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Prinzipien der Kombination von Radiotherapie und Chemotherapie

  • Chapter
Strahlentherapie

Zusammenfassung

Die Kombination von Radiotherapie und Chemotherapie hat in der Therapie von Lymphomen und soliden Tumoren große Bedeutung erlangt und wird im Rahmen kurativer Konzepte der Kinder- und Erwachsenenonkologie durchgeführt. Grundsätzlich gilt für solide Malignome des Erwachsenen, daß eine alleinige Strahlentherapie nicht nur Tumoren mikroskopischer, sondern auch makroskopischer Größe dauerhaft vernichten kann. Hingegen beherrscht — mit Ausnahme der Karzinome des Hodens — die Chemotherapie solide Tumoren nur, wenn eine mikroskopische Größe nicht überschritten ist. In einer Kombinationsbehandlung, in der beide Therapiemodalitäten am selben makroskopischen Karzinom oder Sarkom zytotoxisch wirken, ist also die Rate der durch Chemotherapie abgetöteten Tumorzellen im Vergleich zur Strahlentherapie um Größenordnungen kleiner. Dieser Aspekt sollte auch bei der Durchführung neoadjuvanter Therapiekonzepte (präoperative Kombination von Radiotherapie und Chemotherapie) berücksichtigt werden.

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Literatur

  • Aass N, Fossa SD, Aas M, Lindegaard M (1990) Renal function related to different treatment modalities for malignant germ cell tumours. Br J Cancer 62: 842–846

    Article  PubMed  CAS  Google Scholar 

  • Aristizabal SA, Manning MR, Miller RC, Leith JT, Mayer EG (1979) Combined radiation-adriamycin effects on human skin. In: Vaeth JM (ed) Combined effects of chemotherapy and radiotherapy on normal tissue tolerance. Karger, Basel (Frontiers of radiation therapy and oncology, vol 13, pp 103–112)

    Google Scholar 

  • Auberger T, Molls M, Fink U (1995) Radiochemotherapie mit kontinuierlicher Infusion oder Bolusapplikation von 5-FU bei gastrointestinalen Tumoren. Strahlenther Onkol (im Druck)

    Google Scholar 

  • Bamberg M, Schmidberger H, Hess CF (1992) G-CSF in the management of neutropenia during radiotherapy. Tumordiagn Ther 13: 125–126

    Google Scholar 

  • Bardenheuer MJ (1992) Chromosomale Aberrationen im Knochenmark der Maus nach kombinierter Applikation von Röntgenstrahlen und Cisplatin. Med. Diss., Universität Essen

    Google Scholar 

  • Bartelink H, Kallman RF, Rapaccietta D, Hart GAM (1986) Therapeutic enhancement in mice by clinically relevant dose and fractionation schedules of cis-diamminedichloroplatinum ( II) and irradiation. Radiother Oncol 6: 61–74

    Article  PubMed  CAS  Google Scholar 

  • Bartzsch O, Riepl M, Busch M et al. (1995) Einsatz von G-CSF bei multimodalen Therapiekonzepten in der Strahlentherapie. Strahlenther Onkol 171: 33 (Sonderheft I)

    Google Scholar 

  • Begg AC (1990) Cisplatin and radiation: interaction probabilities and therapeutic possibilities. Int J Radiat Oncol Biol Phys 19: 1183–1189

    Article  PubMed  CAS  Google Scholar 

  • Begg AC, Stewart FA, Dewit L, Bartelink H (1990) Interactions between cisplatin and radiation in experimental rodent tumors and normal tissues. In: Hill BT, Bellamy AS (eds) Antitumor drug-radiation interactions. CRC, Boca Raton, pp 153–190

    Google Scholar 

  • Belli JA, Piro AJ (1977) Cellular effects of combined adriamycin and X-irradiation in human tumor cells. Int J Cancer 19: 194–204

