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Tau Variants in Aging and Neurodegenerative Disorders

  • Conference paper
Alzheimer’s Disease: Lessons from Cell Biology

Part of the book series: Research and Perspectives in Alzheimer’s Disease ((ALZHEIMER))

Abstract

One of the main features of many neurodegenerative disorders is the presence of neurofibrillary tangles (NFT) in the cerebral cortex. They are commonly found in Alzheimer’s disease (AD), amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC), dementia pugilistica, head injury, Hallervorden-Spatz disease, post-encephalitic parkinsonism, and progressive supranuclear palsy (PSP) and are frequently observed in Pick’s disease (Hof et al. 1991, 1992a, 1994a; Rewcastle 1991). They are also seen in normal aging (Bouras et al. 1994). In all of these disorders, NFT share similar antigenic properties (Yen et al. 1983; Dickson et al. 1985; Goldman and Yen 1986; Vickers et al. 1992, 1994). Abnormally phosphorylated tau proteins are the main components of the aggregated filaments found in NFT in AD (Grundke-Iqbal et al. 1986; Delacourte et al. 1990; Greenberg et al. 1992). Similar tau immunoreactivity is observed in NFT of most of these neurodegenerative disorders (Pollock et al. 1986; Tabaton et al. 1988; Shankar et al. 1989; Cammarata et al. 1990; Trojanowski et al. 1993). Tau proteins belong to the microtubule-associated proteins family (Weingarten et al. 1975). In the human brain, six isoforms are produced from a single gene by alternative mRNA splicing. They differ from each other by either the presence of three or four microtubule-binding regions in the carboxy-terminal (C-terminal) part of the molecule and one or two inserts in the amino-terminal (N-terminal) part (Goedert et al. 1989; Himmler et al. 1989; Kosik et al. 1989; Lee et al. 1989). The molecular weight of the six isoforms ranges from 45 to 62 kDa when run on polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate.

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References

  • Albert ML, Feldman RG, Willis AL (1974) The “subcortical dementia” of progressive supranuclear palsy. J Neurol Neurosurg Psychiat 37: 121–130

    Article  PubMed  CAS  Google Scholar 

  • Bancher C, Lassman H, Budka H, Grundke-Igbal I, Iqbal K, Wiche G, Seitelberg F, Wiesniewski HM (1987) Neurofibrillary tangles in Alzheimer’s disease and progressive supranuclear palsy: antigenic similarities and differences. Microtubule-associated tau protein is prominent in all types of tangles. Acta Neuropathol 74: 39–46

    Google Scholar 

  • Bouras C, Hof PR, Morrison JH (1993) Neurofibrillary tangle densities in the hippocampal formation in a non-demented population define subgroups of patients with differential early pathologic changes. Neurosci Lett 153: 131–135

    Article  PubMed  CAS  Google Scholar 

  • Bouras C, Hof PR, Giannakopoulos P, Michel J-P, Morrison JH (1994) Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of elderly patients: a quantitative evaluation of a one-year autopsy population from a geriatric hospital. Cerebral Cortex 4: 138–150

    Article  PubMed  CAS  Google Scholar 

  • Braak H, Braak E (1985) On areas of transition between entorhinal allocortex and temporal isocortex in the human brain. Normal morphology and lamina-specific pathology in Alzheimer’s disease. Acta Neuropathol 68: 325–332

    Google Scholar 

  • Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82: 239–259

    Article  PubMed  CAS  Google Scholar 

  • Brion JP, Passareiro H, Nunez J, Flament-Durand J (1985) Immunological detection of tau protein in neurofibrillary tangles of Alzheimer’s disease. Arch Biol 95: 229–235

    Google Scholar 

  • Brody JA, Stanhope JM, Kurland LT (1975) Patterns of amyotrophic lateral sclerosis and parkinsonism-dementia on Guam. In: Hornabrook RW, Davis FA (eds) Topics on tropical neurology, contemporary neurology series, vol 12. Philadelphia, Davis, pp 45–70

