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Calcium and Cyclosporin A in the Regulation of Apoptosis

  • Chapter
Apoptosis in Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 200))

Abstract

Calcium concentration control is critical to cell viability and function. Energy-dependent Ca2+ transport systems located in the plasma membrane, endoplasmic reticulum, mitochondria, and nucleus maintain a cytosolic Ca2+ concentration (about 100 nM) that is roughly three orders of magnitude lower than that present in the extracellular millieu (about 1 mM). During cellular activation the presence of this gradient is exploited, and controlled elevations in the cytosolic Ca2+ level mediate the effects of hormones and other growth stimuli. However, damage to the cell can impair the proper function of Ca2+ homeostatic mechanisms and lead to uncontrolled, sustained Ca2+ increases that mediate cell killing in many pathological situations (Orrenius et al. 1989). Thus, Ca2+ can promote proliferation or death depending upon the cellular context.

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Author information

Authors and Affiliations

  1. Department of Cell Biology, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA

    D. J. McConkey

  2. Institute of Environmental Medicine, Division of Toxicology, Karolinska Institute, Box 210, 17177, Stockholm, Sweden

    S. Orrenius

Authors
  1. D. J. McConkey
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  2. S. Orrenius
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Editors and Affiliations

  1. Génétique Moléculaire et Biologie du Développment, CNRS-UPR 420, 19, rue Guy Môquet, BP8, 94801, Villejuif Cedex, France

    Guido Kroemer

  2. Centro Nacional de Biotecnologia CSIC Campus de Cantoblanco, Universidad Autonoma, 28049, Madrid, Spain

    Carlos Martinez-A.

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© 1995 Springer-Verlag Berlin Heidelberg

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McConkey, D.J., Orrenius, S. (1995). Calcium and Cyclosporin A in the Regulation of Apoptosis. In: Kroemer, G., Martinez-A., C. (eds) Apoptosis in Immunology. Current Topics in Microbiology and Immunology, vol 200. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79437-7_7

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  • DOI: https://doi.org/10.1007/978-3-642-79437-7_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79439-1

  • Online ISBN: 978-3-642-79437-7

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