    Article  Google Scholar 

  • Berdjis CG (1971) Pathology of irradiation. Williams & Wilkins, Baltimore

    Google Scholar 

  • Billingham ME (1979) Endomyocardial changes in anthracycline-treated patients with and without irradiation. In: Vaeth JM (ed) Combined effects of chemotherapy and radiotherapy on normal tissue tolerance. Karger, Basel (Frontiers of radiation therapy and oncology, vol 13, pp 67–81)

    Google Scholar 

  • Brown JM, Koong A (1991) Therapeutic advantage of hypoxic cells in tumors: a theoretical study. J Natl Cancer Inst 83: 178–185

    Article  PubMed  CAS  Google Scholar 

  • Brown JM, Lemmon MJ (1990) Potention by the hypoxic cytotoxin SR 4233 of all killing produced by fractionated irradiation of mouse tumors. Cancer Res 50: 7745–7749

    PubMed  CAS  Google Scholar 

  • Burholt DR, Schenken LL, Kovacs CJ, Hagemann RF (1979) Response of the murine gastrointestinal epithelium to cisdichlorodiammineplatinum II: radiation combinations. Int J Radiai Oncol Biol Phys 5: 1377–1381

    CAS  Google Scholar 

  • Byfield JE, Lynch M, Kulhanian F, Chan PYM (1977) Cellular effects of combined adriamycin and X-irradiation in human tumor cells. Int J Cancer 19: 194–204

    Article  PubMed  CAS  Google Scholar 

  • Byfield JE, Calabro-Jones P, Klisak I, Kulhanian F (1982) Pharmacologic requirements for obtaining sensitization of human tumor cells in vitro to combined 5-fluorouracil or ftorafur and x-rays. Int J Radiat Oncol Biol Phys 8: 1923–1933

    Article  PubMed  CAS  Google Scholar 

  • Carde PL (1981) Effects of cis-dichlorodiammineplatinum (II) and X-rays on mammalian cell survival. Int J Radiat Oncol Biol Phys 7: 929–933

    Article  PubMed  CAS  Google Scholar 

  • Carmichael J, Hickson ID (1991) Mechanism of cellular resistance to cytotoxic drugs and x-irradiation. Int J Radiat Oncol Biol Phys 20: 197–202

    Article  PubMed  CAS  Google Scholar 

  • Casarett GW (1980) Radiation histopathology, vols I and I I. CRC, Boca Raton

    Google Scholar 

  • Catane R, Lichter A, Lee YJ et al. (1981) Small cell lung cancer: analysis of treatment factors contributing to prolonged survival. Cancer 48: 1936–1943

    Article  PubMed  CAS  Google Scholar 

  • Choi CH, Carey RW (1976) Small cell anaplastic carcinoma of the lung. Reappraisal of current management. Cancer 37: 2651–2657

    Article  PubMed  CAS  Google Scholar 

  • Concannon JP, Summers RE, King J, Tcherkow G, Cole C, Rogow E (1969) Enhancement of x-ray effects on the small intestinal epithelium of dogs by actinomycin D. Am J Roentgenol 105: 126–136

    CAS  Google Scholar 

  • D’Angio GJ (1962) Clinical and biological studies of actinomycin D and roentgen irradiation. Am J Roentgenol 87: 106–109

    Google Scholar 

  • Daugaard G, Abildgaard U (1989) Cisplatin nephrotoxicity. Cancer Chemother Pharmacol 25: 1–9

    Article  PubMed  CAS  Google Scholar 

  • DeAngelis L, Yahalom J, Thaler HT, Kher U (1992) Combined modality therapy for primary CNS lymphoma. J Clin Oncol l0: 635–643

    CAS  Google Scholar 

  • Dewitt L (1987) Combined treatment of radiation and cisdiamminedichloroplatinum (II): a review of experimental and clinical data. Int J Radiat Oncol Biol Phys 13: 403–426

    Article  Google Scholar 

  • Dold U, Hermanek P, Höffken K, Sack H (1993) Praktische Tumortherapie. Thieme, Stuttgart

