Skip to main content
SpringerLink
Log in

Pankreas, Gallenwege, Leber

  • Chapter
Strahlentherapie

  • 161 Accesses

Zusammenfassung

Die Karzinome des Pankreas bilden etwa 2–6% aller Karzinome. 1991 betrug die Inzidenz in den Vereinigten Staaten ca. 29 000 Neuerkrankungen (Rich et al. 1993). Nach statistischen Erhebungen sind 1990 in den USA ca. 25 000 Todesfälle an Pankreaskarzinom zu verzeichnen, d. h. es steht dort an 5. Stelle der Mortalitätsrate maligner Erkrankungen. Zwischen 1950 und 1985 stieg die Todesrate des Pankreaskarzinoms erheblich an. Derzeit liegt die jährliche Mortalitätsrate bei 10,2 Toten auf l00 000 Männer und 7,2 Toten auf 100 000 Frauen (American Cancer Society 1990).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 149.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Abe M, Shibamoto Y, Nishimura Y (1993) Intraoperative radiotherapy for pancreatic cancer in Japan: Multi-institutional and Kyoto University experiences. In: Schildberg FW, Willich N, Krämling H-J (eds) Intraoperative radiation therapy. Verlag Die blaue Eule, Essen, pp 278–281

    Google Scholar 

  • Alden ME, Mohiuddin M (1994) The impact of radiation dose in combined external beam and intraluminal IR-192 brachytherapy for bile duct cancer. Int J Radiat Oncol Biol Phys 28: 945–951

    Article  PubMed  CAS  Google Scholar 

  • Brambs H-J, Fritz P (1994) Intraductal HDR brachytherapy of the bile duct carcinoma: Freiburg and Heidelberg experience. In: Bruggmoser G, Mould RF (eds) Freiburg Oncology Series Monogr 1. Brachytherapy Review. AlbertLudwigs-Universität, Freiburg, pp 121–126

    Google Scholar 

  • Brambs H-J, Freund U, Bruggmoser G, Laaff H, Kluger UW, Roth R, Wannenmacher M (1993) Strahlenempfindlichkeit des gesunden Gallengangs bei High-dose-rate-Afterloadingbestrahlung mit Iridium 192. Strahlenther Onkol 169: 721–728

    PubMed  CAS  Google Scholar 

  • Calvo FA, Aristu JJ, Azinovic I (1992a) Intraoperative and external radiotherapy in resected gastric cancer: updated report of a phase II trial. Int J Radiat Oncol Biol Phys 24: 729–736

    Article  PubMed  CAS  Google Scholar 

  • Calvo FA, Santos M, Pardo F et al (1992b) Gastric cancer. In: Calvo FA, Santos M, Brady LW (eds) Intraoperative radiotherapy. Clinical experiences and results. Springer, Berlin Heidelberg New York Tokyo, pp 51–56

    Google Scholar 

  • Calvo FA, Azinovic I, Zornoza G et al (1992c) Pancreatic cancer. In: Calvo FA, Santos M, Brady LW (eds) Intraoperative radiotherapy. Clinical experiences and results. Springer, Berlin Heidelberg New York Tokyo, pp 57–64

    Google Scholar 

  • Coia L, Hoffman J, Scher R et al (1994) Preoperative chemoradiation for adenocarcinoma of the pancreas and duodenum. Int J Radiat Oncol Biol Phys 30: 161–167

    PubMed  CAS  Google Scholar 

  • Cumhur T, Ozmen MN, Akhan 0, Ölcer T, Cekirge S, Ozdemir E (1995) Malignant biliary obstruction: treatment with self-expandable metallic stents. Eur Radiol 5: 6–12

    Article  Google Scholar 

  • Dobelbower RR Jr, Wagner SM, Fadell RJ, Howard JM, Didio L (1990) Pancreatic cancer. In: Dobelbower RR Jr (ed) Gastrointestinal cancer. Radiation therapy. Springer, Berlin Heidelberg New York Tokyo, pp 115–147

    Google Scholar 

  • Dobelbower RR Jr, Konski AA, Merrick HW et al (1991) Intra-operative electron beam radiation therapy ( IOEBRT) for carcinoma of the exocrine pancreas. Int J Radiat Oncol Biol Phys 20: 113–119

    Google Scholar 

  • Earle JD, Foley JF, Wienand HS et al (1993) Evaluation of external-beam radiation therapy plus 5-fluorouracil (5-FU) versus external-beam radiation therapy plus hycanthone ( HYC) in confined, unresectable pancreatic cancer. Int J Radiat Oncol Biol Phys 28: 207–211

