Skip to main content
SpringerLink
Log in

Speicheldrüsen

  • Chapter
Strahlentherapie

Zusammenfassung

Speicheldrüsentumoren machen lediglich 1% aller Neoplasien und 3–4% aller Kopf-Hals-Tumoren aus. Generell findet man benigne Formen bevorzugt in der jüngeren (im Mittel 40. Lebensjahr) und maligne Formen in der höheren Altersgruppe (im Mittel 55. Lebensjahr). Bei den reinen Karzinomen fällt der Altersgipfel in das 6. bis 7. Lebensjahrzehnt, jedoch finden sich auch im frühen Kindesalter bereits Neoplasien (3%), die zu 57% in der Parotis lokalisiert sind, im Gegensatz zu 15–25% bei Erwachsenen (Ogata et al. 1994; Seifert et al. 1984). Die Inzidenz der malignen Tumoren ist bei beiden Geschlechtern etwa gleich. Bei den benignen Tumoren weist das Adenolymphom (Warthin-Tumor) eine Bevorzugung der Männer, das pleomorphe Adenom eine Bevorzugung der Frauen auf.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 149.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Abbey LM, Schwab BH, Landau GC, Perkins ER (1984) Incidence of second primary breast cancer among patients with a first primary salivary gland tumor. Cancer 54: 1439–1442

    Article  PubMed  CAS  Google Scholar 

  • Armstrong JG, Harrison LB, Thaler HT et al. (1992) The indications for elective treatment of the neck in cancer of the major salivary glands. Cancer 69: 615–619

    Article  PubMed  CAS  Google Scholar 

  • Arndt J (1973) Indikationen und Grenzen der Strahlentherapie bösartiger Neubildungen. Fischer, Stuttgart

    Google Scholar 

  • Batsakis JG, Regezi JA, Bloch D (1979) The pathology of head and neck tumors: salivary glands, part 3. Head Neck Surg 1: 260–274

    Article  PubMed  CAS  Google Scholar 

  • Batterman JJ, Breur K, Hart G, van Peperzeel HA (1981) Observations on pulmonary metastases in patients after single doses and multiple fractions of fast neutrons and cobalt-6o-gamma rays. Europ J Cancer 5: 539–548

    Google Scholar 

  • Borthne A, Kjellevold K, Kaalhus O, Vermund H (1986) Salivary gland malignant neoplasms: treatment and prognosis. Int J Radiat Oncol Biol Phys 12: 747–754

    Article  PubMed  CAS  Google Scholar 

  • Buchholz TA, Shimotakahara G, Weymuller EA, Laramore GE, Griffin TW (1993) Neutron radiotherapy for adenoid cystic carcinoma of the head and neck. Neutron Radiother 119: 747–752

    CAS  Google Scholar 

  • Byers RM, Jesse RH, Guillamondegui OM, Luna MA (1973) Malignant tumors of the submaxillary gland. Am J Surg 126: 458–463

    Article  PubMed  CAS  Google Scholar 

  • Catterall M, Errington RD (1987) The implications of improved treatment of malignant salivary gland tumors by fast neutron radiotherapy. Int J Radiat Oncol Biol Phys 13: 1313–1318

    Article  PubMed  CAS  Google Scholar 

  • Dawson AK, Orr JA (1985) Long-term results of local excision and radiotherapy in pleomorphic adenoma of the parotid. Int J Radiat Oncol Biol Phys 11: 451–455

    Article  PubMed  CAS  Google Scholar 

  • Dimery IW, Jones LA, Verjan RP, Raymond AK, Goepfert H, Hong WK (1987) Estrogen receptors in normal salivary gland and salivary gland carcinoma. Arch Otolaryngol Head Neck Surg 113: 1082–1085

    Article  PubMed  CAS  Google Scholar 

  • Ellis ER, Million RR, Mendenhall WM, Parsons JT, Cassisi NJ (1988) The use of radiation therapy in the management of minor salivary gland tumors. Int J Radiat Oncol Biol Phys 15: 613–617

    Article  PubMed  CAS  Google Scholar 

  • Eneroth CM (1969) Incidence and prognosis of salivary gland tumors at different sites. A study of parotid submandibular and palatal tumours in 263 patients. Acta Otolaryngol 263: 174–178

