Regulation of B Cell Switching to IgE

  • D. Vercelli
Conference paper


During an immune response, a B lymphocyte can express different immunoglobulin (Ig) heavy chain isotypes sharing the same VDJ region. This phenomenon (isotype switching) allows a single B cell clone to produce antibodies that retain variable region specificity in association with a different effector function. We shall herein focus on the molecular basis of switching to the IgE isotype, for two main reasons. First, elucidation of the mechanisms responsible for the choice of the IgE isotype is necessary to understand the pathophysiology of allergic disease. Furthermore, the signals required for isotype-specific switching are best understood in the IgE system. IgE isotype switching is therefore a general model for molecular studies of isotype switching.


Class Switch Recombination Cell Switching Germline Transcript Germline Transcription Variable Region Specificity 
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© Springer-Verlag Berlin Heidelberg 1995

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  • D. Vercelli

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