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Maligne Erkrankungen bei Kindern und Jugendlichen

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Strahlentherapie

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Zusammenfassung

Leukämien und maligne Tumoren sind im Kindesalter seltene Erkrankungen. Das Kindertumorregister der Deutschen Gesellschaft für Pädiatrische Hämatologie und Onkologie an der Universität Mainz gibt die Inzidenz für die letzten 7 Jahre konstant mit 13–14 Neuerkrankungenhoo 00o Kinder unter 15 Jahren an (Haaf et al. 1993). Das Risiko eines Kindes, vor seinem 15. Geburtstag an einem Malignom zu erkranken, beträgt 0,2%. Trotz der eindrucksvollen Therapieerfolge der Kinderonkologie in den letzten beiden Jahrzehnten sind Krebserkrankungen die nach Unfällen zweithäufigste Todesursache bei Kindern jenseits des Säuglingsalters.

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Literatur

  • Arneil GC, Harris F, Emmanuel JG, Young DG, Flatman GE, Zachary RB (1974) Nephritis in two children after irradiation and chemotherapy for nephroblastoma. Lancet I: 960–963

    Google Scholar 

  • Berthold F, Brandeis WE, Lampert F (1986) Neuroblastoma: diagnostic advances and therapeutic results in 37o patients. Monogr Paediatr 18: 206–223

    Google Scholar 

  • Berthold F, Burdach S, Kremens B et al. (1990) The role of chemotherapy in the treatment of children with neuroblastoma stage IV: the GPO (German Paediatric Oncology Society) experience. Klin Pädiatr 202: 262–269

    PubMed  CAS  Google Scholar 

  • Berthold F, Trechow R, Utsch S, Zierschang J (1992) Prognostic factors in metastatic neuroblastoma. A multivariate analysis of 182 cases. Am J Pediatr Hematol Oncol 14: 207–215

    PubMed  CAS  Google Scholar 

  • Bielack SS, Beck JD, Winkler K (1995) Spätfolgen nach Krebsbehandlung im Kindesalter. Monatsschr Kinderheilkd 143: 649–657

    Google Scholar 

  • Bjorkholm E, Lundell M, Gyftodimos A (1990) Dysgerminoma: the Radiumhemmet series 1927–1984. Cancer 65: 38–44

    PubMed  CAS  Google Scholar 

  • Bloom HJG (1983) Primary intracranial germ cell tumors. Clin Oncol 2: 233–257

    Google Scholar 

  • Bloom HJG, Glees J, Bell J (1990) The treatment and long-term prognosis of children with intracranial tumors: a study of 610 cases, 1950–1981. Int J Radiat Oncol Biol Phys 18: 723–745

    PubMed  CAS  Google Scholar 

  • Brämswig JH, Wegele M, von Lengerke HJ, Müller RP, Schellong G (1989) The effect of the number of fractions of cranial irradiation on growth in children with acute lymphoblastic leukaemia. Acta Paediatr Scand 78: 296–302

    PubMed  Google Scholar 

  • Brochstein JA, Kernan NA, Groshen S et al. (1987) Allogeneic bone marrow transplantation after hyperfractionated total-body irradiation and cyclophosphamide in children with acute leukemia. N Engl J Med 317: 1618–1624

    PubMed  CAS  Google Scholar 

  • Brodeur GM, Pritchard J, Berthold F et al. (1993) Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment. J Clin Oncol 11: 1466–1477

    PubMed  CAS  Google Scholar 

  • Brouwers P, Poplack D (1990) Memory and learning sequelae in longterm survivors of acute lymphoblastic leukemia. Am J Pediatr Hematol Oncol 12: 174–181

    PubMed  CAS  Google Scholar 

  • Burdach S, Jürgens H, Peters C et al. (1993) Myeloablative radiotherapy and hematopoietic stem-cell rescue in poor-prognosis Ewing’s sarcoma. J Clin Oncol 11: 1482–1488