    CAS  Google Scholar 

  • Eneroth CM, Hamberger CA (1974) Principles of treatment of different types of parotid tumors. Laryngoscope 84: 1732–1740

    Article  PubMed  CAS  Google Scholar 

  • Eneroth CM, Jakobsson PA, Blanck C (1966) Acinic cell carcinoma of the parotid gland. Cancer 19: 1761–1772

    Article  PubMed  CAS  Google Scholar 

  • Engenhart R, Huber P, Debus J, Höver KH, Wannenmacher M (1996) Int J Radiol Oncol Biol Phys 6 accepted

    Google Scholar 

  • Fitzpatrick PJ, Theriault C (1986) Malignant salivary gland tumors. Int J Radiol Oncol Biol Phys 12: 1743–1747

    Article  CAS  Google Scholar 

  • Flentje M, Kimmig B, Kuttig H, zum Winkel K (1988) Elektronentherapie bei malignen Parotistumoren. Strahlentherapie 164: 136–140

    CAS  Google Scholar 

  • Frazell EL (1954) Clinical aspects of tumors of the major salivary gland. Cancer 7: 637–659

    Article  PubMed  CAS  Google Scholar 

  • Garden AS, Weber RS, Ang KK, Morrison WH, Matre J, Peters LJ (1993) Postoperative radiation therapy for malignant tumors of minor salivary glands. Cancer 73: 2563–2569

    Article  Google Scholar 

  • Glanzmann C (1990) Langzeit-Resultate nach postoperativer und primärer Radiotherapie von Karzinomen der Kopfspeicheldrüsen: Bedeutung von Dosis und Zielvolumen. Strahlenther Onkol 166: 183–189

    PubMed  CAS  Google Scholar 

  • Gleave EN, Whittaker JS, Nicholson A (1979) Salivary tumors: experience over 3o years. Clin Otolaryngol 4: 247–257

    Article  PubMed  CAS  Google Scholar 

  • Goepfert H, Luna MA, Lindberg RD, White AK (1983) Malignant salivary gland tumors of the paranasal sinuses and nasal cavity. Arch Otolaryngol 109: 662–668

    Article  PubMed  CAS  Google Scholar 

  • Gray SR, Cornog JL Jr, Seo IS (1976) Onocytic neoplasms of salivary glands. A report of fifteen cases including two malignant oncocytomas. Cancer 38: 1306–1317

    Article  PubMed  CAS  Google Scholar 

  • Griffin TW (1991) Optimal treament for salivary gland tumors. Int J Radiat Oncol Biol Phys 3: 857–858

    Google Scholar 

  • Griffin TW, Pajak TF, Laramore GE, Duncan W, Richter MP, Hendrickson FR, Maor MH (1988) Neutron vs. photon irradiation of inoperable salivary gland tumors: results of an RTOG-MRC cooperative randomized study. Int J Radiat Oncol Biol Phys 15: 1085–1090

    Article  PubMed  CAS  Google Scholar 

  • Guillamondegui OM, Byers RM, Luna MA, Chiminazzo H, Jesse RH, Fletcher GH (1975) Aggressive surgery in treatment for parotid cancer: the role of adjunctive postoperative radiotherapy. AJR 1233: 49–54

    Google Scholar 

  • Harrison LB, Armstrong JG, Spiro RH, Fass DE, Strong EW (1990) Postoperative radiation therapy for major salivary gland malignancies. J Surg Oncol 45: 52–55

    Article  PubMed  CAS  Google Scholar 

  • Jackson GL, Luna MA, Byers RM (1983) Results of surgery alone and surgery combined with postoperative radiotherapy in the treatment of cancer of the parotid gland. Am J Surg 146: 497–500

    Article  PubMed  CAS  Google Scholar 

  • Jiang GL, Ang KK, Peters LJ, Wendt CD, Oswald MJ, Goepfert H (1991) Maxillary sinus carcinomas: natural history and results of postoperative radiotherapy. Radiother Oncol 21: 193–200

    Article  PubMed  CAS  Google Scholar 

  • Jiang GL, Tucker SL, Guttenberger R, Peters LF, Morrison WH, Garden AS (1994) Radiation-incuced injury to the visual pathway. Radiother Oncol 30: 17–25