    Google Scholar 

  • Donaldson SS, Moskowitz PS, Canty EL, Fajardo LF (1980) Combination radiation-adriamycin therapy: renoprival growth, functional and structural effects in the immature mouse. Int J Radiat Oncol Biol Phys 5: 851–859

    Google Scholar 

  • Douple EB, Richmond RC (1978) Platinum complexes as radiosensitizers of hypoxic mammalian cells. Br J Cancer 37: 98–102

    CAS  Google Scholar 

  • Douple EB, Richmond RC (1982) Enhancement of the potentiation of radiotherapy by platinum drugs in the mouse tumor. Int J Radiat Oncol Biol Phys 8: 501–503

    Article  PubMed  CAS  Google Scholar 

  • Douple EB, Eaton WL Jr, Tulloh ME (1979) Cis-dichlorodiammineplatinum ( II) and radiation. Int J Radiat Oncol Biol Phys 5: 1383–1385

    PubMed  CAS  Google Scholar 

  • Dritschilo A, Piro AJ, Kelman AD (1979a) The effect of cisplatinum on the repair of radiation damage in plateau phase chinese hamster (V-79) cells. Int J Radiat Oncol Biol Phys 5: 1345–1349

    PubMed  CAS  Google Scholar 

  • Dritschilo A, Piro AJ, Belli JA (1979b) Interaction between radiation and drug damage in mammalian cells. III. The effect of adriamycin and actinomycin-D on the repair of potentially lethal radiation damage. Int J Radiat Biol 35: 549–560

    CAS  Google Scholar 

  • Dunst J, Sauer R (eds) (1995) Late sequelae in oncology. Springer, Berlin Heidelberg New York Tokyo (Medical radiology series)

    Google Scholar 

  • Durand RE (1991) The influence of microenvironmental factors on the activity of radiation and drugs. Int J Radiat Oncol Biol Phys 20: 253–258

    Article  PubMed  CAS  Google Scholar 

  • Durand RE, Vanderbyl SL (1988) Response of cell subpopulations in spheroids to radiationdrug combination. NCI Monogr 6: 95–100

    PubMed  Google Scholar 

  • Eifel Pi’, Mc Clure S (1989) Severe chemotherapy-induced recall of radiation mucositis in a patient with non-Hodgkin’s lymphoma of Waldeyer’s ring. Int J Radiat Oncol Biol Phys 17: 907–909

    Article  PubMed  CAS  Google Scholar 

  • Einhorn L, Kranse M, Hornback N et al. (1976) Enhanced pulmonary toxicity with bleomycin and radiotherapy in oat cell lung cancer. Cancer 37: 2414–2416

    Article  PubMed  CAS  Google Scholar 

  • Elkind MM, Whitmore BF, Alescio T (1964) Suppression of recovery in x-irradiated mammalian cells. Science 143: 1454–1457

    Article  PubMed  CAS  Google Scholar 

  • Eltringham JR, Fajardo LF, Stewart JR, Klauber MD (1979) Investigation of cardiotoxicity in rabbits from adriamycin and fractionated cardiac irradiation: Preliminary results. In: Vaeth JM (ed) Combined effects of chemotherapy and radiotherapy on normal tissue tolerance. Karger, Basel (Frontiers of radiation therapy and oncology, vol 13, pp 21–35)

    Google Scholar 

  • Feldmann HJ, Molls M, Hoederath A, Krümpelmann S, Sack H (1992) Blood flow and steady state temperatures in deep-seated tumors and normal tissues. Int J Radiat Oncol Biol Phys 23: 1003–1008

    Article  PubMed  CAS  Google Scholar 

  • Feldmann HJ, Sievers K, Füller J, Molls M, Löhr E (1993) Evaluation of tumor blood perfusion by dynamic MRI and CT in patients undergoing thermoradiotherapy. Eur J Radiol 16: 224–229

    Article  PubMed  CAS  Google Scholar 

  • Fossa SD, Aamdal S (1992) Toxicity of combined chemotherapy and radiotherapy: clinical aspects. In: Horwich A (ed) Combined radiotherapy and chemotherapy in clinical oncology. E. Arnold, London, pp 34–39

