Abstract
The initial treatment of choice for all thymomas, with the exception of rare cases presenting with grossly unresectable local disease or diffuse metastases, is complete tumor resection. Surgical considerations are discussed elsewhere in this volume [1]. While various investigators have suggested that histological morphology [2–5] and flow cytometric assessment [6] may have prognostic implications, the primary determinants of clinical outcome are surgicopathologic staging and the related extent of surgical resection [7–10], which then form the basis for selection of adjuvant radiation and/or chemotherapy.
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References
Wilkins EW Jr (1995) Thymoma: surgical management. In: Wood DE, Thomas CR Jr (eds), Medical Radiology. Diagnostic Imaging and Radiation Oncology — Mediastinal Tumors. Springer-Verlag, Heidelberg, pp 11–18
Marino M, Muller-Hermelink HK (1985) Thymoma and thymic carcinoma. Relation of thymoma epithelial cells to the cortical and medullary differentiation of thymus. Virchows Arch [A] Pathol Anat Histopathol 407: 119–149
Verley JM, Hollmann KH (1985) Thymoma. A comparative study of clinical stages, histologic features, and survival in 200 cases. Cancer 55: 1074–1086
Pescarmona E, Rendina EA, Venuta F, et al. (1990) Analysis of prognostic factors and clinicopathological staging of thymoma. Ann Thorac Surg 50: 534–538
Quintanilla-Martinez L, Wilkins EW Jr, Ferry JA, Harris NL (1993) Thymoma — morphologic subclassification correlates with invasiveness and immunohistologic features: a study of 122 cases. Hum Pathol 24: 958–969
Pollack A, El-Nagger AK, Cox JD, Ro JY, Sahin A, Komaki R (1992) Thymoma. The prognostic significance of flow cytometric DNA analysis. Cancer 69: 1702–1709
Nakahara K, Ohno K, Hashimoto J, et al. (1988) Thymoma: results with complete resection and adjuvant postoperative irradiation in 141 consecutive patients. J Thorac Cardiovasc Surg 95: 1041–1047
Wick MR (1990) Assessing the prognosis of thymomas. Ann Thorac Surg 50: 521–522
Maggi G, Casadio C, Cavallo A, Cianci R, Molinatti M, Ruffini E (1991) Thymoma: results of 241 operated cases. Ann Thorac Surg 51: 152–156
Wilkins EW Jr, Grillo HC, Scannell JG, Moncure AC, Mathisen DJ (1991) Role of staging in prognosis and management of thymoma. Ann Thorac Surg 51: 888–892
Bergh NP, Gatzinsky P, Larsson S, Lundin P, Ridell B (1978) Tumors of the thymus and thymic region I. Clinicopathological studies of thymomas. Ann Thorac Surg 25: 91–98
Masaoka A, Monden Y, Nakahara K, Tanioka T (1981) Follow-up study of thymomas with special reference to their clinical stages. Cancer 48: 2485–2492
Wilkins EW Jr, Castleman B (1979) Thymoma: a continuing survey at the Massachusetts General Hospital. Ann Thorac Surg 28: 252–256
Curran WJ Jr, Kornstein MJ, Brooks JJ, Turrisi AT (1988) Invasive thymoma: the role of mediastinal irradiation following complete or incomplete surgical resection. J Clin Oncol 6: 1722–1727
Yamakawa Y, Masaoka A, Hashimoto T, et al. (1991) A tentative tumor-node-metastasis classification of thymoma. Cancer 68: 1983–1987
Arakawa A, Yasunaga T, Saitoh Y, et al. (1990) Radiation therapy of invasive thymoma. Int J Radiat Oncol Biol Phys 18: 529–534
Jackson MA, Ball DL (1991) Post-operative radiotherapy in invasive thymoma. Radiother Oncol 21: 77–82
Batata MA, Martini N, Huvos AG, Aguilar RI, Beattie EJ (1974) Thymomas: clinicopathologic features, therapy, and prognosis. Cancer 34: 389–396
Nordstrom DG, Tewfik HH, Latourette HB (1979) Thymoma: therapy and prognosis as related to operative staging. Int J Radiat Oncol Biol Phys 5: 2059–2062
Appelqvist P, Kostiainen S, Franssila K, Mattila S, Grohn P (1982) Treatment and prognosis of thymoma: a review of 25 cases. J Surg Oncol 20: 265–268
Maggi G, Giaccone G, Donadio M, et al. (1986) Thymomas. A review of 169 cases, with particular reference to results of surgical treatment. Cancer 58: 765–776