    Article  PubMed  CAS  Google Scholar 

  • Johns ME, Kaplan MJ (1987) Surgical therapy of tumors of the salivary glands. In: Thawley SE, Panje WR (eds) Comprehensive management of head and neck tumors. Saunders, Philadelphia, pp 634–648

    Google Scholar 

  • Kreitner KF, Zapf S, Collo D, Kutzner J (1988) Zum Stellenwert der Strahlentherapie in der Behandlung adenoidzystischer Karzinome im Kopf-and Halsbereich. Strahlentherapie 164: 451–456

    CAS  Google Scholar 

  • Krüll A, Schwarz R, Heyer D, Timm H, Schmidt R (1995) Ergebnisse der Neutronentherapie bei rezidivierenden malignen Speicheldrüsentumoren im Kopf-Hals-Bereich. Strahlenther Onkol 171: 265–271

    PubMed  Google Scholar 

  • Krüll A, Schwarz R, Engenhart R et al. (1996) European results in neutron therapy in malignant salivary gland tumors. Bulletin in Cancer (in press)

    Google Scholar 

  • Laramore GE, Krall JM, Griffin TW et al. (1993) Neutron versus photon irradiation for unresectable salivary gland tumors: final report of an RTOG-MRC randomized clinical trial. Int J Radiat Oncol Biol Phys 27: 235–240

    PubMed  CAS  Google Scholar 

  • Leafstedt SW, Gaeta JF, Sako K, Marchetta FC, Shedd DP (1972) Adenoid cystic carcinoma of major and minor salivary glands. Am J Surg 122: 756–762

    Article  Google Scholar 

  • Mayan AGD, Mackenzie IJ, Stanley RE (1984) Recurrent pleomorphic adenomas of the parotid gland. Arch Otolaryngol 110: 167–171

    Article  Google Scholar 

  • Mark J, Ekedahl C (1987) Polyclonal chromosomal evolution in a benign mixed salivary gland tumor. Cancer Genet Cytogenet 28: 237–243

    Article  PubMed  CAS  Google Scholar 

  • Matsuba H, Simpson J, Mauney M, Thawley S (1986) Adenoid cystic salivary gland carcinoma: a clinicopathologic correlation. Head Neck Surg 8: 200

    Article  PubMed  CAS  Google Scholar 

  • Million RR, Cassisi NJ (1994a) Major salivary gland tumors. In: Million RR, Cassisi NJ (eds) Management of head and neck cancer. Lippincott, Philadelphia, pp 711–735

    Google Scholar 

  • Million RR, Cassisi NJ (1994b) Minor salivary gland tumors. In: Million RR, Cassisi NJ (eds) Management of head and neck cancer. Lippincott, Philadelphia, pp 737–750

    Google Scholar 

  • Mira JG, Wescott WB, Starcke EN, Shannon IL (1981) Some factors influencing salivary function when treating with radiotherapy. Int J Radiat Oncol Biol Phys 7: 535–541

    Article  PubMed  CAS  Google Scholar 

  • Mossman KL (1983) Quantitative radiation dose-response relationships for normal tissues in man. II. Response of the salivary glands during radiotherapy. Radiat Res 95: 392–398

    Article  PubMed  CAS  Google Scholar 

  • Mossmann KL, Chencharick JD, Scheer AC, Walker WP, Ornitz RD, Rogers CC, Henkin RI (1979) Radiation-induced changes in gustatory function comparison of effects of neutron and photon irradiation. Int J Radiat Oncol Biol Phys 5: 521–528

    Article  Google Scholar 

  • Muir C, Waterhouse J, Mack T, Powell J, Whelans S (eds) (1987) Cancer incidence in five continents, Vol 5. International Agency for Research on Cancer (IARC), Lyon

    Google Scholar 

  • Neese M, Fletcher H (1989) Tumors of the major and minor salivary glands. In: Laramore GE (ed) Radiation therapy of head and neck cancer. Springer, Berlin Heidelberg New York Tokyo, pp 181–196

