Kolon, Rektum, Analkanal

  • U. Schulz


Kolorektale Karzinome waren 1992 in Deutschland mit 25,5 Toten auf 100 000 Einwohner die zweithäufigste Krebstodesursache (Statistisches Jahrbuch 1993). Die höchsten Inzidenzen finden sich in den sozioökonomisch höchstentwickelten Ländern mit Ausnahme Japans (z. B. 35,8 auf l00 000 in Connecticut/USA), die niedrigsten in den Entwicklungsländern (z. B. 1,9 auf l00 000 im Senegal). In den USA ist von 1950 bis 1980 die Häufigkeit des Kolonkarzinoms um 30% angestiegen, die des Rektumkarzinoms dagegen gleichgeblieben. Bei Männern zeigte sich insgesamt ein stärkerer Anstieg.


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  1. Abuchaibe O, Calvo FA, Azinovic I et al. (1993) Intraoperative radiotherapy in locally advanced recurrent colorectal cancer. Int J Radiat Oncol Biol Phys 26: 859–867PubMedCrossRefGoogle Scholar
  2. AJCC 1992: Manual for staging of cancer. Lippincott, PhiladelphiaGoogle Scholar
  3. Alabaster 0 (1992) Colorectal cancer: epidemiology, risks, and prevention. In: Ahlgren JD, Macdonald JS (eds) Gastrointestinal Oncology. Lippincott, Philadelphia, pp 243–259Google Scholar
  4. American College of Surgeons, Commission on Cancer (1979) Long-term patient care evaluation study for carcinoma of the rectum. American College of Surgeons, ChicagoGoogle Scholar
  5. Astler VB, Coller FA (1954) The prognostic significance of direct extension of carcinoma of the colon and rectum. Ann Surg 139: 846–852PubMedCrossRefGoogle Scholar
  6. Balslev I, Pedersen M, Teglbjaerg PS et al. (1986) Postoperative radiotherapy in DUKES B and C carcinoma of the rectum and rectosigmoid: a randomized multicenter study. Cancer 58: 22–28PubMedCrossRefGoogle Scholar
  7. Beart RW Jr, Martin JK Jr, Gunderson LL (1986) Management of recurrent rectal cancer. Mayo Clin Proc 61: 448–450PubMedGoogle Scholar
  8. Borgelt B, Gelber R, Kramer S et al. (198o) The palliation of brain metastases: final results of the first two studies by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 6: 1–9Google Scholar
  9. Boulis-Wassif S, Gérard A, Loygue J et al. (1984) Final results of a randomized trial on the treatment of rectal cancer with preoperative radiotherapy alone or in combination with 5-fluorouracil, followed by radical surgery. Cancer 53: 1811–1818PubMedCrossRefGoogle Scholar
  10. Broders AC (1925) The grading of carcinoma. Minn Med 8: 726–730Google Scholar
  11. Brodsky JT, Richard GK, Cohen AM et al. (1992) Variables correlated with the risk of lymph node metastasis in early rectal cancer. Cancer 69: 322–326PubMedCrossRefGoogle Scholar
  12. Cantril ST, Green JP, Schall GL et al. (1983) Primary radiation therapy in the treatment of anal carcinoma. Int J Radiat Oncol Biol Phys 9: 1271–1278PubMedCrossRefGoogle Scholar
  13. Cedermark B, Johansson H, Rutqvist LE, Wilking N (1995) The Stockholm I trial of preoperative short term radiotherapy in operable rectal carcinoma. Cancer 75: 2269–2275PubMedCrossRefGoogle Scholar
  14. Cohen AM (1987) Intraoperative radiation therapy for colorectal cancer. Probl Gen Surg 4: 76–82Google Scholar
  15. Cohen AM, Enker WE, Minsky BD (1990) Proctectomy and coloanal reconstruction for rectal cancer. Dis Colon Rectum 33: 4o - 43Google Scholar
  16. Cohen AM, Minsky BD, Schilsky RL (1993) Colon cancer. In: DeVita VT Jr, Hellman S, Rosenberg SA (eds) Cancer: Principles and practice of oncology. Lippincott, Philadelphia, pp 929–975Google Scholar