    Google Scholar 

  • Eble MJ, Gademann G, Wannenmacher M (1993) Zur Wertigkeit der Radiotherapie bei Lebermetastasen. Strahlenther Onkol 169: 459–468

    PubMed  CAS  Google Scholar 

  • Flentje M, Weirich A, Pötter R, Ludwig R (1994) Hepatotoxicity in irradiated nephroblastoma patients during postoperative treatment according to SIOP9/GPOH. Radiother Oncol 31: 222–228

    Article  PubMed  CAS  Google Scholar 

  • Foo ML, Gunderson LL, Nagorney DM et al (1993) Patterns of failure in grossly reserted pancreatic ductal adenocarcinoma treated with adjuvant irradiation ± 5-Fluorouracil. Int J Radiat Oncol Biol Phys 26: 483–489

    Article  PubMed  CAS  Google Scholar 

  • Fritz P, Brambs H-J, Schraube P et al (1994) Combined external beam radiotherapy and intraluminal high dose rate brachytherapy on bile duct carcinomas. Int J Radiat Oncol Biol Phys 29: 855–861

    Article  PubMed  CAS  Google Scholar 

  • Frommhold H (1992) Strahlentherapie des Pankreaskarzinoms. In: Kozuschek W, Paquet K-J (Hrsg) Pankreas–Diagnostik, Therapie. Karger, Basel, S 387–390

    Google Scholar 

  • Frommhold H, Albrecht T, Glaser K, Url M (1989) Individual field shaping in pancreatic cancer, dosimetric results. Strahlenther Onko1165: 770

    Google Scholar 

  • Garton GR, Gunderson LL, Nagorney DM et al (1993) High-dose preoperative external beam and intraoperative irradiation for locally advanced pancreatic cancer. Int J Radiat Oncol Biol Phys 27: 1153–1157

    Article  PubMed  CAS  Google Scholar 

  • Glaser K, Bodner E, Klingler A (1993) Adjuvant intraoperative radiation therapy (IORT) of pancreatic cancer during radical resection. In: Schildberg FW, Willich N, Krämling H-J (eds) Intraoperative radiation therapy. Verlag Die blaue Eule, Essen, pp 282–286

    Google Scholar 

  • Goldson AL (1978) Early experience with intraoperative radiotherapy. Int J Radiat Oncol Biol Phys 3: 244

    Google Scholar 

  • Goldson AL (1991) Intraoperative radiotherapy for pancreatic cancer - requiem or revival? Int J Radiat Oncol Biol Phys 21: 1389

    Article  PubMed  CAS  Google Scholar 

  • Gouliamos AD, Kotoulas G, Giannopoulou C, Kalovidouris A, Papavasiliou C (1991) Reversible CT findings of the liver after radiotherapy. Radiother Oncol 21: 67–68

    Article  PubMed  CAS  Google Scholar 

  • Grab J, Krämling H-J, Rübe C, Willich N, Schildberg FW (1993) IORT in the treatment of resectable pancreatic carcinoma. In: Schildberg FW, Willich N, Krämling H-J (eds) Intraoperative radiation therapy. Verlag Die blaue Eule, Essen, pp 287–290

    Google Scholar 

  • Gunderson LL (1994) Rationale for and results of intraoperative radiation therapy. Cancer 74: 537–541

    Article  PubMed  CAS  Google Scholar 

  • Gunderson LL, Willett CG (1992) Pancreas and hepatobiliary tract. In: Perez CA, Brady LW (eds) Principles and practice of radiation oncology, 2nd edn. Lippincott, Philadelphia, pp 985–999

    Google Scholar 

  • Hannesson PH, Andren-Sandberg A, Stridbeck H, Cwikiel W (1995) Treatment of malignant biliary obstruction by per-cutaneous transhepatic insertion of expandable metallic stents. Eur Radiol 5: 1–5

    Article  Google Scholar 

  • Iwasaki Y, Todoroki T, Fukao K, et al. (1988) The role of intra-operative radiation therapy in the treatment of bile duct cancer. World J Surg 12: 91

    Article  PubMed  CAS  Google Scholar 

  • Kalser MH, Ellenberg SS (1985) Pancreatic cancer: adjuvant combined radiation and chemotherapy following curative resection. Arch Surg 12o: 899