    Chapter  Google Scholar 

  • Noltenius H (1987) Speicheldrüsenkarzinome. In: Noltenius H (Hrsg) Pathologie und Klinik der menschlichen Tumoren. Urban & Schwarzenberg, München, S 580–606

    Google Scholar 

  • Ogata H, Ebihara S, Mukai K (1994). Salivary gland neoplasms in children. Jpn J Clin Oncol 24: 88–93

    PubMed  CAS  Google Scholar 

  • Parsons JT, Mendenhall WM, Bova FJ, Million RR (1992) Head and neck cancer. In: Levitt SH, Khan FM, Potish RA (eds) Levitt and Tapley’s technological basis of radiation therapy: practical clinical applications, 2nd edn. Lea & Febiger, Philadelphia, pp 203–231

    Google Scholar 

  • Peters LJ, Goepfert H, Ang KK et al. (1993) Evaluation of the dose for postoperative radiation therapy of head and neck cancer: first report of prospective randomized trial. Int J Radiat Oncol Biol Phys 26: 3–11

    Article  PubMed  CAS  Google Scholar 

  • Pötter R, Naszaly A, Hemprich A, Haverkamp U, Al-Dandashi A, Höver KH, Loncar I (1990) Neutron radiotherapy in adenoidcystic carcinoma. Prelimary experience at the Münster neutron facility. Strahlenther Onkol 166: 78–85

    PubMed  Google Scholar 

  • Preston-Martin S, Thomas DC, White SC, Cohen D (1988) Prior exposure to medical and dental X-rays related to tumors of the parotid gland. J Natl Cancer Inst 80: 943–949

    Article  PubMed  CAS  Google Scholar 

  • Prior P, Waterhouse JAH (1977) Second primary cancers in patients with tumors of the salivary glands. Br J Cancer 36: 362–368

    Article  PubMed  CAS  Google Scholar 

  • Rafla S (1977) Malignant parotid tumors: natural history and treatment. Cancer 40: 136–144

    Article  PubMed  CAS  Google Scholar 

  • Rafla-Demetrious S (1970) Submaxillary gland tumors. Cancer 26: 821–826

    Article  Google Scholar 

  • Rafla S, Rafla-Demetrious S (1973) Significance and treatment of lymph node metastases of malignant mucous and salivary gland tumors. Am J Roentgenol Radium Ther Nucl Med 117: 595–604

    PubMed  CAS  Google Scholar 

  • Regine WF, Mendenhall WM, Parsons JT, Stringer SP, Cassisi NJ, Million RR (1993) Radiotherapy for adenoid cystic carcinoma of the palate. Head Neck 2: 241–244

    Article  Google Scholar 

  • Saemundsen AK, Albeck H, Hansen JPH et al. (1982) Epstein-Barr virus in nasopharyngeal and salivary gland carcinomas of Greenland eskimos. Br J Cancer 46: 721–726

    Article  PubMed  CAS  Google Scholar 

  • Sakata K, Aoki Y, Karasawa K, Nakagawa K et al. (1994) Radiation therapy for patients of malignant salivary gland tumors with positive surgical margins. Strahlenther Onkol 170: 342–346

    PubMed  CAS  Google Scholar 

  • Saroja KR, Mansell J, Hendrickson FR, Cohen L, Lennox A (1987) An update on malignant salivary gland tumors treated with neutrons at fermilab. Int J Radiat Oncol Biol Phys 13: 1319–1325

    Article  PubMed  CAS  Google Scholar 

  • Schiff PB, Harrison LB, Strong EW, Fass DE, Shah JP, Spiro R (1990) Impact of the time interval between surgery and postoperative radiation therapy on locoregional control in advanced head and neck cancer. J Surg Oncol 43: 203–208

    Article  PubMed  CAS  Google Scholar 

  • Schwab W, Clasen B, Steinhoff H-J (1987) Neue and geänderte Richtlinien zum TNM-System im Kopf-Hals-Bereich. HNO 35: 112–118

    PubMed  CAS  Google Scholar 

  • Schwarz R, Krüll A, Heyer D, Baumann M, Schmidt R, Hübener K-H (1994) Present results of neutron therapy. Acta Oncol 33: 281–287