  17. Colacchio TA, Coughlin C, Taylor J et al. (199o) Intraoperative radiation therapy and hyperthermia. Morbidity and mortality from this combined treatment modality for unresectable intra-abdominal carcinomas. Arch Surg 125: 370–375Google Scholar
  18. Cram RE, Pearlman NW, Jochimsen PR (1977) Surgical management of complications of the radiation-injured gut. Am J Surg 133: 551–553PubMedCrossRefGoogle Scholar
  19. Cummings B, Keane T, Thomas G et al. (1984) Results and toxicity of the treatment of anal canal carcinoma by radiation therapy. Cancer 54: 2062–2068PubMedCrossRefGoogle Scholar
  20. Cummings B, Keane TJ, Harwood AR et al. (1985) Radiation treatment of the regional lymph nodes in carcinomas of the anal canal. Int J Radiat Oncol Biol Phys 11: 108–109Google Scholar
  21. Cutler SJ, Young JL Jr (1975) Third National Cancer Survey: incidence Data. Natl Cancer Inst Monogr 41. Washington, US Govt. Printing OfficeGoogle Scholar
  22. Cutuli B, Fenton J, Labib A et al. (1988) Anal margin carcinoma: 21 cases treated at the Institut Curie by exclusive conservative radiotherapy. Radiother Oncol 1–6Google Scholar
  23. Davis NC, Evans EB, Cohen JB et al. (1987) Colorectal cancer: a large unselected Australian series. Aust NZJ Surg 57: 153–159CrossRefGoogle Scholar
  24. Dillard BM, Spratt JS Jr, Ackerman LV et al. (1963) Epidermoid cancer of the anal margin and canal. Arch Surg 63: 772–777Google Scholar
  25. Doggett SW, Green JP, Cantril ST (1988) Efficacy of radiation therapy alone for limited squamous cell carcinoma of the anal canal. Int J Radiat Oncol Biol Phys 15: 1069–1072PubMedCrossRefGoogle Scholar
  26. Douglass HO, Moertel CG, Mayer RJ et al. (1986) Survival after postoperative combination treatment of rectal cancer. N Engl J Med 315: 1294–1295PubMedCrossRefGoogle Scholar
  27. DuBois JB (1992) Intraoperative therapy in the treatment of gastrointestinal cancer. In: Ahlgren JD, Mcdonald JS (eds) Gastrointestinal oncology. Lippincott, Philadelphia, pp 607–614Google Scholar
  28. Dukes CE (1938) The classification of cancer of the rectum. J Pathol Bacteriol 35: 322–332Google Scholar
  29. Duncan W (1985) Adjuvant radiotherapy in rectal cancer. The MRC trials. Br J Surg 72: S59–62PubMedCrossRefGoogle Scholar
  30. Eble MJ, Gademann G, Wannenmacher M (1993) Zur Wertigkeit der Radiotherapie bei Lebermetastasen. Strahlenther Onkol 169: 459–468PubMedGoogle Scholar
  31. Eble MJ, Kallinowski F, Wannenmacher M, Herfarth C (1994) Intraoperative Radiotherapie des lokal ausgedehnten und rezidivierten Rektumkarzinoms. Chirurg 65: 585–592PubMedGoogle Scholar
  32. Eisenberg B, DeCosse JJ, Harford F et al. (1982) Carcinoma of the colon and rectum: the natural history reviewed in 1704 patients. Cancer 49: 1131–1134PubMedCrossRefGoogle Scholar
  33. Emami B, Lyman J, Brown A et al. (1991) Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 21: 109–122PubMedGoogle Scholar
  34. Enker WE, Heilwell M, Janov AJ et al. (1986) Improved survival in epidermoid carcinoma of the anus in association with preoperative multidisciplinary therapy. Arch Surg 121: 1386–1390PubMedCrossRefGoogle Scholar
  35. Eschwege F, Lasser P, Chavey A et al. (1985) Squamous cell carcinoma of the anal canal: treatment by external beam irradiation. Radiother Oncol 3: 145–150PubMedCrossRefGoogle Scholar
  36. Feldmann HJ, Sack H (1993) Strahlentherapie in Kombination mit regionaler Hyperthermie bei lokal fortgeschrittenen Beckentumoren. Minimal Invasive Medizin–Med Tech 4: 9–15Google Scholar