Haniuda M, Morimoto M, Nishimura H, Kobayashi O, Yamanda T, Iida F (1992) Adjuvant radiotherapy after complete resection of thymoma. Ann Thorac Surg 54:311–315
Pollack A, Komaki R, Cox JD, et al. (1992) Thymoma: treatment and prognosis. Int J Radiat Oncol Biol Phys 23:1037–1043
Etienne T, Deleaval PJ, Spiliopoulos A, Megevand R (1993) Thymoma: prognostic factors. Eur J Cardiothorac Surg 7: 449–452
Urgesi A, Monetti U, Rossi G, Ricardi U, Maggi G, Sannazzari GL (1992) Aggressive treatment of intrathoracic recurrences of thymoma. Radiother Oncol 24:221–225
Urgesi A, Monetti U, Rossi G, Ricardi U, Casadio C (1990) Role of radiation therapy in locally advanced thymoma. Radiother Oncol 19:273–280
Chahinian AP, Bhardwaj S, Meyer RJ, Jaffrey IS, Kirschner PA, Holland JF (1981) Treatment of invasive or metastatic thymoma: report of eleven cases. Cancer 47: 1752–1761
Marks RD Jr, Wallace KM, Pettit HS (1978) Radiation therapy control of nine patients with malignant thymoma. Cancer 41: 117–119
Monden Y, Nakahara K, Iioka S, et al. (1985) Recurrence of thymoma: clinicopathological features, therapy, and prognosis. Ann Thorac Surg 39: 165–169
Penn CRH, Hope-Stone HF (1972) The role of radiotherapy in the management of malignant thymoma. Br J Surg 59: 533–539
Ariaratnam LS, Kainicki S, Mincer F, Botstein C (1979) The management of malignant thymoma with radiation therapy. Int J Radiat Oncol Biol Phys 5: 77–80
Arriagada R, Bretel JJ, Caillaud JM, et al. (1984) Invasive carcinoma of the thymus. A multicenter retrospective review of 56 cases. Eur J Cancer Clin Oncol 20: 69–74
Cohen DJ, Ronnigen LD, Graeber GM, et al. (1984) Management of patients with malignant thymoma. J Thorac Cardiovasc Surg 87: 301–307
Kersh CR, Eisert DR, Hazra TA (1985) Malignant thymoma: role of radiation therapy in management. Radiology 156:207–209
Krueger JB, Sagerman RH, King GA (1988) Stage III thymoma: results of postoperative radiation therapy. Radiology 168: 855–858
Emami B (1992) Mediastinum and trachea. In: Perez CA, Brady LW (eds) Principles and Practice of Radiation Oncology, 2nd edn. Lippincott, Philadelphia, pp 837–852
Uematsu M, Kondo M (1986) A proposal for treatment of invasive thymoma. Cancer 58: 1979–1984
Roach M III, Vijayakumar S (1995) The role of three- dimensional conformal radiotherapy in the treatment of mediastinal tumors. In: Wood DE, Thomas CR Jr (eds) Medical Radiology. Diagnostic Imaging and Radiation Oncology-Mediastinal tumors. Springer-Verlag, Heidelberg, pp 117–123
Loehrer PJ (1993) Thymomas. Current experience and future directions in therapy. Drugs 45: 477–487
Bonomi PD, Finkelstein D, Aisner S, Ettinger D (1993) EST 2582 phase II trial of cisplatin in metastatic or recurrent thymoma. Am J Clin Oncol 16: 342–345
Harper PG, Highley M, Rankin E, et al. (1991) Ifosfamide monotherapy demonstrates high activity in malignant thymoma. Proc Am Soc Clin Oncol 10: 300 (abstract #1049)
Goldel N, Boning L, Fredrik A, Hozel D, Hartenstein R, Wilmanns W (1989) Chemotherapy of invasive thymoma: a retrospective study of 22 cases. Cancer 63: 1493–1500
Hue E, Levine J (1986) Chemotherapy of malignant thymoma: case report and review of the literature. Cancer 57: 1101–1104
Loehrer PJ, Perez CA, Roth LM, Greco A, Livingston RB, Einhorn LH (1990) Chemotherapy for advanced thymoma: preliminary results of an intergroup study. Ann Intern Med 113: 520–524
Fornasiero A, Daniele O, Ghiotto C, et al. (1991) Chemotherapy for invasive thymoma: a 13-year experience. Cancer 68: 30–33
Macchiarini P, Chella A, Ducci F, et al. (1991) Neoadjuvant chemotherapy, surgery, and postoperative radiation therapy for invasive thymoma. Cancer 68: 706–713
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Koh, WJ., Loehrer, P.J., Thomas, C.R. (1995). Thymoma: Radiation and Chemotherapy. In: Wood, D.E., Thomas, C.R. (eds) Mediastinal Tumors. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79426-1_3
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DOI: https://doi.org/10.1007/978-3-642-79426-1_3
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