    Article  PubMed  CAS  Google Scholar 

  • Seifert G, Miehlke A, Haubrich J, Chilla R (1984) Speicheldrüsenkrankheiten. Pathologie - Klinik - Therapie - Fazialischirurgie. Thieme, Stuttgart

    Google Scholar 

  • Shore-Freedman E, Abrahams C, Recant W, Schneider AB (1983) Neurilemomas and salivary gland tumors of the head and neck following childhood irradiation. Cancer 51: 2159–2163

    Article  PubMed  CAS  Google Scholar 

  • Spiro RH, Koss LG, Hajdu SI, Strong EW (1973) Tumors of minor salivary origin: a clinicopathologic study of 492 cases. Cancer 31: 117–129

    Article  PubMed  CAS  Google Scholar 

  • Spiro RH, Huvos G, Strong EW (1975) Cancer of the parotid gland. Am J Surg 130: 452–459

    Article  PubMed  CAS  Google Scholar 

  • Spiro RH, Huvos AG, Berk R, Strong EW (1978a) Mucoepidermoid carcinoma of salivary gland origin. Am J Surg 136: 461–468

    Article  PubMed  CAS  Google Scholar 

  • Spiro RH, Huvos AG, Strong EW (1978b) Acinic cell arcinoma of salivary origin–a clinicopathologic study of 67 cases. Cancer 41: 924–935

    Article  PubMed  CAS  Google Scholar 

  • Takeichi N, Hirose F, Yamamoto H, Ezaki H, Fujikura T (1983) Salivary gland tumors in atomic bomb survivors, Hiroshima/Japan. Cancer 52: 377–385

    Article  PubMed  CAS  Google Scholar 

  • Teshima T, Inoue T, Inoue T et al. (1993) Radiation therapy for carcinoma of the major salivary glands. Strahlenther Onkol 169: 486–491

    PubMed  CAS  Google Scholar 

  • UICC (1992) TNM-Klassifikation maligner Tumoren, 4. Aufl, 2. Rev. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Vikram B, Strong EW, Shah JP, Spiro RH (1984) Radiation therapy in adenoid-cystic carcinoma. Int J Radiat Oncol Biol Phys 10: 221–223

    Article  PubMed  CAS  Google Scholar 

  • Vrielinck LJG, Ostyn F, Van Damme B, Van den Bogaert W, Fossion E (1988) The significance of perineural spread in adenoid cystic carcinoma of the major and minor salivary glands. Int J Oral Maxillofac Surg 17: 190–193

    Article  PubMed  CAS  Google Scholar 

  • Wang CC, Goodmann M (1991) Photon irradiation of unresectable carcinomas of salivary glands. Int J Radiat Oncol Biol Phys 21: 569–576

    Article  PubMed  CAS  Google Scholar 

  • Weber RS, Palmer JM, El-Naggar A, McNeese MD, Guillamondegui OM, Byers RM (1989) Minor salivary gland tumors of the lip and buccal mucosa. Laryngoscope 99: 6–9

    Article  PubMed  CAS  Google Scholar 

  • Weber RS, Byers RM, Petit B, Wolf P, Ang K, Luna M (1990) Submandibular gland tumors: advers histologic factors and therapeutic implications. Arch Otolaryngol Head Neck Surg 116: 1055–1060

    Article  PubMed  CAS  Google Scholar 

  • Woods JE, Chong GC, Beahrs OH (1975) Experience with 1360 primary parotid tumors. Am J Surg 130: 460–462

    Article  PubMed  CAS  Google Scholar 

  • Zielke-Temme B, Wannenmacher M (1978) Adenoid-cystic carcinoma (cylindroma) in the head and neck. A clinical review of 82 cases. Acta Radiol Onco 117: 401–413

    Article  Google Scholar 

Download references

Authors
  1. R. Engenhart-Cabillic
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Wannenmacher
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Strahlenklinik, Universitätsklinikum Essen, Hufelandstraße 55, 45122, Essen, Deutschland

    Eberhard Scherer  & Horst Sack  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Engenhart-Cabillic, R., Wannenmacher, M. (1996). Speicheldrüsen. In: Scherer, E., Sack, H. (eds) Strahlentherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79432-2_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-79432-2_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79433-9

  • Online ISBN: 978-3-642-79432-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation