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Search for the Causes of Schizophrenia pp 227–251Cite as

31P Magnetic Resonance Spectroscopy Study of Brain Metabolism in Schizophrenia

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Abstract

The underlying neurobiological basis of schizophrenia remains poorly understood after over 30 years of intensive research. Although progress has been made in neuroanatomical, neurochemical, neurophysiolgic, and genetic research in schizophrenia, only a few integrative models have been proposed (for reviews see Bachneff 1991; Csernansky et al. 1991; Hoffman and McGlashan 1993; Keshavan and Ganguli 1990; Wyatt et al. 1989). Anatomical research has provided evidence that the frontal and limbic systems and their interconnections are involved in schizophrenia. However, structural changes in other brain areas have been reported and, taken together, the anatomical studies do not support a localized structural abnormality in schizophrenia. Cerebral metabolic functional imaging studies, discussed below, also provide evidence for frontal lobe involvement in schizophrenia. From a pathophysiological perspective, the dopaminergic system has been implicated (Meltzer and Stahl 1976; Seeman 1987), However, extensive research in this area has not provided unequivocal support for the classical dopamine hypothesis (Carlsson 1988; Crow 1987; Henley 1991; Reynolds 1989). The argument for the involvement of dopaminergic pathways in schizophrenia comes largely from the analysis of the mechanisms of action of antipsychotic drugs. The glutamatergic neurotransmitter system also has been implicated in schizophrenia (Kim et al. 1980).

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  1. Neurophysics Laboratory, Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O’Hara Street, 15213, Pittsburgh, PA, USA

    R. McClure, M. Keshavan, N. J. Minshew, K. Panchalingam & J. W. Pettegrew

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  1. R. McClure
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  2. M. Keshavan
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  3. N. J. Minshew
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  4. K. Panchalingam
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  5. J. W. Pettegrew
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  1. Central Institute of Mental Health, P.O. Box 122120, 68072, Mannheim, Germany

    Heinz Häfner  & Wagner Farid Gattaz  & 

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McClure, R., Keshavan, M., Minshew, N.J., Panchalingam, K., Pettegrew, J.W. (1995). 31P Magnetic Resonance Spectroscopy Study of Brain Metabolism in Schizophrenia. In: Häfner, H., Gattaz, W.F. (eds) Search for the Causes of Schizophrenia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79429-2_14

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