  37. Fisher B, Wolmark N, Rockette HE et al. (1987) Adjuvant chemotherapy or postoperative radiation for rectal cancer: five-year results of NSABP Rot. In: Salmon SE (ed) Adjuvant therapy of cancer. Grune Stratton, New York, pp 547–554Google Scholar
  38. Fisher B, Wolmark N, Rockette H et al. (1988) Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: results from NSABP protocol Rot. J Natl Cancer Inst 80: 21–29PubMedCrossRefGoogle Scholar
  39. Frost DB, Richards PC, Montague ED et al. (1984) Epidermoid cancer of the anorectum. Cancer 53: 1285–1293PubMedCrossRefGoogle Scholar
  40. Gastrointestinal Tumor Study Group (1984) Adjuvant therapy of colon cancer: results of a prospectively randomized trial. N Engl J Med 31o: 737–743Google Scholar
  41. Gastrointestinal Tumor Study Group (1985) Prolongation of disease-free interval in surgically treated rectal carcinoma. N Engl J Med 312: 1465–1472CrossRefGoogle Scholar
  42. Gastrointestinal Tumor Study Group (1986) Survival after postoperative combination treatment of rectal cancer. N Engl J Med 315: 1294–1295CrossRefGoogle Scholar
  43. Gastrointestinal Tumor Study Group (1992) Radiation therapy and 5-FU with or without semustine for the treatment of patients with surgical adjuvant adenocarcinoma of the rectum. J Clin Oncol Io: 549–557Google Scholar
  44. Gelber RD, Larson M, Borgelt B, Kramer S (1981) Equivalence of radiation schedules for the palliative treatment of brain metastases in patients with favourable prognosis. Cancer 48: 1749–1753PubMedCrossRefGoogle Scholar
  45. Gérard A, Buyse M, Nordlinger B et al. (1988) Preoperative radiotherapy as adjuvant treatment in rectal cancer. Final results of a randomized study of the european organization for research and treatment of cancer. Ann Surg 208: 606–614Google Scholar
  46. Gilbert HA, Kagan AR, Nussbaum H et al. (1977) Evaluation of radiation for bone metastases: pain relief and quality of life. AJR 129: 1095–1096PubMedGoogle Scholar
  47. GITSG: s. Gastrointestinal Tumor Study GroupGoogle Scholar
  48. Goldman S, Auer G, Erhardt K et al. (1987) Prognostic significance of clinical stage, histologic grade, and nuclear DNA content in squamous cell carcinoma of the anus. Dis Colon Rectum 30: 444–448PubMedCrossRefGoogle Scholar
  49. Grabenbauer GG, Schneider IH, Gall FP et al. (1993) Epidermoid carcinoma of the anal canal: treatment by combined radiation and chemotherapy. Radiother Oncol 27: 59–62PubMedCrossRefGoogle Scholar
  50. Greenall M, Magill G, Quan S et al. (1986) Recurrent epidermoid cancer of the anus. Cancer 57: 1437–1441PubMedCrossRefGoogle Scholar
  51. Gunderson LL (1976) Combined irradiation and surgery for rectal and sigmoid carcinoma. Curr Probl Cancer 5: 40–53CrossRefGoogle Scholar
  52. Gunderson LL, Sosin H (1974) Areas of failure found at reoperation (second or symptomatic look) following „curative surgery“ for adenocarcinoma of the rectum: clinico-pathologic correlation and implications for adjuvant therapy. Cancer 34: 1278PubMedCrossRefGoogle Scholar
  53. Gunderson LL, Dosoretz DE, Hedberg DE et al. (1983) Low-dose preoperative irradiation, surgery, and elective postoperative radiation therapy for resectable rectum and rectosigmoid carcinoma. Cancer 52: 446–451PubMedCrossRefGoogle Scholar