    PubMed  CAS  Google Scholar 

  • Cheung NKV, von Hoff D, Strandjord S, Coccia PF (1986) Detection of neuroblastoma cells in bone marrow using GD2 spedific monoclonal antibodies. J Clin Oncol 4: 363–369

    PubMed  CAS  Google Scholar 

  • Cheung NKV, Burch L, Kushner BH, Munn DH (1991) Monoclonal antibody 3 F 8 can effect durable remissions in neuroblastoma patients refractory to chemotherapy: a phase II trial. Prog Clin Biol Res 366: 395-400

    PubMed  CAS  Google Scholar 

  • Christiansen H, Schestag J, Christiansen NM, Grzeschik KH, Lampert F (1992) Clinical impact of chromosome I aberrations in neuroblastoma: a metaphase and interphase cytogenetic study. Genes Chromosom Cancer 5: 141–149

    PubMed  CAS  Google Scholar 

  • Constine LS, Donaldson SS, McDougall R, Cox RS, Link MP, Kaplan HS (1984) Thyroid dysfunction after radiotherapy in children with Hodgkin’s disease. Cancer 53: 878–883

    PubMed  CAS  Google Scholar 

  • Corn BW, Trock GJ, Goodman RL (1990) Irradiation-related ischemic heart disease. J Clin Oncol 8: 741–750

    PubMed  CAS  Google Scholar 

  • Creutzig U, Ritter J, Zimmermann M, Schellong G (1993) Does cranial irradiation reduce the risk for bone marrow relapse in acute myelogenous leukemia: unexpected results of the childhood acute myelogenous leukemia study BFM-87. J Clin Oncol 11: 279–286

    PubMed  CAS  Google Scholar 

  • D’Angio GJ, Breslow N, Beckwith JB et al. (1989) Treatment of Wilms’s tumor. Results of the third National Wilms’ Tumor Study. Cancer 64: 349

    PubMed  Google Scholar 

  • Delattre O, Zucman J, Melot T et al. (1994) The Ewing family of tumors - a subgroup of small-round-cell tumors defined by specific chimeric transcripts. N Engl J Med 331: 294–299

    PubMed  CAS  Google Scholar 

  • Donaldson SS, Jundt S, Ricour C, Sarrazin D, Lemerle J, Schweisguth O (1975) Radiation enteritis in children: a retrospective review, clinicopathologic correlation, and dietary management. Cancer 35: 1167–1178

    PubMed  CAS  Google Scholar 

  • Dopfer R, Henze G, Bender-Götze C et al. (1991) Allogeneic bone marrow transplantation for childhood acute lymphoblastic leukemia in second remission after intensive primary and relapse therapy according to the BFM- and CoALL-Protocols: results of the German Cooperative Study. Blood 78: 2780–2784

    PubMed  CAS  Google Scholar 

  • Duffner PK, Cohen ME (1992) Changes in the approach to central nervous system tumors in childhood. Pediatr Clin North Am 39: 859–877

    PubMed  CAS  Google Scholar 

  • Duffner PK, Horowitz ME, Krischer JP et al. (1993) Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors. N Engl J Med 328: 1725–1731

    PubMed  CAS  Google Scholar 

  • Dunst J, Sauer R, Burgers JMV et al. (1991) Radiation therapy as local treatment in Ewing’s sarcoma. Results of the Cooperation Ewing Sarcoma Studies CESS 81 and 86. Cancer 67: 2818–2825

    PubMed  CAS  Google Scholar 

  • Eng C, Li FP, Abramson DH et al. (1993) Mortality from second tumors among long-term survivors of retino-blastoma. J Natl Cancer Inst 85: 1121

    PubMed  CAS  Google Scholar 

  • Evans AE, Jenkin RDT, Sposto R et al. (1990) The results of a prospective randomised trial of radiation therapy with and without CCNU, vincristine and prednisolone. J Neurosurg 72: 572–582