    Google Scholar 

  • Füller J, Feldmann HT, Molls M, Sack H (1994) Untersuchungen zum Sauerstoffpartialdruck im Tumorgewebe unter Radio-and Thermoradiotherapie. Strahlenther Onkol 8: 453–460

    Google Scholar 

  • Fu KK (1985) Biological basis for the interaction of chemotherapeutical agents and radiation therapy. Cancer 55: 2123–2130

    Article  PubMed  CAS  Google Scholar 

  • Fu KK (1992) Interactions of chemotherapeutic agents and radiation. In: Meyer JL, Vaeth JM (eds) Radiotherapy/chemotherapy interactions in cancer treatment. Karger, Basel (Frontiers of radiation therapy and oncology, vol 26, pp 16–30)

    Google Scholar 

  • Fu KK, Phillips TL, Wharam MD (1976) Radiation response of artificial pulmonary metastases of the EMT6 tumor. Int J Radiat Oncol Biol Phys 1: 257–260

    Article  PubMed  CAS  Google Scholar 

  • Fu KK, Begg AB, Kane LJ, Phillips TL (1979) Interaction of radiation and adriamycin on the EMT6 tumor as a function of tumor size and assay method. Int J Radiat Oncol Biol Phys 5: 1249–1254

    PubMed  CAS  Google Scholar 

  • Fu KK, Lam KN, Rayner PA (1985) The influence of time sequence of cisplatin administration and continuous low dose rate irradiation ( CLDRI) on their combined effects on a murine squamous cell carcinoma. Int J Radiat Oncol Biol Phys 11: 2119–2124

    Article  PubMed  CAS  Google Scholar 

  • Gilladoga AC, Corazon M, Tan CC, Wollner N, Murphy ML (1975) Cardiotoxicity of adriamycin (NSC-123127) in children. Cancer Chemother Rep, part 3, vol 6: 209–214

    Google Scholar 

  • Griffin TW, Rasey JS, Bleyer WA (1977) The effect of photon irradiation on blood-brain barrier permeability to methotrexate in mice. Cancer 40: 1109–1111

    Article  PubMed  CAS  Google Scholar 

  • Hall EJ (1994) Radiobiology for the radiologist, 4th edn. Lippincott, Philadelphia

    Google Scholar 

  • Herrmann T, Schorcht J, Molls M (1995) Radiation pneumopathy - experimental and clinical data. In: Dunst J, Sauer R (eds) Late sequelae in oncology. Springer, Berlin Heidelberg New York Tokyo, pp 135–140 (Medical radiology series)

    Google Scholar 

  • Hinkelbein W, Bruggmoser G, Frommhold H, Wannenmacher M (eds) (1993) Acute and long-term side-effects of radiotherapy. Springer, Berlin Heidelberg New York Tokyo (Recent results in cancer research, vol 130 )

    Google Scholar 

  • Hoff DD von, Layard MW, Basa P, Davis HL, Hoff AL von, Rozencweig M, Muggia FM (1979) Risk factors for doxorubicin-induced congestive heart failure. Ann Intern Med 91: 710–717

    Google Scholar 

  • Iliakis G, Bryant PE (1983) Effects of the nucleoside analogues a-Ara A, b-Ara A and b-Ara C on cell growth and repair of both potentially lethal damage and DNA double-strand breaks in mammalian cells in culture. Anticancer Res 3: 143–150

    PubMed  CAS  Google Scholar 

  • Johnson RE, Breston HD, Kent C (1978) Total therapy for small cell carcinoma of the lung. Am Thorac Surg 25: 509–515

    Article  Google Scholar 

  • Kallman RF, Bedarida G, Rapacchietta D (1992) Experimental studies on schedule dependence in the treatment of cancer with combinations of chemotherapy and radiotherapy. In: Meyer JL, Vaeth JM (eds) Radiotherapy/chemotherapy interactions in cancer treatment. Karger, Basel (Frontiers of radiation therapy and oncology, vol 26, pp 31–44)