    Google Scholar 

  • Buée-Scherrer V, Buée L, Vermersch P, Hof PR, Leveugle B, Loerzel A, Steele JC, Delacourte A, Perl DP (1993) Biochemical characterization of the Tau proteins in amyotrophic lateral sclerosis/parkinsonism dementia complex ( ALS/PDC) of Guam. Soc Neurosci Abstr 19: 195

    Google Scholar 

  • Cammarata S, Mancardi G, Tabaton M (1990) Formic acid treatment exposes hidden neurofilament and tau epitopes in abnormal cytoskeletal filaments from patients with progressive supranuclear palsy and Alzheimer’s disease. Neurosci Lett 115: 351–355

    Article  PubMed  CAS  Google Scholar 

  • Chen KM, Chase TN (1986) Parkinsonism-dementia. In: Vinken PJ, Bruyn GW, Klawans HL (eds) Extrapyramidal disorders. Handbook of clinical neurology, vol 49. Elsevier, Amsterdam, pp 167–183

    Google Scholar 

  • Cummings JL (1988) The dementias of Parkinson’s disease: prevalence, characteristics, neurobiology, and comparison with dementia of the Alzheimer type. Eur Neurol 28: 15–23

    PubMed  Google Scholar 

  • Cummings JL, Benson DF (1984) Subcortical dementia: review of an emerging concept. Arch Neurol 41: 874–879

    PubMed  CAS  Google Scholar 

  • Delacourte A, Défossez A (1986) Alzheimer’s disease: tau proteins, the promoting factors of microtubule assembly are major components of paired helical filaments. J Neurol Sci 76: 173–186

    Article  PubMed  CAS  Google Scholar 

  • Delacourte A, Flament S, Dibe EM, Hublau P, Sablonnière B, Hémon B, Scherrer V, Défossez A (1990) Pathological proteins tau 64 and 69 are specifically expressed in the somatodendritic domain of the degenerating cortical neurons during Alzheimer’s disease: demonstration with a panel of antibodies against tau proteins. Acta Neuropathol 80: 111–117

    Article  PubMed  CAS  Google Scholar 

  • Dickson WD, Kress Y, Crowe A, Yen SH (1985) Monoclonal antibodies to Alzheimer neurofibrillary tangles II: Demonstration of a common antigenic determinant between ANT and neurofibrillary degeneration in progressive supranuclear palsy. Am J Pathol 120: 292–303

    Google Scholar 

  • Dickson WD, Crystal HA, Mattiace LA, Masur DM, Blau AD, Davies P, Yen SH, Aronson MK (1991) Identification of normal and pathological aging in prospectively studied non-demented elderly humans. Neurobiol Aging 13: 179–189

    Article  Google Scholar 

  • Drewes G, Lichtenberg-Kraag B, Döring F, Mandelkow EM, Biernat J, Dorée M, Mandelkow E (1992) Mitogen activated protein ( MAP) kinase transforms tau protein into an Alzheimer-like state. EMBO J 11: 2131–2138

    Google Scholar 

  • Flament S, Delacourte A (1989) Abnormal tau species are produced during Alzheimer’s disease neurodegenerating process. FEBS Lett 247: 213–216

    Article  PubMed  CAS  Google Scholar 

  • Flament S, Delacourte A (1990) Tau marker? Nature 346: 22

    Article  CAS  Google Scholar 

  • Flament S, Delacourte A, Delaère P, Duyckaerts C, Hauw JJ (1990a) Correlation between microscopical changes and tau 64 and 69 biochemical detection in senile dementia of the Alzheimer-type. Tau 64 and 69 are reliable markers of the neurofibrillary degeneration. Acta Neuropathol 80: 212–215

    Article  PubMed  CAS  Google Scholar 

  • Flament S, Delacourte A, Mann DMA (1990b) Phosphorylation of tau proteins: a major event during the process of neurofibrillary degeneration. A comparative study between Alzheimer’s disease and Down’s syndrome. Brain Res 516: 15–19