    PubMed  CAS  Google Scholar 

  • Ewing J (1921) Diffuse endothelioma of bone. Proc NY Pathol Soc 21: 17–20

    Google Scholar 

  • Farwell JR, Dohrmann GJ, Flannery JT (1984) Medulloblastoma in childhood: an epidemiologic study. J Neurosurg 61: 657–664

    PubMed  CAS  Google Scholar 

  • Favara BE (1991) Langerhans cell histiocytosis. Pathobiology and pathogenetis. Semin Oncol 18: 3–7

    PubMed  CAS  Google Scholar 

  • Favrot M, Floret D, Michon J et al. (1989) A phase-II study of adoptive immunotherapy with continuous infusion of interleukin-2 in children with advanced neuroblastoma. A report on 11 cases. Cancer Treat Rev 16: 129–142

    PubMed  Google Scholar 

  • Finch SC (1984) Leukemia and lymphoma in abonic bomb survivors. In: Boice JD, Franmeni JF (eds) Radiation carcinogenesis: epidemiology and biological significance. Raven, New York, pp 37–44

    Google Scholar 

  • Finklestein JZ, Krailo MD, Lenarsky C et al. (1992) 13-cisRetinoic Acid (NCS 122758) in the treatment of children with metastatic neuroblastoma unresponsive to conventional chemotherapy: report from the Childrens Cancer Study Group. Med Pediatr Oncol 20: 307–311

    PubMed  CAS  Google Scholar 

  • Freeman JE, Johnston PGB, Voke JM (1973) Somnolence after prophylactic cranial irradiation in children with acute lymphoblastic leukemia. BMJ 4: 523–526

    PubMed  CAS  Google Scholar 

  • Gessler M, Poustka A, Cavenee W, Neve RL, Orkin SH, Bruns GAP (1990) Homozygous deletion in Wilms’ tumour of a zinc-finger gene identified by chromosome jumping. Nature 343: 774-778

    PubMed  CAS  Google Scholar 

  • Glauser TA, Packer R (1991) Cognitive deficits in long-term survivors of childhood brain tumors. Childs Nery Syst 7: 2–12

    CAS  Google Scholar 

  • Göbel U, Bamberg M, Calaminus G et al. (1993a) Verbesserte Prognose intracranialer Keimzelltumoren durch intensivierte Therapie: Ergebnisse des Therapieprotokolls MAKEI 89. Klin Pädiatr 205: 217–224

    Google Scholar 

  • Göbel U, Calaminus G, Teske C et al. (1993b) BEP/VIP bei Kindern und Jugendlichen mit malignen nichttestikulären Keimzelltumoren. Klin Pädiatr 205: 231–240

    Google Scholar 

  • Gonzales D, Breur K (1983) Clinical data from irradiated growing long bones in children. Int J Radiat Oncol Biol Phys 9: 841–846

    Google Scholar 

  • Green AA, Hustu HO, Palmer R, Pinkel D (1976) Total-body sequential irradiation and combination chemotherapy for children with disseminated neuroblastoma. Cancer 38: 2250–2257

    PubMed  CAS  Google Scholar 

  • Green DM, D’Angio GJ, Beckwith JB, Breslow NE, Finkle-stein JZ, Kelalis P, Thomas PRM (1993) Wilms’ tumor (nephroblastoma, renal embryoma). In: Pizzo PA, Poplack DG (eds) Principles and practice of pediatric oncology. Lippincott, Philadelphia, pp 713–737

    Google Scholar 

  • Gutjahr P (1993) Sekundärmalignome nach Krebserkrankungen bei Kindern. Dtsch Arztebl 90: 1593–1604

    Google Scholar 

  • Gutjahr P, Schwenger M, Spaar HJ et al. (1990) Bedeutung der präoperativen Chemotherapie und der Radiotherapie bei 373 Kindern mit Wilms-Tumor. Dtsch Med Wochenschr 115: 248

    PubMed  CAS  Google Scholar 

  • Haaf HG, Kaatsch P, Michaelis J (1993) Jahresbericht des Deutschen Kinderkrebsregisters, Mainz