    Google Scholar 

  • Kelland LR, Steel GG (1988) Inhibition of recovery from damage induced by ionizing radiation in mammalian cells. Radiother Oncol 13: 285–299

    Article  PubMed  CAS  Google Scholar 

  • Kirkbride P, Plowman PN (1989) Platinum chemotherapy, radiotherapy and the inner ear: implications for „standard“ radiation portals. Br J Radiol 62: 457–462

    Article  PubMed  CAS  Google Scholar 

  • Kolotas C, Zamboglou N, Schnabel T et al. (1996) Effect of recombinant human granulocyte colony stimulating factor (R-MetHuG-CSF) as an adjunct to large field radiotherapy: a phase I study. Int J Radiat Oncol Biol Phys (im Druck)

    Google Scholar 

  • Korbelik M, Skov KA (1989) Inactivation of hypoxic cells by cisplatin and radiation at clinically relevant doses. Radiat Res 119: 145–156

    Article  PubMed  CAS  Google Scholar 

  • Landuyt W, Van der Scheuren E, Ang KK (1985) The effect of actinomycin D on radiation induced reactions of the lip mucosa of mice. Int J Radiat Oncol Biol Phys 11: 1503–1512

    Article  PubMed  CAS  Google Scholar 

  • Le Chevalier T, Arriagada R, de Thé H et al. (1988) Combination of chemotherapy and radiotherapy in limited small cell lung carcinoma: results of alternating schedule in 109 patients. NCI Monogr 6: 335–338

    PubMed  Google Scholar 

  • Lelieveld P, Scoles MA, Brown JM, Kallman RF (1985) The effect of treatment in fractionated schedules with the combination of X-irradiation and six cytotoxic drugs on the RIF-1 tumor and normal mouse skin. Int J Radiat Oncol Biol Phys 11: 111–121

    Article  PubMed  CAS  Google Scholar 

  • Levin VA, Edwards MS, Byrd A (1979) Quantitative observations of the acute effects of X-irradiation on brain capillary permeability. part I. Int J Radiat Oncol Biol Phys 5: 1627–1631

    PubMed  CAS  Google Scholar 

  • Lien HH, Bloomlie V, Saeter G et al. (1991) MR signal abnormalities of the brain in asymptomatic patients treated with high dose methotrexate for osteogenic sarcoma. Radiology 179: 547–549

    PubMed  CAS  Google Scholar 

  • Luk KH, Ross GY, Phillips TL, Goldstein LS (1979) The interaction of radiation and cis-diamminedichloroplatinum ( II) in intestinal crypt cells. Int J Radiat Oncol Biol Phys 5: 1417–1420

    PubMed  CAS  Google Scholar 

  • Matsushima Y, Kanzawa F, Hoshi A et al. (1985) Timeschedule dependency of the inhibiting activity of various anticancer drugs in the clonogenic assay. Cancer Chemother Pharmacol 14: 104–107

    Article  PubMed  CAS  Google Scholar 

  • McInerney DP, Bullimore J (1977) Reactivation of radiation pneumonitis by adriamycin. Br J Radiol 50: 224–227

    Article  Google Scholar 

  • Molls M, (1994) Prä-and postoperative Radiotherapie mit and ohne Chemotherapie beim Rectumcarcinom. Chirurg 65: 569–575

    PubMed  CAS  Google Scholar 

  • Molls M, Beuningen D van (1991) Radiation injury of the lung: Experimental studies, observations after radiotherapy and total body irradiation prior to bone marrow transplantation. In: Scherer E, Streffer C, Trott KR (eds) Radiopathology of organs and tissues. Springer, Berlin Heidelberg New York Tokyo, pp 369–404 (Medical radiology series)