    Google Scholar 

  • Flament S, Delacourte A, Verny M, Hauw JJ, Javoy-Agid F (1991) Abnormal tau proteins in progressive supranuclear palsy. Similarities and differences with the neurofibrillary degeneration of the Alzheimer type. Acta Neuropathol 81: 591–596

    Google Scholar 

  • Garruto RM, Yase Y (1986) Neurodegenerative disorders of the Western Pacific: the search for mechanisms of pathogenesis. Trends Neurosci 9: 368–371

    Article  Google Scholar 

  • Giannakopoulos P, Hof PR, Mottier S, Michel JP, Bouras C (1994) Neuropathological changes in the cerebral cortex of 1258 cases from a geriatric hospital: retrospective clinicopathological evaluation of a 10-year autopsy evaluation. Acta Neuropathol 87: 456–468

    Article  PubMed  CAS  Google Scholar 

  • Glenner G, Wong CW (1984) Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120: 885–890

    Article  PubMed  CAS  Google Scholar 

  • Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA (1989) Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer’s disease. Neuron 3: 519–526

    Article  PubMed  CAS  Google Scholar 

  • Goedert M, Spillantini MG, Cairns NJ, Crowther RA (1992a) Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms. Neuron 8: 159–168

    Article  PubMed  CAS  Google Scholar 

  • Goedert M, Cohen ES, Jakes R, Cohen P (1992b) p42 MAP kinase phosphorylation sites in microtubule associated protein tau are dephosphorylated by protein phosphatase 2A1. FEBS Lett 312: 95–99

    Google Scholar 

  • Goldman JE, Yen S-H (1986) Cytoskeletal protein abnormalities in neurodegenerative diseases. Ann Neurol 19: 209–223

    Article  PubMed  CAS  Google Scholar 

  • Greenberg SG (1993) Filament-associated tau proteins in neurodegenerative diseases. Soc Neurosci Abstr 19: 196

    Google Scholar 

  • Greenberg SG, Davies P, Scheim JD, Binder LI (1992) Hydrofluoric acid-treated tau-PHF proteins display the same biochemical properties as normal tau. J Biol Chem 267: 564–569

    PubMed  CAS  Google Scholar 

  • Grundke-Iqbal I, Iqbal K, Tung Y-C, Zaidi MS, Wisniewski HM, Binder LI (1986) Abnormal phosphorylation of the microtubule-associated protein tau in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA 83: 4913–4917

    Article  PubMed  CAS  Google Scholar 

  • Gustke N, Steiner B, Mandelkow EM, Biernat J, Meyer HE, Goedert M, Mandelkow E (1992) The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs. FEBS Lett 307: 199–205

    Article  PubMed  CAS  Google Scholar 

  • Hakim AM, Mathieson G (1979) Dementia in Parkinson’s disease: a neuropathological study. Neurology 29: 1209–1214

    PubMed  CAS  Google Scholar 

  • Hanger DP, Hughes K, Woodgett JR, Brion JP, Anderton BH (1992) Glycogen synthase kinase-3 induces Alzheimer’s disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localization of the kinase. Neurosci Lett 147: 58–62

    Article  PubMed  CAS  Google Scholar 

  • Hasegawa M, Morishima-Kawashima M, Takio K, Suzuki M, Titani K, Ihara Y (1992) Protein sequence and mass spectrometric analyses of tau in the Alzheimer’s disease brain. J Biol Chem 267: 17047–17054

    PubMed  CAS  Google Scholar 

  • Hauw JJ, Verny M, Delaère P, Cervera P, He Y, Duyckaerts C (1990) Constant neurofibrillary changes in the neocortex in progressive supranuclear palsy. Basic differences with Alzheimer’s disease and aging. Neurosci Lett 119: 182–186

    Google Scholar 

  • Himmler A, Drechsel D, Kirschner MW, Martin DW Jr (1989) Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains. Mol Cell Biol 9: 1381–1388