    Google Scholar 

  • Halperin EC, Cox EB (1986) Radiation therapy in the management of neuroblastoma. The Duke University Medical Center Experience 1967–1984. Int J Radiat Oncol Biol Phys 12: 1829

    PubMed  CAS  Google Scholar 

  • Halperin EC, Kun LE, Constine LS, Tarbell NJ (1989) Pediatric radiation oncology: late effects of cancer treatment. Raven, New York, pp 344–386

    Google Scholar 

  • Hansen MF, Konfos A, Gallie BL et al. (1985) Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition. Proc Natl Acad Sci USA 82: 6216–6220

    PubMed  CAS  Google Scholar 

  • Hauffa BP, Liebers E, Bornfeld N, Sauerwein W, Havers W (1995) Wachstum und Entwicklung von Kindern und Jugendlichen mit Retinoblastom nach operativer Therapie, Strahlentherapie und Chemotherapie. Monatsschr Kinderheilkd 143: 1091–1098

    Google Scholar 

  • Havers W, Stollmann B, Bachmann HJ, Bamberg M, Stambolid C (1980) Bestrahlungsbedingte Nierenerkrankung nach Behandlung von Malignomen im Kindesalter. Onkologie 3: 58–62

    PubMed  CAS  Google Scholar 

  • Havers W, Alberti W, Messmer EP, Rath B, Höpping W (1986) Retinoblastoma. In: Riehm H (ed) Malignant neoplasias in childhood and adolescence. Monogr Paediatr 18: 342–358

    Google Scholar 

  • Hawkins MM, Droper GJ, Kingston JE (1987) Incidence of second primary tumors among childhood cancer survivors. Br J Cancer 56: 339–347

    PubMed  CAS  Google Scholar 

  • Henze G, Langermann HJ, Brämswig J et al. (1981) Ergebnisse der Studie BFM 76/79 zur Behandlung der akuten lymphoblastischen Leukämie bei Kindern und Jugendlichen. Klin Pädiatr 193: 145–157

    PubMed  CAS  Google Scholar 

  • Henze G, Fengler R, Hartmann R (1994) Chemotherapy for relapsed childhood acute lymphoblastic leukemia: results of the BFM Study Group. Haematol Blood Transfus 36: 374–379

    Google Scholar 

  • Hoppe-Hirsch E, Renier D, Lellouch-Tubiana A, Sainte-Rose C, Piere-Kahn A, Hirsch JF (1990) Medulloblastoma in childhood: progressive intellectual deterioration. Childs Nerv Syst 6: 60–65

    PubMed  CAS  Google Scholar 

  • Höpping W, Havers W, Passarge E (1990) Retinoblastom. In: Bachmann KD, Ewerbeck H, Kleihauer E et al. (Hrsg) Pädiatrie in Praxis und Klinik. Fischer und Thieme, Stuttgart, S 755–770

    Google Scholar 

  • Hudson MM, Greenwald C, Ghompson E et al. (1993) Efficacy and toxicity of multiagent chemotherapy and low-dose involved-field radiotherapy in children and adolescents with Hodgkin’s disease. J Clin Oncol 11: l00–108

    Google Scholar 

  • Hurwitz CA, Mounce KG, Grier HE (1995) Treatment of patients with acute myelogenous leukemia: review of clinical trials of the past decade. J Pediatr Hematol Onco117: 185–197

    Google Scholar 

  • Ingold JA, Reed GB, Kaplan HS, Bagshaw MA (1963) Radiation hepatitis. Am J Roentgenol 93: 200–208

    Google Scholar 

  • Jacobson HM, Marcus RB, Thar TL, Million RR, Graham-Pole JR, Thalberg JL (1983) Pediatric neuroblastoma: postoperative radiation therapy using less than 2000 rad. Int J Radiat Oncol Biol Phys 9: 501–505

    PubMed  CAS  Google Scholar 

  • Jaffe N, Filler RM, Farber S, Graggis DG, Vawter FF, Tefft M, Murray JE (1973) Rhabdomyosarcoma in children-improved outlook with a multidisciplinary approach. Am J Surg 125: 482–487

