogle Scholar
  13. 13.
    Hamburger RN, Orgel HA, Bazaral M (1973) Genetics of human IgE levels. In: Goodfriend L, Sehon AH, Orange RP (eds) Mechanisms in allergy: reaginmediated hypersensitivity. Dekker, New York, p 131Google Scholar
  14. 14.
    Hasstedt SJ, Meyers DA, Marsh DG (1983) The inheritance of immunoglobulin E: genetic model fitting. Am J Med Genet 14: 61–66PubMedCrossRefGoogle Scholar
  15. 15.
    Huang S-K, Marsh DG (1993) Genetics of allergic diseases. Ann Allergy 70: 347–359PubMedGoogle Scholar
  16. 16.
    Ishizaka K, Ishizaka T (1968) Human reaginic antibodies and immunoglobulin E. J Allergy 42: 330–363PubMedCrossRefGoogle Scholar
  17. 17.
    Johansson SGO, Bennich HH, Berg T (1972) The clinical significance of IgE. Prog Clin Immunol 1: 1–25Google Scholar
  18. 17.
    Johansson SGO, Bennich HH, Berg T (1972) The clinical significance of IgE. Prog Clin Immunol 1: 1–25Google Scholar
  19. 19.
    Marsh DG, Blumenthal MN (eds) (1990) Genetic and environmental factors in clinical allergy. University of Minnesota Press, MinneapolisGoogle Scholar
  20. 20.
    Marsh DG, Bias WB, Ishizaka K (1974) Genetic control of basal serum immunoglobulin E level and its effect on specific reaginic sensitivity. Proc Natl Acad Sci 9 (71): 3588–3592CrossRefGoogle Scholar
  21. 21.
    Marsh DG, Zwollo P, Huang S, Ghosh B, Ansari AA (1990) Molecular studies of human response to allergens. Cold Spring Harbor Symp Quant Biol 54: 459–470Google Scholar
  22. 22.
    Marsh DG, Lockhart A, Holgate SJ (eds) (1993) The genetics of asthma. Blackwell Scientific, OxfordGoogle Scholar
  23. 23.
    Marsh DG, Neely JD, Breazeale DR, Ghosh B, Freidhoff LR, Ehrlich-Kautzky E, Schou C, Krishnaswamy G, Beaty TH (1994) Linkage analysis of IL4and other chromosome 5g31.1 markers and total serum IgE concentrations. Science 264: 1152–1156PubMedCrossRefGoogle Scholar
  24. 24.
    Meyers DA, Beaty TH, Freidhoff LR, Marsh DG (1987) Inheritance of total serum IgE (basal levels) in man Am J Hum Genet 41: 51–62PubMedGoogle Scholar
  25. 25.
    Meyers DA, Bias WB, Marsh DG (1982) A genetic study of total IgE in the Amish. Hum Hered 32: 15–23PubMedCrossRefGoogle Scholar
  26. 26.
    Meyers DA, Hasstedt SJ, Marsh DG, Skolnick M, King MC, Bias WB, Amos DB (1983) The inheritance of immunoglobulin E: linkage analysis. Am J Med Genet 16: 575–581PubMedCrossRefGoogle Scholar
  27. 27.
    Meyers DA, Beaty TH, Colyer CR, Marsh DG (1991) Genetics of total serum IgE levels: a regressive model approach to segregation analysis. Genet Epidemiol 8: 351–359PubMedCrossRefGoogle Scholar
  28. 28.
    Mossman TR, Coffman RL (1989) Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv Immunol 46: 111–147CrossRefGoogle Scholar
  29. 29.
    Romagnani S (1991) Human Th1 and Th2: doubt no more. Immunol Today 12: 256–257PubMedCrossRefGoogle Scholar
  30. 30.
    Sears MR, Burrows B, Flannery EM, Herbison GP, Hewitt CJ, Holdaway MD (1991) Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children. N Engl J Med 325: 1067–1071PubMedCrossRefGoogle Scholar
  31. 31.
    Shirakawa T, Li A, Dubowitz M et al (1994) Association between atopy and variants of the 13 subunit of the high-affinity immunoglobulin E receptor. Nature Genet 7: 125–130PubMedCrossRefGoogle Scholar
  32. 32.
    Sporik R, Holgate ST, Platts-Mills TAE, Cogswell JJ (1990) Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood: a prospective study. N Engl J Med 323: 502–507PubMedCrossRefGoogle Scholar
  33. 33.
    Tollerud DJ, O’Connor GT, Sparrow D, Weiss ST (1991) Asthma, hay fever, and phlegm production associated with distinct patterns of allergy skin test reactivity, eosinophilia, and serum IgE levels. Am Rev Respir Dis 144: 776–781PubMedCrossRefGoogle Scholar
  34. 34.
    Weber JL, May PE (1989) Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. Am J Hum Genet 44: 388–396PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1995

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  • D. G. Marsh

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