    Google Scholar 

  • Molls M, Feldmann HJ (1991) Clinical investigations of blood flow in malignant tumors of the pelvis and the abdomen in patients undergoing thermoradiotherapy. In: Vaupel P, Jain RK (eds) Tumor blood supply and metabolic microenvironment: characterization and implications for therapy. Fischer, Stuttgart (Funktionsanalyse biologischer Systeme, Bd 20, pp 143–153 )

    Google Scholar 

  • Molls M, Fink U (1994) Perioperative radiotherapy +/- chemotherapy in rectal cancer. Ann Oncol 5: 105–113

    PubMed  Google Scholar 

  • Molls M, Streffer C (1984) The influence of G2 progression on X-ray sensivity of 2-cell mouse embryos. Int J Radiat Biol 4: 355–365

    Article  Google Scholar 

  • Molls M, Feldmann HJ, Sievers K (1992) Clinical investigations on blood perfusion in human malignancies of the pelvis and abdomen. In: Steiner R, Weisz PB, Langer R (eds) Angiogenesis: key principles–science–technology–medicine. Birkhäuser, Basel, pp 368–372

    Google Scholar 

  • Molls M, Herrmann T, Steinberg F, Feldmann HJ (1993) Radiopathology of the lung: experimental and clinical observations. In: Hinkelbein W, Bruggmoser G, Frommhold H, Wannenmacher M (eds) Acute and long-term side-effects of radiotherapy. Springer, Berlin Heidelberg (Recent results in cancer research, vol 130, pp 110–121)

    Google Scholar 

  • Molls M, Feldmann HJ, Füller J (1994) Oxygenation of locally advanced recurrent rectal cancer, soft tissue sarcoma and breast cancer. In: Vaupel P et al. (eds) Oxygen transport to tissue, vol XV. Plenum, New York, 459–463

    Chapter  Google Scholar 

  • Molls M, Feldmann HJ, Auberger T (1995) Blood flow and oxygenation status under radiotherapy: clinical investigations. In: Kogelnik HD (ed) Progress in radio-oncology, vol V. Monduzzi, Bologna, pp 123–127

    Google Scholar 

  • Moore TN, Livingston R, Heilbrun L et al. (1978) An acceptable rate of complications in combined doxorubicin-irradiation for small cell carcinoma of the lung: a Southwest Oncology Group study. Int J Radiat Oncol Biol Phys 4: 675–680

    Article  PubMed  CAS  Google Scholar 

  • O’Connell MJ et al. (1994) Improving adjuvant therapy for rectal cancer by combining protracted–infusion fluorouracil with radiation therapy after curative surgery. N Engl J Med 331: 502–507

    Article  PubMed  Google Scholar 

  • Phillips TL (1992) Effects of chemotherapy and irradiation on normal tissues. In: Meyer JL, Vaeth JM (eds) Radiotherapy/chemotherapy interactions in cancer therapy. Karger, Basel (Frontiers of radiation therapy and oncology, vol 26, pp 45–54)

    Google Scholar 

  • Praga C, Beretta G, Vigo PL et al. (1979) Adriamycin cardiotoxicity: a survey of 1273 patients. Cancer Treat Rep 63: 827–834

    PubMed  CAS  Google Scholar 

  • Rice GC, Hoy C, Schimke RT (1986) Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells. Proc Natl Acad Sci USA 83: 5978–5982

    Article  PubMed  CAS  Google Scholar 

  • Rockwell S, Sartorelli AC (1990) Mitomycin C and radiation. In: Hill BT, Bellamy AS (eds) Antitumor drug-radiation interactions. CRC, Boca Raton, pp 125–136

    Google Scholar 

  • Rotman M, Rosenthal CJ (eds) (1991) Concomitant continuous infusion chemotherapy and radiation. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Rubin P (1984) The Franz Buschke Lecture: late effects of chemotherapy and radiation therapy: a new hypothesis. Int J Radiat Oncol Biol Phys 10: 5–34

    PubMed  CAS  Google Scholar 

  • Rubin P, Casarett GW (1968) Clinical radiation pathology. Saunders, Philadelphia