    PubMed  CAS  Google Scholar 

  • Jaffe N, Graggis D, Salian S, Cassacy JR (1976) Improved outlook for Ewing’s sarcoma with combination chemotherapy (Vincristin, Actinomycin D, and Cyclophosphamide) and radiation therapy. Cancer 38: 1925–1930

    PubMed  CAS  Google Scholar 

  • Jennings MT, Gehman R, Hochberg F (1985) Intracranial germ-cell tumors: natural history and pathogenesis. J Neurosurg 63: 155–167

    PubMed  CAS  Google Scholar 

  • Jürgens H, Exner U, Gadner H et al. (1988a) Multidisciplinary treatment of primary Ewing’s sarcoma od bone. Cancer 61: 23–32

    Google Scholar 

  • Jürgens H, Bier V, Harms D et al. (1988b) Malignant peripheral neuroectodermal tumors. A retrospective analysis of 42 patients. Cancer 61: 349-357

    Google Scholar 

  • Kaatsch P, Michaelis J (1995) Zweitmalignome nach malignen Erkrankungen im Kindesalter. Klin Pädiatr 207: 158–163

    PubMed  CAS  Google Scholar 

  • Kingston JE, Hungerford JL, Plowman PN (1987) Chemotherapy in metastatic retinoblastoma. Ophthal Paediat Gen 8: 69

    CAS  Google Scholar 

  • Klingebiel T, Berthold F, Treuner J et al. (1991) Metaiodobenzylguanidine (mIBG) in treatment of 47 patients with neuroblastoma: results of the german neuroblastoma trial. Med Pediatr Oncol 19: 84–88

    PubMed  CAS  Google Scholar 

  • Koscielniak E, Jürgens H, Winkler K et al. (1992) Treatment of soft tissue sarcoma in childhood and adolescence. Cancer 7o: 2557-2567

    Google Scholar 

  • Koscielniak E, Herbst M, Niethammer D, Treuner J (1994) Verbesserung durch einen frühen and risikoadaptierten Einsatz der Radiotherapie bei primär nicht resektablem Rhabdomyosarkomen: Ergebnisse der CWS 81 and 86 Studien. Klin Pädiatr 206: 269–276

    PubMed  CAS  Google Scholar 

  • Kremens B, Sadony W, Goepel M, Hellinger A, Havers W (1991) Management of nephroblastoma with intracardiac extension: three case reports and review of the literature. Pediatr Hematol Oncol 8: 335-345

    PubMed  CAS  Google Scholar 

  • Kremens B, Klingebiel T, Hermann F et al. (1994) High-dose consolidation with local radiation and bone marrow rescue in patients with advanced neuroblastoma. Med Pediatr Oncol 23: 470–475

    PubMed  CAS  Google Scholar 

  • Kühl J, Beck J, Bode U et al. (1995) Delayed radiation therapy (RT) after postoperative chemotherapy (PCH) in children less than 3 years of age with medulloblastoma. Results of the trial HIT-SKK 87, and preliminary results of the pilot trial HIT-SKK 92. Med Pediatr Oncol 25: 250

    Google Scholar 

  • Ladenstein R, Hartmann 0, Pinkerton R (1993) The role of megatherapy with autologous bone marrow rescue in solid tumors of childhood. Ann Oncol 4: 45–58

    PubMed  Google Scholar 

  • Leiper AD, Grant GB, Chessels JM (1983) The effect of testicular irradiation on Leydig cell function in prepubertal boys with acute lymphoblastic leukemia. Arch Dis Child 58: 906–910

    PubMed  CAS  Google Scholar 

  • Lewin K, Mills RR (1973) Human radiation hepatitis: a morphologic study with emphasis on the late changes. Arch Pathol 96: 21–26

    PubMed  CAS  Google Scholar 

  • Ludwig R, Weirich A, Pötter R et al. (1992) Präoperative Chemotherapie des Nephroblastoms. Vorläufige Ergebnisse der Therapiestudie SIOP-9/GPO. Klin Pädiatr 204: 204–213