  54. Hardcastle JD, Bussey HJR (1968) Results of surgical treatment of squamous cell carcinoma of the anal canal and anal margin seen at St. Mark’s Hospital, 1928–1966. Proc R Soc Med 61: 629PubMedGoogle Scholar
  55. Harter KW, Ahlgren JD (1992) Cancer of the anal canal and anal margin. In: Ahlgren JD, Macdonald JS (eds) Gastrointestinal oncology. Lippincott, Philadelphia, pp 437–439Google Scholar
  56. Heald RJ, Ryall RD (1986) Recurrence and survival after total mesorectal excision for rectal cancer. Lancet 1: 1479–1482PubMedCrossRefGoogle Scholar
  57. Higgins GA, Humphrey EW, Dwight RW et al. (1986) Preoperative radiation and surgery for cancer of the rectum: Veterans Administration Surgery Oncology Group, Trial II. Cancer 58: 352–359Google Scholar
  58. Hildebrandt U, Klein T, Feifel G et al. (1990) Endosonography of pararectal lymph nodes–in vitro and in vivo evaluation. Dis Colon Rectum 33: 863–868PubMedCrossRefGoogle Scholar
  59. John MJ, Flam M, Lovalvo L et al. (1987) Feasibility of nonsurgical management of anal canal carcinoma. Int J Radiat Oncol Biol Phys 13: 299–303PubMedCrossRefGoogle Scholar
  60. Koslowski L, Neugebauer W (1984) Chirurgie der Strahlenfolgen am Magen-Darm-Trakt. In: Lemperle G, Koslowski L (Hrsg) Chirurgie der Strahlenfolgen. Urban Schwarzenberg, MünchenGoogle Scholar
  61. Krook JE, Moertel CG, Gunderson LL et al. (1991) Effective surgical adjuvant therapy for high-risk rectal carcinoma. N Engl J Med 324: 709–715PubMedCrossRefGoogle Scholar
  62. Marks J, Mohiuddin M, Kakinic J (1991) New hope and promise for sphincter preservation in the management of cancer of the rectum. Semin Onco118: 388–398Google Scholar
  63. Martinez A, Schray MF (1987) Template and other extended techniques for pelvic and perineal implants. American Society for Therapeutic Radiology and Oncology Annual Meeting, BostonGoogle Scholar
  64. McGready DR, Ota DM, Rich TA et al. (1989) Prospective phase I trial of conservative management of lower rectal lesions. Arch Surg 124: 67–70CrossRefGoogle Scholar
  65. McDermott FT, Hughes ESR, Pihl E et al. (1981) Prognosis in relation to symptom duration in colon cancer. Br J Surg 13: 846–849CrossRefGoogle Scholar
  66. McDermott FT, Hughes ESR, Pihl E et al. (1985) Local recurrence after potentially curative resection for rectal cancer in a series of 1008 patients. Br J Surg 72: 34–37PubMedCrossRefGoogle Scholar
  67. Meerwaldt JH (1984) Post-irradiation diarrhea. A study of its mechanism after pelvic irradiation. Diss MD, University of RotterdamGoogle Scholar
  68. Mendenhall WM, Million RR, Bland KI et al. (1985) Preoperative radiation therapy for clinically resectable adenocarcinoma of the rectum. Ann Surg 202: 215–222PubMedCrossRefGoogle Scholar
  69. Mendiondo DA, Wong CC, Welch JP et al. (1976) Postoperative radiotherapy in carcinoma of the rectum and distal sigmoid colon. Radiology 119: 673–676PubMedGoogle Scholar
  70. Michaelson RA, Magill GB, Quan SHQ et al. (1983) Preoperative chemotherapy and radiation therapy in the management of anal epidermoid carcinoma. Cancer 51: 390–395PubMedCrossRefGoogle Scholar
  71. Minsky BD, Rich TA, Recht AR et al. (1989) Selection criteria for local excison with or without radiation therapy for rectal cancer. Cancer 63: 1421–1429PubMedCrossRefGoogle Scholar
  72. Minsky BD, Cohen AM, Enker WE et al. (1991a) Radiation therapy for unresectable rectal cancer. Int J Radiat Oncol Biol Phys 21: 1283–1289PubMedCrossRefGoogle Scholar
