Abstract
It is well proven that the manifestation of schizophrenia is under genetic control (Kendler and Diehl 1993). It is however less clear:
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1.
How relevant environmental factors are, and how they operate and interact with genetic factors.
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2.
If the genetic susceptibility is identical across the total population of schizophrenics (or at least across all subjects with familial schizophrenia), or if the specific genetic components vary across families.
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3.
What is transmitted in families of schizophrenics and how co-familial traits are related to genetic and genetic risk factors; are only disorders and symptoms that belong to the schizophrenic sepctrum transmitted or are neurophysiological, neuropsychological, or biochemical correlates also transmitted (independent of the occurrence of the disease)?
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Maier, W. (1995). Genetic Heterogeneity and Phenotype Variation of Schizophrenia. In: Häfner, H., Gattaz, W.F. (eds) Search for the Causes of Schizophrenia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79429-2_10
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