    PubMed  CAS  Google Scholar 

  • Luxton RW, Kunkler PB (1964) Radiation nephritis. Acta Radiol 2: 169–178

    CAS  Google Scholar 

  • Mahour GH, Soule EH, Mills SD, Lynn HB (1976) Rhabdomyosarcoma in infants and children: a clinicophatologic study of 75 cases. J Pediatr Surg 2: 402–409

    Google Scholar 

  • Marcove RC, Mik¨¦ V, Hajek JV, Levin AG, Hutter RVP (1970) Osteogenic sarcoma under the age of twenty-one. A review of 145 operative cases. J Bone Joint Surg Am 52: 411–423

    PubMed  CAS  Google Scholar 

  • Molls M, Stuschke M (1991) Radiotherapy in childhood: normal tissue injuries and carcinogenesis. In: Scherer E, Streffer C, Trott KR (eds) Radiopathology of organs and tissues. Springer, Berlin Heidelberg New York Tokyo, pp 461–477 (Medical radiology series)

    Google Scholar 

  • Nesbit ME, Krivit W (1975) Histiocytosis. In: Bloom HJG, Lemerle J, Neidhardt MK, Voûte PA (eds) Cancer in children. Springer, Berlin Heidelberg New York, pp 193–199

    Google Scholar 

  • Oberlin O, Leverger G, Pacquement H et al. (1992) Low-dose radiation therapy and reduced chemotherapy in childhood Hodgkin’s disease: the experience of the French Society of Pediatric Oncology. J Clin Oncol 10: 1602–1608

    PubMed  CAS  Google Scholar 

  • Ortin TTS, Shostak CA, Donaldson SS (1990) Gonadal status and reproductive function following treatment for Hodgkin’s disease in childhood: the Stanford experience. Int J Radiat Oncol Biol Phys 19: 873–880

    PubMed  CAS  Google Scholar 

  • Packer RJ, Sutton LN, Goldwein JW et al. (1991) Improved survival with the use of adjuvant chemotherapy in the treatment of medulloblastoma. J Neurosurg 74: 433–440

    PubMed  CAS  Google Scholar 

  • Philip T, Zucker JM, Bernard JL et al. (1991) Improved survival at 2 and 5 years in the LMCE1 unselected group of 72 children with stage IV neuroblastoma older than 1 year of age at diagnosis: is cure possible in a small subgroup? J Clin Oncol 9: 1037–1044

    PubMed  CAS  Google Scholar 

  • Phillips TL, Fu KK (1978) The interaction of drug and radiation effects on normal tissues. Int J Radiat Oncol Biol Phys 4: 59–64

    PubMed  CAS  Google Scholar 

  • Phillips TL, Margolis L (1972) Radiation pathology and the clinical response of lung and esophagus. In: Vaeth JM (ed) Frontiers of therapy and oncology. Baltimore University Park Press, pp 254–273

    Google Scholar 

  • Plowman PN (1983) The effects of conventionally fractionated, exthuded portal radiotherapy on the human peripheral blood count. Int J Radiat Oncol Biol Phys 9: 829–839

    PubMed  CAS  Google Scholar 

  • Price RA, Jamieson PA (1975) The central nervous system in childhood leukemia. II. Subacute leukoencephalopathy. Cancer 35: 306–318

    PubMed  CAS  Google Scholar 

  • Raney RB, Hays DM, Lawrence W, Soule EH, Tefft M, Donaldson MH (1978) Paratesticular rhabdomyosarcoma in childhood. Cancer 42: 729–736

    PubMed  Google Scholar 

  • Rappaport R, Brauner R (1989) Growth and endocrine disorders secondary to cranial irradiation. Pediatr Res 25: 561–567

    PubMed  CAS  Google Scholar 

  • Reiter A, Schrappe M, Ludwig WD et al. (1994a) Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86. Blood 84: 3122–3133

