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Apoptosis in Immunology pp 1–14Cite as

T Cell Apoptosis Triggered via the CD3/T Cell Receptor Complex and Alternative Activation Pathways

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 200))

Abstract

Programmed cell death (apoptosis) can be triggered in immature thymocytes and (under certain conditions) in mature T lymphocytes by several distinct signals including: (1) γ-irradiation (Sellins and Cohen 1987); (2) glucocorticoids (Wyllie 1980; Nieto and López-Rivas 1989); (3) cell surface signaling via the T cell receptor (TCF)/CD3 Complex (Smith et al. 1989; Takahashi et al. 1989; McConkey et al. 1989; Shi et al. 1991; Russell et al. 1991, 1992), via the CD2 antigen (Bierer et al. 1991; Wesselborg et al. 1993a), or the Fas antigen (Owen-Schaub et al. 1992; Klas et al. 1993), or (4) by removal of essential survival and/or growth factors (Duke and Cohen 1986; Tsuda et al. 1993; Perandones et al. 1993). In most instances, programmed cell death is associated with the fragmentation of genomic DNA into oligonucleosomal fragments of approximately 180 bp in length, a hallmark of apoptosis. Even though the various death signals may all lead to the same final stage of the cell (i.e., apoptosis associated with the characteristic morphological features and DNA fragmentation), they are likely to be differentially regulated. It is conceivable that intracellular signaling pathways are differentially activated if a T cell is stimulated, e.g., by anti-CD3/TCR antibodies, glucocorticoids, or lack of interleukin-2 (IL-2) i.e., failure to perceive a signal via a functional IL-2 receptor. In addition, differences in the level of apoptosis sensitivity exist between immature thymocytes and mature peripheral T lymphocytes.

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  1. Department of Immunology, Paul-Ehrlich Institute, Paul-Ehrlich-Strasse 51-59, 63225, Langen, Germany

    D. Kabelitz, T. Pohl & K. Pechhold

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  1. D. Kabelitz
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  2. T. Pohl
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  3. K. Pechhold
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  1. Génétique Moléculaire et Biologie du Développment, CNRS-UPR 420, 19, rue Guy Môquet, BP8, 94801, Villejuif Cedex, France

    Guido Kroemer

  2. Centro Nacional de Biotecnologia CSIC Campus de Cantoblanco, Universidad Autonoma, 28049, Madrid, Spain

    Carlos Martinez-A.

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Kabelitz, D., Pohl, T., Pechhold, K. (1995). T Cell Apoptosis Triggered via the CD3/T Cell Receptor Complex and Alternative Activation Pathways. In: Kroemer, G., Martinez-A., C. (eds) Apoptosis in Immunology. Current Topics in Microbiology and Immunology, vol 200. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79437-7_1

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