    PubMed  CAS  Google Scholar 

  • Hirano A, Kurland LT, Krooth RS, Lessel S (1961) Parkinsonism-dementia complex, and endemic disease on the island of Guam: I. Clinical features. Brain 84: 642–661

    Google Scholar 

  • Hirano A, Malamud N, Elizan TS, Kurland LT (1966) Amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam: further pathological studies. Arch Neurol 15: 35–51

    PubMed  CAS  Google Scholar 

  • Hirano A, Arumugasamy N, Zimmerman HM (1967) Amyotrophic lateral sclerosis: a comparison, of Guam and classical cases. Arch Neurol 16: 357–363

    PubMed  CAS  Google Scholar 

  • Hirano A, Dembitzer HM, Kurland LT, Zimmerman HM (1968) The fine structure of some intraganglionic alterations: neurofibrillary tangles, granulovacuolar bodies and “rod-like” structures in Guam amyotrophic lateral sclerosis and parkinsonism-dementia complex. J Neuropathol Exp Neurol 27: 167–182

    Article  PubMed  CAS  Google Scholar 

  • Hisanaga S-I, Ishiguro K, Uchida T, Okumura E, Okano T, Kishimoto T (1993) Tau protein kinase II has similar characteristic to cdc2 kinase for phosphorylating neurofilament proteins. J Biol Chem 268: 15056–15060

    PubMed  CAS  Google Scholar 

  • Hof PR, Perl D, Loerzel AJ, Morrison JH (1991) Neurofibrillary tangle distribution in the cerebral cortex of parkinsonism-dementia cases from Guam: differences with Alzheimer’s disease. Brain Res 564: 306–313

    Article  PubMed  CAS  Google Scholar 

  • Hof PR, Delacourte A, Bouras C (1992a) Distribution of cortical neurofibrillary tangles in progressive supranuclear palsy: a quantitative analysis of six cases. Acta Neuropathol 84: 45–51

    Article  PubMed  CAS  Google Scholar 

  • Hof PR, Bierer LM, Perl DP, Delacourte A, Buée L, Bouras C, Morrison JH (1992b) Evidence for early vulnerability of the medial and inferior temporal lobe in a 82-year-old patient with possible preclinical signs of dementia: regional and laminar distribution of neurofibrillary tangles and senile plaques. Arch Neurol 49: 946–953

    PubMed  CAS  Google Scholar 

  • Hof PR, Bouras C, Perl DP, Morrison JH (1994a) Quantitative neuropathology analysis of Pick’s disease cases: cortical distribution of Pick bodies and coexistence with Alzheimer’s disease. Acta Neuropathol 87: 115–124

    Article  PubMed  CAS  Google Scholar 

  • Hof PR, Perl DP, Loerzel J, Steele JC, Morrison JH (1994b) Amyotrophic lateral sclerosis and parkinsonism-dementia from Guam: differences in neurofibrillary tangles distribution and density in the hippocampal formation and neocortex. Brain Res 650: 107–116

    Article  PubMed  CAS  Google Scholar 

  • Ishiguro K, Omori A, Kato K, Tomizawa K, Imahori K, Uchida T (1991) A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitope. Neurosci Lett 128: 195–198

    Article  PubMed  CAS  Google Scholar 

  • Ishiguro K, Takamatsu M, Tomizawa K, Omori A, Kato K, Takahashi M, Arioka M, Uchida T, Imahori K (1992) Tau protein Kinase I converts normal tau protein into A68-like component of paired helical filaments. J Biol Chem 267: 10897–10901

    PubMed  CAS  Google Scholar 

  • Ishiguro K, Shiratsuchi A, Sato S, Omori A, Arioka M, Kobayashi SU (1993) Glycogen synthase kinase 3ß is identical to tau protein kinase-I generating several epitopes of paired helical filaments. FEBS Lett 325: 167–172