    CAS  Google Scholar 

  • Reiter A, Schrappe M, Yasisan E et al. (1994b) Therapiestudie NHL-BFM 90 zur Behandlung maligner Non-HodgkinLymphome bei Kindern and Jugendlichen. Eine Zwischenanalyse der Therapiegruppe B-NHL/B-ALL. Klin Pädiatr 206: 242–252

    CAS  Google Scholar 

  • Reiter A, Tiemann M, Ludwig WD et al. (1994c) Therapiestudie NHL-BFM 90 zur Behandlung maligner Non-HodgkinLymphome bei Kindern and Jugendlichen. Klin Pädiatr 206: 222–233

    CAS  Google Scholar 

  • Riehm H, Gadner H, Henze G et al. (1990) Results and significance of six randomized trials in four consecutive ALL-BFM studies. Haematol Blood Transfus 33: 439–450

    PubMed  CAS  Google Scholar 

  • Riseborough EJ, Grabias SL, Burton RI, Jaffe N (1976) Skeletal alterations following irradiation for Wilms’ tumor, with particular reference to scoliosis and kyphosis. J Bone Joint Surg Am 58: 526–536

    PubMed  CAS  Google Scholar 

  • Rosen G, Murphy ML, Huvos AG, Gutierrez M, Marcove RC (1976) Chemotherapy, en bloc resection, and prosthetic bone replacement in the treatment of osteogenic sarcoma. Cancer 37: 1–11

    PubMed  CAS  Google Scholar 

  • Rosen G, Kosloff C, Lane J, Murphy ML (1981) Ewing’s sarcoma: ten year experience with adjuvant chemotherapy. Cancer 47: 2204–2213

    PubMed  CAS  Google Scholar 

  • Rubin P, Casarett GW (1969) Clinical radiation pathology, vol I & II. Saunders, Philadelphia

    Google Scholar 

  • Rubin P, Shapiro DL, Finkelstein JN, Ponney DP (1980) The early release of surfactant following lung irradiation of alveolar type II cells. Int J Radiat Oncol Biol Phys 6: 75–77

    PubMed  CAS  Google Scholar 

  • Scarantino C, Rubin P, Constine L (1984) The paradoxes in patterns and mechanisms of bone marrow regeneration after irradiation. I. Different volumes and doses. Radiother Onco1 2: 215–225

    CAS  Google Scholar 

  • Schellong G, Lietzke S, Strauch S, Kuhne B, Schneider B (1986) Bedeutung sonographischer, computertomographischer und klinischer Befunde für die Erkennung eines Abdominalbefalls beim Morbus Hodgkin im Kindesalter - Eine retrospektive statistische Analyse bei 145 Patienten der Therapiestudie DAL-HD-82. Klin Pädiatr 198: 147–154

    PubMed  CAS  Google Scholar 

  • Schellong G, Hörnig-Franz I, Rath B et al. (1994) Reduzierung der Strahlendosen auf zo-3o Gy im Rahmen einer kombinierten Chemo-/Radiotherapie beim Morbus Hodgkin im Kindesalter - Ein Berich der kooperativen Therapiestudie DAL-HD-87. Klin Pädiatr 206: 253–262

    PubMed  CAS  Google Scholar 

  • Schmidt D, Harms D (1983) Histologie und Prognose des Nephroblastoms unter Berücksichtigung der Sondervarianten. Klin Pädiatr 195: 214–221

    PubMed  CAS  Google Scholar 

  • Seeger RC, Brodeur GM, Sather H, Dalton A, Siegel SE, Wong KY, Hammond D (1985) Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N Engl J Med 313: 1111–1116

    PubMed  CAS  Google Scholar 

  • Shank B (1994) Radiotherapeutic principles of bone marrow transplantation. In: Forman S, Blume KG, Thomas ED (eds) Bone marrow transplantation. Blackwell, Boston, pp 96–113

    Google Scholar 

  • Silber JH, Radcliffe J, Peckham W et al. (1992) Whole brain irradiation and decline in intelligence: the influence of dose and age on IQ score. J Clin Oncol 1o: 1390–1396