    Google Scholar 

  • Kawamura M, Kataoka M, Fujii T et al (1992) Electron beam intraoperative radiation therapy ( EBIORT) for localized pancreatic carcinoma. Int J Radiat Oncol Biol Phys 23: 751–757

    Google Scholar 

  • Kinsella TJ, Sindelar WF, Tepper JE, Tochner Z, Rich TA (1988) Intraoperative radiotherapy. In: Withers HR, Peters LJ (eds) Innovations in radiation oncology. Springer, Berlin Heidelberg New York Tokyo, pp 143–153

    Chapter  Google Scholar 

  • Köster R, Scherer E (1984) Gegenwärtiger Stand und Möglichkeiten der Strahlentherapie bei der interdisziplinären Behandlung der Malignome des Magens, des Pankreas und der Gallenwege. I. Magenkarzinom. Strahlentherapie 160: 224–235

    Google Scholar 

  • Krämling HJ, Willich N, Cramer C, Wilkowski R, Dühmke E, Schildberg FW (1994) IORT in gastric cancer. IORT ‘84, 5th International Symposium: abstract and poster. Hepatogastroenterology 41: 12

    Google Scholar 

  • Kurisu K, Hishikawa Y, Taniguchi M, Kamikonya N, Miura T, Kanno H, Okamoto E (1991) High-dose-rate intraluminal brachytherapy for bile duct carcinoma after surgery. Radiother Oncol 21: 65–66

    Article  PubMed  CAS  Google Scholar 

  • Latz D, Schraube P, Eble MJ (1993) Primäre Strahlentherapie des inoperablen oder rezidivierten Pankreaskarzinoms–Heidelberger Krankengut von 1982 bis 1992. Strahlenther Onkol 169: 387–393

    PubMed  CAS  Google Scholar 

  • Lawrence T, Dworzanin LM, Walker-Andrews SC et al (1991) Treatment of cancers involving the liver and porta hepatis with external beam irradiation and intraarterial hepatic fluorodeoxyuridine. Int J Radiat Oncol Biol Phys 20: 555–561

    Article  PubMed  CAS  Google Scholar 

  • Lawrence TS, Ten Haken RK, Kessler ML et al (1992) The use of 3-D dose volume analysis to predict radiation hepatitis. Int J Radiat Oncol Biol Phys 23: 781–788

    Article  PubMed  CAS  Google Scholar 

  • Leibel SA, Guse C, Order SE et al (1990) Accelerated fractionation radiation therapy for liver metastases: selection of an optimal patient population for the evaluation of late hepatic injury in RTOG studies. Int J Radiat Oncol Biol Phys 18: 523–528

    Article  PubMed  CAS  Google Scholar 

  • Mahe M, Romestaing P, Talon B, Ardiet J-M, Salerno N, Sentenac I, Gerard J-P (1991) Radiation therapy in extrahepatic bile duct carcinoma. Radiother Oncol 21: 121–127

    Article  PubMed  CAS  Google Scholar 

  • Meerwaldt JH (1990) Biliary cancer. In: Dobelbower RR Jr (ed) Gastrointestinal cancer. Radiation therapy. Springer, Berlin Heidelberg New York Tokyo, pp 149–166

    Google Scholar 

  • Minsky BD, Wesson MF, Armstron JG et al (1990) Combined modality therapy of extrahepatic biliary system cancer. Int J Radiat Oncol Biol Phys 18: 1157–1163

    Article  PubMed  CAS  Google Scholar 

  • Mohiuddin M, Rosato F, Barbot D et al (1992) Long-term results of combined modality treatment with I-125 implantation for carcinoma of the pancreas. Int J Radiat Oncol Biol Phys 23: 305–311

    Article  PubMed  CAS  Google Scholar 

  • Montemaggi P, Dobelbower R, Crucitti F et al (1991) Interstitial brachytherapy for pancreatic cancer: report of seven cases treated with ’~5I and a review of the literature. Int J Radiat Oncol Biol Phys 21: 451–457

    Article  PubMed  CAS  Google Scholar 

  • Nilles A, Haberstroh J, Rogaczewski B (1996) Etablierung eines Infektionsmodells am Truncus coeliacus beim Kaninchen. Forschungsförderung des Universitätsklinikums Freiburg i. Br.

