Stereotactic gamma radiosurgery for malignant pineal tumours

  • Y. Mori
  • T. Kobayashi
  • Y. Kida
  • T. Tanaka
Conference paper


Seven patients with pineal tumours, including three malignant teratomas, two malignant germ cell tumours, one germinoma and one pineoblastoma were treated by radiosurgery (RS). Their mean age was 13.7 years. RS has been applied to residual pineal tumours after surgical resection, conventional irradiation, and/or chemotherapy. Those multimodality treatments were also used after RS in some cases. In five of seven cases, the tumours were stable or decreased in size with a mean follow-up time of 18.9 months after RS. Dissemination in the cerebrospinal fluid space developed in four patients, two of whom died 12 and 13 months after RS, respectively.

Key words

Pineal body Germ cell tumour Pineoblastoma Radiosurgery Gamma knife 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Borit A, Blackwood W, Mair WGP (1980) The separation of pineocytoma from pineoblastoma. Cancer 45:1408–1418.PubMedCrossRefGoogle Scholar
  2. 2.
    Gzirjak S, Vajda J, Pasztor E (1992) Management of pineal region tumours. Neurol Res 14:241–247.Google Scholar
  3. 3.
    Edwards MSB, Hudgins RJ, Wilson CB, Levin VA, Wara WM (1988) Pineal region tumors in children. J Neurosurg 68:689–697.PubMedCrossRefGoogle Scholar
  4. 4.
    Herrick MK, Rubinstein LJ (1979) The cytological differentiating potential of pineal parenchymal neoplasms (true pinealomas). A clinicopathological study of 28 tumours. Brain 102:289–320.PubMedCrossRefGoogle Scholar
  5. 5.
    Kirkove CS, Brown AP, Symon L (1991) Successful treatment of a pineal endodermal sinus tumor. J Neurosurg 74:832–836.PubMedCrossRefGoogle Scholar
  6. 6.
    Kobayashi T, Yoshida J, Noda S, Kida Y, Teraoka M, Itoh J (1990) Combination chemotherapy with CDDP and etoposide (P-E therapy) for intracranial germ-cell tumors. Shouni No Noshinkei 15:409–416.Google Scholar
  7. 7.
    Nakagawa K, Aoki Y, Akanuma A, Sakata K, Karasawa K, Terahara A, Onogi Y, Hasezawa K, Muta N, Sasaki Y (1992) Radiation therapy of intracranial germ cell tumors with radio-sensitivity assessment. Radiat Oncol 10:55–61.Google Scholar
  8. 8.
    Sebag-Montefiore DJ, Douek E, Kingston JE, Plowman PN (1992) Intracranial germ cell tumours. I. Experience with platinum-based chemotherapy and implications for curative chemoradiotherapy. Clin Oncol 4:345–350.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Y. Mori
    • 1
  • T. Kobayashi
    • 2
  • Y. Kida
    • 2
  • T. Tanaka
    • 2
  1. 1.Department of NeurosurgeryNagoya University School of MedicineShowa-ku, NagoyaJapan
  2. 2.Gamma Knife CenterKomaki City HospitalKomaki CityJapan

Personalised recommendations