  73. Minsky BD, Cohen AM, Kemeny N et al. (1991b) Phase I trial of postoperative 5-FU, radiation therapy, and high dose leucovorin for resectable rectal cancer. Int J Radiat Oncol Biol Phys 22: 139–145CrossRefGoogle Scholar
  74. Mohiuddin M (1990) Consensus in cancer management: rectal cancer. Pennsylvania Oncologic Society Symposium, Stroudsberg/PAGoogle Scholar
  75. Mohiuddin M, Marks G (1987) High dose preoperative radiation and sphincter preservation in the treatment of rectal cancer. Int J Radiat Oncol Biol Phys 13: 839–842PubMedCrossRefGoogle Scholar
  76. Mohiuddin M, Derdel J, Marks G et al. (1985) Results of adiuvant radiation therapy in cancer of the rectum: Thomas Jefferson University Hospital experience. Cancer 55: 350–353Google Scholar
  77. Morgenstern L, Thompson R, Friedman NB (1977) The modern enigma of radiation enteropathy: sequelae and solutions. Am J Surg 134: 166–172PubMedCrossRefGoogle Scholar
  78. Myerson RJ, Walz BJ, Kodner IJ et al. (1989) Endocavitary radiation therapy for rectal cancer: results with and without external beam. Endocurie Hypertherm Oncol 5: 195–200Google Scholar
  79. Nieves PM, Hamana N, Varnagy R et al. (1980) Cancer del ano y del canal anal. Centre Medical 19: 101–107Google Scholar
  80. Nigro ND, Seydel HG, Constine B et al. (1983) Combined preoperative radiation and chemotherapy for squamous cell carcinoma of the anal canal. Cancer 51: 1826–1829PubMedCrossRefGoogle Scholar
  81. NIH Consensus Development Conference (199oa) Adjuvant therapy for patients with colon and rectum cancer. NCI, Office of Medical Applications of Research of the National Institute of HealthGoogle Scholar
  82. NIH Consensus Development Conference (199ob) Consensus statement. JAMA 264: 1444–1450Google Scholar
  83. Otmezguine Y, Grimard L, Calitchi E et al. (1989) A new combined approach in the conservative management of rectal cancer. Int J Radiat Oncol Biol Phys 17: 539–545PubMedCrossRefGoogle Scholar
  84. Overgaard M, Bertelsen K, Dalmark M et al. (1993) A randomised feasibility study evaluating the effect of radiotherapy alone or in combination with 5-fluorouracil in the treatment of locally recurrent or inoperable colorectal carcinoma. Acta Oncologica 32: 547–553PubMedCrossRefGoogle Scholar
  85. Pahlman L, Glimelius B (1990) Pre-or postoperative radiotherapy in rectal and rectosigmoid carcinoma: report from a randomized multicenter trial. Ann Surg 211: 187–195PubMedCrossRefGoogle Scholar
  86. Papillon 1 (1984) New prospects in the conservative treatment of rectal cancer. Dis Colon Rectum 27: 695–700CrossRefGoogle Scholar
  87. Papillon J (1990) Present status of radiation therapy in the conservative management of rectal cancer. Radiother Oncol 17: 275–283PubMedCrossRefGoogle Scholar
  88. Papillon J, Montbarbon JF (1987) Epidermoid carcinoma of the anal canal: a series of 276 cases. Dis Colon Rectum 3o: 324–333CrossRefGoogle Scholar
  89. Papillon J, Montbarbon JG, Gerard HP et al. (1989) Interstitial curietherapy in the conservative treatment of anal and rectal cancers. Int J Radiat Oncol Biol Phys 17: 1161–1169PubMedCrossRefGoogle Scholar
  90. Paradis P, Douglass HO Jr, Holyoke ED (1975) The clinical implications of a staging system for carcinoma of the anus. Surg Gynecol Obstet 141: 411–416PubMedGoogle Scholar
  91. Pelton JJ, Lanciano RM, Hoffman JP et al. (1993) The influence of surgical margins on advanced cancer treated with intraoperative radiation therapy ( IORT) and surgical resection. J Surg Oncol 53: 30–35Google Scholar
