Genetic Heterogeneity and Phenotype Variation of Schizophrenia

  • W. Maier
Conference paper


It is well proven that the manifestation of schizophrenia is under genetic control (Kendler and Diehl 1993). It is however less clear:
  1. 1.

    How relevant environmental factors are, and how they operate and interact with genetic factors.

  2. 2.

    If the genetic susceptibility is identical across the total population of schizophrenics (or at least across all subjects with familial schizophrenia), or if the specific genetic components vary across families.

  3. 3.

    What is transmitted in families of schizophrenics and how co-familial traits are related to genetic and genetic risk factors; are only disorders and symptoms that belong to the schizophrenic sepctrum transmitted or are neurophysiological, neuropsychological, or biochemical correlates also transmitted (independent of the occurrence of the disease)?



Affective Disorder Familial Risk Unipolar Depression Multiplex Family Schizotypal Personality Disorder 
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© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • W. Maier
    • 1
  1. 1.Department of PsychiatryUniversity of MainzMainzGermany

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