    Google Scholar 

  • Nishimura A, Nakano M, Otsu H et al (1984) Intraoperative radiotherapy for advanced carcinoma of the pancreas. Cancer 54: 2375–2384

    Article  PubMed  CAS  Google Scholar 

  • Rich TA, Evans DB, Levin B (1993) Current status of IORT in the treatment of pancreatic cancer. In: Schildberg FW, Willich N, Krämling H-J (eds) Intraoperative radiation therapy. Verlag Die blaue Eule, Essen, pp 273–277

    Google Scholar 

  • Roldan GE, Gunderson LL, Nagorney DM et al (1988) External beam versus intraoperative and external beam irradiation for locally advanced pancreatic cancer. Cancer 61: 1110–1116

    Article  PubMed  CAS  Google Scholar 

  • Russell AH, Clyde C, Wasserman TH, Turner SS, Rotman M (1994) Accelerated hyperfractionated hepatic irradiation in the management of patients with liver metastases: results of the RTOG dose escalating protocol. Int J Radiat Oncol Biol Phys 27: 117–123

    Google Scholar 

  • Scherer E (1987) Pankreaskarzinome. In: Scherer E (Hrsg) Strahlentherapie, 3. Aufl. Springer, Berlin Heidelberg New York Tokyo, S 657–663

    Google Scholar 

  • Shipley WU (1983) Radiation therapy in the management of patients with adenocarcinoma of the pancreas. In: Brooks JR (ed) Surgery of the pancreas. Saunders, Philadelphia, pp 319–325

    Google Scholar 

  • Silverberg E, Lubera JA (1989) Cancer statistics, 1989. CA 39: 3–20

    Article  PubMed  CAS  Google Scholar 

  • Sindelar WF, Tepper JE, Kinsella TJ (1994) Late effects of intraoperative radiation therapy on retroperitoneal tissues, intestine, and bile duct in a large animal model. Int J Radiat Oncol Biol Phys 29: 781–788

    Article  PubMed  CAS  Google Scholar 

  • Stillwagon GB, Order SE, Guse C et al (1991) Prognostic factors in unresectable hepatocellulare cancer: Radiation Therapy Oncology Group study 83–01. Int J Radiat Oncol Biol Phys 20: 65–71

    Article  PubMed  CAS  Google Scholar 

  • Tepper JE, Noyes D, Krall JM et al (1991) Intraoperative radiation therapy of pancreatic carcinoma: a report of RTOG8505. Int J Radiat Oncol Biol Phys 21: 1145–1149

    Article  PubMed  CAS  Google Scholar 

  • Thompson WM, Trenkner S (1991) Gastrointestinal malignancies: radiologic staging and follow-up. Int J Radiat Oncol Biol Phys 21: 1367–1371

    Article  PubMed  CAS  Google Scholar 

  • Todoroki T (1993) IORT for the treatment of biliary tract cancer. In: Schildberg FW, Willich N, Krämling H-J (eds) Intraoperative radiation therapy. Verlag Die blaue Eule, Essen, pp 335–343

    Google Scholar 

  • Treurniet-Donker AG, van Mierlo MJM, van Putten WLJ (1990) Localized unresectable pancreatic cancer. Int J Radiat Oncol Biol Phys 18: 59–62

    Article  PubMed  CAS  Google Scholar 

  • UICC (1987, 1992) TNM-Klassifikation maligner Tumoren (4. Aufl. 1987; 4. Aufl., 2. Rev. 1992 ) Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • UICC (1993) TNM-Atlas. Illustrierter Leitfaden zur TNM/ pTNM-Klassifikation maligner Tumoren, 3. Aufl. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Veeze-Kuijpers B, Meerwaldt JH, Lameris JS et al (1990) The role of radiotherapy in the treatment of bile duct carcinoma. Int J Radiat Oncol Biol Phys 18: 63–67

    Article  PubMed  CAS  Google Scholar 

  • Whittington R, Bryer MP, Haller DG, Solin LJ, Rosato EF (1991) Adjuvant therapy of resected adenocarcinoma of the pancreas. Int J Radiat Oncol Biol Phys 21: 1137–1143

    Article  PubMed  CAS  Google Scholar 

  • Wood WC, Shipley WU, Gunderson LL, Cohen AM, Nardi GL (1982) Intraoperative irradiation for unresectable pancreatic carcinoma. Cancer 49: 1272–1275

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. H. Frommhold
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Strahlenklinik, Universitätsklinikum Essen, Hufelandstraße 55, 45122, Essen, Deutschland

    Eberhard Scherer  & Horst Sack  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Frommhold, H. (1996). Pankreas, Gallenwege, Leber. In: Scherer, E., Sack, H. (eds) Strahlentherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79432-2_23

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-79432-2_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79433-9

  • Online ISBN: 978-3-642-79432-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation