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Death Genes in T Cells

  • Chapter
Apoptosis in Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 200))

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Abstract

Apoptosis is a general phenomenon which occurs in many organisms and in many cell types. It is characterized by chromosomal condensation, cleavage of DNA into nucleosome size fragments and subsequent cell death (Cohen et al. 1992; Ellis et al. 1991; Oppenheim 1991; Wyllie et al. 1984). Apoptosis occurs in more than 95% of thymocytes during development as a consequence of negative selection or lack of positive selection. Apoptosis is also likely to occur during peripheral tolerance in mature T cells (for review, see Cohen et al. 1992; Korsmeyer 1992). In vitro, T cell apoptosis can be initiated using antibodies for the CD3 T cell receptor complex, steroids, irradiation, and antibody specific for the Fas antigen (see below). The many cell death processes differ in their requirements and pathways. For example, the p53 gene is required for irradiation-induced T cell death but not for anti-CD3- or glucocorticoid-induced death (Lowe et al. 1993). Apoptosis by anti-CD3 and glucocorticoid requires gene transcription whereas Fas-mediated cell death does not (Cohen and Eisenberg 1992).

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Authors and Affiliations

  1. Department of Molecular and Cell Biology, Division of Immunology, University of California, Berkeley, CA, 94720-3200, USA

    J. Woronicz, B. Calnan & A. Winoto

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  1. J. Woronicz
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  2. B. Calnan
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  3. A. Winoto
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  1. Génétique Moléculaire et Biologie du Développment, CNRS-UPR 420, 19, rue Guy Môquet, BP8, 94801, Villejuif Cedex, France

    Guido Kroemer

  2. Centro Nacional de Biotecnologia CSIC Campus de Cantoblanco, Universidad Autonoma, 28049, Madrid, Spain

    Carlos Martinez-A.

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© 1995 Springer-Verlag Berlin Heidelberg

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Woronicz, J., Calnan, B., Winoto, A. (1995). Death Genes in T Cells. In: Kroemer, G., Martinez-A., C. (eds) Apoptosis in Immunology. Current Topics in Microbiology and Immunology, vol 200. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79437-7_10

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  • DOI: https://doi.org/10.1007/978-3-642-79437-7_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79439-1

  • Online ISBN: 978-3-642-79437-7

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