    Google Scholar 

  • Stiller CA, Bunch KJ (1992) Brain and spinal tumours in children aged under two years: incidence and survival in Britain, 1971–1985. Br J Cancer 66: 50–53

    Google Scholar 

  • Stillmann RJ, Schingfeld JS, Schiff I (1981) Ovarian failure in long-term survivors of childhood malignancy. Am J Obstet Gynecol 139: 62–66

    Google Scholar 

  • Sutow WW, Sullivan MR, Ried HL, Taylor HG, Griffith KM (1970) Prognosis in childhood rhabdomyosarcoma. Cancer 25: 1384–1390

    PubMed  CAS  Google Scholar 

  • Tait DM, Thornton-Jones H, Bloom HJG, Lemerle J, Morris-Jones P (1990) Adjuvant chemotherapy for medulloblastoma: the first multi-centre control trial of the International Society of Paediatric Oncology (SIOP I). Eur J Cancer 26: 464–469

    PubMed  CAS  Google Scholar 

  • Tarbell N, Guinan E, Niemeyer C, Nauch P, Sallan S, Weinstein H (1988) Late onset of renal dysfunction in survivors of bone marrow transplantation. Int J Radiat Oncol Biol Phys 15: 99–104

    PubMed  CAS  Google Scholar 

  • Tefft M, Mitus A, Das L, Vowter GF, Filler RM (1970) Irradiation of the liver in children: review of experience in the acute and chronic phases, and in the intact normal and partially resected. Am J Roentgenol 108: 365–385

    CAS  Google Scholar 

  • Thachil JV, Jewett MAS, Rider WD (1981) The effects of cancer and cancer therapy on male fertility. J Urol 126: 141–145

    PubMed  CAS  Google Scholar 

  • Treuner J, Kaatsch P, Anger Y et al. (1986) Ergebnisse bei der Behandlung von Rhabdomyosarkomen bei Kindern. Ein Bericht der Cooperativen Weichteilsarkomstudie (CWS-81). Klin Pädiatr 198: 208–217

    PubMed  CAS  Google Scholar 

  • Tucker MA, Meadows AT, Boice JD (1987) Leukemia after therapy with alkylating agents for childhood cancer. J Natl Cancer Inst 78: 459–464

    PubMed  CAS  Google Scholar 

  • White L (1991) Chemotherapy in retinoblastoma: current status and future directions. Am J Pediatr Hematol Oncol 13: 189

    PubMed  CAS  Google Scholar 

  • Williams JM, Davis KS (1986) Central nervous system prophylactic treatment for childhood leukemia: neuropsychological outcome studies. Cancer Treat Rev 13: 113–127

    PubMed  CAS  Google Scholar 

  • Winkler K, Bieling P, Bielack S et al. (1991) Local control and survival from the Cooperative Osteosarcoma Study Group studies of the German Society of Pediatric Oncology and the Vienna Bone Tumor Registry. Clin Orthopaed 270: 79–86

    Google Scholar 

  • Woodard HQ, Coley BL (1947) The correlation of tissue dose and clinical response in irradiation of bone tumors and of normal bone. Am J Roentgenol 57: 464–471

    CAS  Google Scholar 

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Authors
  1. B. Kremens
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  2. W. Havers
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Editors and Affiliations

  1. Strahlenklinik, Universitätsklinikum Essen, Hufelandstraße 55, 45122, Essen, Deutschland

    Eberhard Scherer  & Horst Sack  & 

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© 1996 Springer-Verlag Berlin Heidelberg

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Kremens, B., Havers, W. (1996). Maligne Erkrankungen bei Kindern und Jugendlichen. In: Scherer, E., Sack, H. (eds) Strahlentherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79432-2_41

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  • DOI: https://doi.org/10.1007/978-3-642-79432-2_41

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79433-9

  • Online ISBN: 978-3-642-79432-2

  • eBook Packages: Springer Book Archive

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