  92. Peters RK, Mack TM (1983) Patterns of anal carcinoma by gender and marital status in Los Angeles County. Br J Cancer 48: 629–636PubMedCrossRefGoogle Scholar
  93. Phillips RKS, Hittinger R, Blesovsky L et al. (1984) Local recurrence following curative surgery for large bowel cancer. Br J Surg 71: 17–20PubMedCrossRefGoogle Scholar
  94. Pichelmaier H, Hossfeld DK, Sauer R (1994) Adjuvante Therapie beim Kolon-und Rektumkarzinom. Dtsch Ärztebl 91: A 2246-A 2249Google Scholar
  95. Pihl E, Hughes ESR, McDermott FT et al. (1980) Carcinoma of the colon: cancer-specific long-term survival. Ann Surg 192: 114–117PubMedCrossRefGoogle Scholar
  96. Pilipshen SJ, Heilweil M, Quan SHQ et al. (1984) Patterns of pelvic recurrence following definitive resections of rectal cancer. Cancer 53: 1354–1362PubMedCrossRefGoogle Scholar
  97. Puthawala AA, Syed AMN, Fleming PA et al. (1982) Re-irradiation with interstitial implant for recurrent pelvic malignancies. Cancer 5o: 2810–2814CrossRefGoogle Scholar
  98. Reed WP, Garb JL, Park WC et al. (1988) Long-term results and complications of preoperative radiation in the treatment of rectal cancer. Surgery 1o3: 161–167Google Scholar
  99. Rich T, Gunderson LL, Lew R et al. (1983) Patterns of recurrence of rectal cancer after potentially curative surgery. Cancer 52: 1317–1329PubMedCrossRefGoogle Scholar
  100. Rich TA, Weiss DA, Mies C et al. (1985) Sphincter preservation in patients with low rectal cancer treated with radiotherapy with or without local excision or fulguration. Radiology 156: 527–531PubMedGoogle Scholar
  101. Riethmüller G, Schneider-Gädicke E, Schlimok G et al. (1994) Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes’C colorectal carcinoma. Lancet 343: 1177–1183PubMedCrossRefGoogle Scholar
  102. Rostock RA, Fishman EK, Zinreich ES et al. (1985) Computed tomography in radiation treatment planning of hepatic metastases. J Comput Assist Tomogr 9: 755–759PubMedCrossRefGoogle Scholar
  103. Rostock RA, Zajac AJ, Gallagher MJ et al. (1992) Radiation therapy in the treatment of colorectal cancer. In: Ahlgren JD, McDonald JS (eds) Gastrointestinal oncology. Lippincott, Philadelphia, pp 360–361Google Scholar
  104. Roswit B, Higgins GA Jr, Keehn R (1975) Preoperative irradiation for carcinoma of the rectum and rectosigmoid colon: report of a national veterans administration randomized study. Cancer 35: 1597–1602PubMedCrossRefGoogle Scholar
  105. Sack H, Thesen N (1993) Bestrahlungsplanung. Thieme, StuttgartGoogle Scholar
  106. Salmon RJ, Zafrani B, Habib A et al. (1986) Prognosis of cloacogenic and squamous cancers of the anal canal. Dis Colon Rectum 29: 336–340PubMedCrossRefGoogle Scholar
  107. Sargeant IR, Tobias JS, Blackman G et al. (1993) Radiation enhancement of laser palliation for advanced rectal and rectosigmoid cancer: a pilot study. Gut 34: 958–962PubMedCrossRefGoogle Scholar
  108. Sause WT, Martz KL, Noyes D et al. (1990) RTOG-81–15/ ECOG-83–23 Evaluation of preoperative radiation therapy in operable rectal carcinoma. Int J Radiat Oncol Biol Phys 19 [Supp11]: 179Google Scholar
  109. Schlienger M, Touboul E, Mauban S et al. (1991) Résultats du traitement de 286 cas de cancers épidermoides du canal anal dont 236 par irradiation à visée conservative. Lyon Chir 87: 61–69Google Scholar
