Regulation and Structure of the MAP Kinases ERK1 and ERK2

  • M. H. Cobb
  • J. E. Hepler
  • E. Zhen
  • D. Ebert
  • M. Cheng
  • A. Dang
  • D. Robbins
Conference paper
Part of the Research and Perspectives in Alzheimer’s Disease book series (ALZHEIMER)


The MAP kinases ERK1 and ERK2 represent a subfamily of the protein kinases with a significant role in hormonal signal transduction. They are ubiquitous, growth factor-stimulated protein kinases that phosphorylate and thereby modulate the properties of many proteins that have key regulatory functions. These include other protein kinases, transcription factors, membrane enzymes, and cytoskeletal proteins (e.g., tau, MAP2). This wide array of phosphorylations results in their pleiotropic properties. Aberrant activation of the MAP kinases may contribute to pathological changes in the phosphorylation of tau protein associated with Alzheimer’s disease. X-ray crystallographic studies of ERK2 have revealed important features of its phosphoregulatory mechanism and should be valuable in developing specific MAP kinase inhibitors.


PC12 Cell Nerve Growth Factor Dual Specificity Phosphatase Receptor Tyrosine Kinase Signaling Pathway High Affinity Nerve Growth Factor Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • M. H. Cobb
    • 1
  • J. E. Hepler
  • E. Zhen
  • D. Ebert
  • M. Cheng
  • A. Dang
  • D. Robbins
  1. 1.Department of PharmacologyThe University of Texas Southwestern Medical Center at DallasDallasUSA

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