    Google Scholar 

  • Schenken JL, Burholt DR, Kovacs CJ (1979) Adriamycinradiation combinations: drug induced delayed gastrointestinal radiosensitivity. Int J Radiat Oncol Biol Phys 5: 1265–1269

    PubMed  CAS  Google Scholar 

  • Scherer E, Streffer C, Trott K-R (eds) (1991) Radiopathology of organs and tissues. Springer, Berlin Heidelberg New York Tokyo (Medical radiology series)

    Google Scholar 

  • Schmoll HJ, Peters HD, Fink U (1986) Kompendium Internistische Onkologie, Teil1. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Schultz-Hector S (1991) Heart. In: Scherer E, Streffer C, Trott K-R (eds) Radiopathology of organs and tissues. Springer, Berlin Heidelberg New York Tokyo, pp 347–368 (Medical radiology series)

    Google Scholar 

  • Shipley WU, Stanley JA, Steel GG (1975) Tumor size dependency in the radiation response of the Lewis lung carcinoma. Cancer 35: 2488–2493

    CAS  Google Scholar 

  • Siemann DW (1990) Interactions between nitrosoureas and X-irradiation. In: Hill BT, Bellamy AS (eds) Antitumor drug-radiation interactions. CRC Press, Boca Raton, pp 141–151

    Google Scholar 

  • Siemann DW, Keng PC (1988) Responses of tumor cell subpopulations to single modality and combined modality therapies. NCI Monogr 6: 101–105

    PubMed  Google Scholar 

  • Stanley JA, Shipley WU, Steel GG (1977) Influence of tumor size on hypoxic fraction and therapeutic sensitivity of Lewis lung tumour. Br J Cancer 36: 105–113

    Article  PubMed  CAS  Google Scholar 

  • Steel GG, Peckham MJ (1979) Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. Int J Radiat Oncol Biol Phys 5: 85–91

    PubMed  CAS  Google Scholar 

  • Streffer C, Müller WU (1984) Radiation risk from combined exposures to ionizing radiations and chemicals. In: Lett J (ed) Adv Radiat Biol, vol11. Academic Press, London, pp 173–210

    Google Scholar 

  • Tannock JF (1992) The potential for therapeutic gain from combined modality treatment. In: Meyer JL, Vaeth JM (eds) Radiotherapy/chemotherapy: interactions in cancer treatment. Karger, Basel (Frontiers of radiation therapy and oncology, vol 26, pp 1–15 )

    Google Scholar 

  • Tannock IF, Rotin D (1988) Keynote address: mechanisms of interaction between radiation and drugs with potential for improvements in therapy. NCI Monogr 6: 77–83

    PubMed  Google Scholar 

  • Vanuytsel L, Feng Y, Landuyt W, Schueren E van der (1988) Effect of continuous infusion of bleomycin on repopulation in mouse lip mucosa during fractionated irradiation. NCI Monogr 6: 55–58

    PubMed  Google Scholar 

  • Vaupel P, Kalinowski F, Okunieff P (1989) Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49: 6449–6465

    PubMed  CAS  Google Scholar 

  • Wallner KE, Li GC (1987) Effect of cisplatin resistance on cellular radiation response. Int J Radiat Oncol Biol Phys 13: 587–591

    Article  PubMed  CAS  Google Scholar 

  • Whithers R (1992) Biologic basis of radiation therapy. In: Perez CA, Brady LW (eds) Principles and practice of radiation oncology, 2nd edn. Lippincott, Philadelphia, pp 64–96

    Google Scholar 

  • Yan R, Durand RE (1991) The response of hypoxic cells in SCCVII murine tumors to treatment with cisplatin and x-rays. Int J Radiat Oncol Biol Phys 20: 271–274

    Article  PubMed  CAS  Google Scholar 

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Molls, M. (1996). Prinzipien der Kombination von Radiotherapie und Chemotherapie. In: Scherer, E., Sack, H. (eds) Strahlentherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79432-2_7

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