Abstract
Attempts to understand the nature of the CNS dysfunction in schizophrenia have to contend with two important facts: (a) there is no unitary brain lesion found in all schizophrenic patients; and (b) the brain lesions found in some schizophrenic patients are not unique or specific to schizophrenia “because other disorders that are associated with pathology in similar brain areas usually do not present as schizophrenia” (Weinberger 1987). In addition, there often appears to be a significant delay (more than a decade) between the time wher the brain lesions first occur and the first appearance of positive symptoms ot schizophrenia. Post mortem studies suggest that brain lesions occur very early in life (in many instances during foetal development) and are static, nonprogressive (Weinberger 1987).
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Asarnow, R.F., Caplan, R., Asarnow, J.R. (1995). Neurobehavioral Studies of Schizophrenic Children: A Developmental Perspective on Schizophrenic Disorders. In: Häfner, H., Gattaz, W.F. (eds) Search for the Causes of Schizophrenia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79429-2_5
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