  110. Schraut WH, Wang CH, Dawson PJ et al. (1983) Depth of invasion, location, and size of cancer of the anus dictate operative treatment. Cancer 51: 1291–1296PubMedCrossRefGoogle Scholar
  111. Shank B, Enker WE, Santana J et al. (1987) Local control with preoperative radiotherapy alone versus „sandwich“ radiotherapy for rectal carcinoma. Int J Radiat Oncol Biol Phys 13: 111–115PubMedGoogle Scholar
  112. Shaw EG, Gunderson LL, Martin JK et al. (1990) Peripheral nerve and ureteral tolerance to intraoperative radiation therapy: clinical and dose-response analysis. Radiother Oncol 18: 247–255PubMedCrossRefGoogle Scholar
  113. Shepherd NA, Scholefield JH, Love SB et al. (1990) Prognostic factors in anal squamous carcinoma: a multivariate analysis of clinical, pathological, and flow cytometric parameters in 235 cases. Histopathology 16: 545–555PubMedCrossRefGoogle Scholar
  114. Sigmon WR, Randall ME, Olds WW et al. (1994) Increased chronic bowel complications with split-course pelvic irradiation. Int J Radiat Oncol Biol Phys 28: 349–353PubMedCrossRefGoogle Scholar
  115. Sischy B, Doggett RL, Krall JM et al. (1989) Definitive irradiation and chemotherapy for radiosensitation in management of anal carcinoma: interim report on Radiation Therapy Oncology Group study no. 8314. Journ Natl Cancer Inst 81: 850–856CrossRefGoogle Scholar
  116. Statistisches Bundesamt (1993) Statistisches Jahrbuch für die Bundesrepublik Deutschland. Statistisches Bundesamt, Wiesbaden, S 468–469Google Scholar
  117. Stockholm Rectal Cancer Study Group (1990) Preoperative short-term radiation therapy in operable rectal cancer: a randomized trial. Cancer 66: 49–55CrossRefGoogle Scholar
  118. Tepper JE, Cohen AM, Wood WC et al. (1987) Postoperative radiation therapy of rectal cancer. Int J Radiat Oncol Biol Phys 13: 5–10PubMedCrossRefGoogle Scholar
  119. Thoni AF, Greiner R, Peyer T et al. (1992) Sphinktererhaltende Strahlentherapie des Analkarzinoms. Schweiz Med Wochenschr 122: 1689–1693PubMedGoogle Scholar
  120. Tobin RL, Mohiuddin M, Marks G (1991) Preoperative irradiation for cancer of the rectum with extrarectal fixation. Int J Radiat Oncol Biol Phys 21: 1127–1132PubMedCrossRefGoogle Scholar
  121. Tong D, Gillick L, Hendrickson FR (1982) The palliation of symptomatic osseous metastases: final results of the study of the Radiation Therapy Oncology Group. Cancer 50: 893–899PubMedCrossRefGoogle Scholar
  122. UICC (1992) TNM-Klassifikation maligner Tumoren, 4. Aufl, 2. Rev. Springer, Berlin Heidelberg New York TokyoGoogle Scholar
  123. Umpleby HC, Bristol JB, Rainey JB, Williamson RC (1984) Survival of 727 patients with single carcinoma of the large bowel. Dis Colon Rectum 27: 803–807PubMedCrossRefGoogle Scholar
  124. Willet CG, Tepper JE, Donelly S et al. (1989) Patterns of failure following local excision and postoperative therapy for invasive rectal adenocarcinoma. J Clin Oncol 7: 1003–1008Google Scholar
  125. Willett CG, Shellito PC, Tepper JE et al. (1991) Intraoperative electron beam radiation therapy for recurrent locally advanced rectal or rectosigmoid carcinoma. Cancer 67: 1504–1508PubMedCrossRefGoogle Scholar
  126. Wilson SM, Beahrs OH (1976) A curative treatment of carcinoma of the sigmoid, rectosigmoid and rectum. Ann Surg 183: 556–565PubMedCrossRefGoogle Scholar
  127. Zhou XG, Yu BM, Shen YX (1983) Surgical treatment and late results in 1226 cases of colorectal cancer. Dis Colon Rectum 26: 250–256PubMedCrossRefGoogle Scholar

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