    Article  PubMed  CAS  Google Scholar 

  • Kidd M (1963) Paired helical filaments in electron microscopy of Alzheimer’s disease. Nature 197: 192–193

    Article  PubMed  CAS  Google Scholar 

  • Kosaka K, Yoshimura M, Ikeda K, Budka H (1984) Diffuse type of Lewy Body disease: progressive dementia with abundant cortical Lewy bodies and senile changes from varying degree — a new disease? Clin Neuropathol 3: 185

    PubMed  CAS  Google Scholar 

  • Kosik KS, Joachim CL, Selkoe DJ (1986) Microtubule associated protein tau is a major antigenic component of paired helical filaments in Alzheimer’s disease. Proc Natl Acad Sci USA 83: 4044–4048

    Article  PubMed  CAS  Google Scholar 

  • Kosik KS, Orecchio LD, Bakalis S, Neve RL (1989) Developmentally regulated expression of specific tau sequences. Neuron 2: 1389–1397

    Article  PubMed  CAS  Google Scholar 

  • Lee G, Neve RL, Kosik KS (1989) The microtubule binding domain of tau protein. Neuron 2: 1615–1624

    Article  PubMed  CAS  Google Scholar 

  • Lee VM-Y, Balin BJ, Otvos Jr L, Trojanowski JO (1991) A68: a major subunit of paired helical filaments and derivatized forms of normal tau. Science 251: 675–678

    Article  PubMed  CAS  Google Scholar 

  • McGeer PL, McGeer EG, Suzuki J, Dolman CE, Nagi T (1984) Aging, Alzheimer’s disease, and the cholinergic system of the basal forebrain. Neurology 34: 741

    Google Scholar 

  • Mandelkow EM, Drewes G, Biernat J, Gustke N, Van Lint J, Vandenheede JR, Mandelkow E (1992) Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau. FEBS Lett 314: 315–321

    Article  PubMed  CAS  Google Scholar 

  • Mann DMA, Tuckert CM, Yates PO (1987) The topographic distribution of senile plaques and neurofibrillary tangles in the brains of non-demented persons at different ages. Neuropathol Appl Neurobiol 13: 123–139

    Article  PubMed  CAS  Google Scholar 

  • Mayeux R, Stern Y, Rosenstein R, Marder K, Hanser A, Cote L, Fahn S (1988) An estimate of the prevalence of dementia in idiopathic Parkinson’s disease. Arch Neurol 45: 260–262

    PubMed  CAS  Google Scholar 

  • Montpetit V, Clapin DF, Guberman A (1985) Substructure of 20-nm filaments of progressive supranuclear palsy. Acta Neuropathol 68: 311–318

    Article  PubMed  CAS  Google Scholar 

  • Pillon B, Dubois B, Lhermitte F, Agid Y (1986) Heterogeneity of cognitive impairment in progressive supranuclear palsy, Parkinson’s disease and Alzheimer’s disease. Neurology 36: 1179–1185

    Google Scholar 

  • Pollock NJ, Mirra SS, Binder LI, Hansen LA, Wood JG (1986) Filamentous aggregates in Pick’s disease, progressive supranuclear palsy, and Alzheimer’s disease show antigenic determinants with microtubule-associated protein tau. Lancet 2: 1211

    Article  PubMed  CAS  Google Scholar 

  • Rewcastle NB (1991) Degenerative diseases of the central nervous system. In: Davis RL, Robertson DM (eds) Textbook of neuropathology, 2nd edn. Williams and Wilkins, Baltimore, pp 903–961

    Google Scholar 

  • Sautière PE, Caillet-Boudin ML, Wattez A, Delacourte A (1994) Detection of Alzheimer-type tau proteins in okadaic acid-treated SKNSH-SY5Y neuroblastoma cells. Neurodegeneration 3: 53–60

    Google Scholar 

  • Shankar S, Yanagihara R, Garruto RM, Grundke-Iqbal I, Kosik KS, Gajdusek DC (1989) Immunocytochemical characterization of neurofibrillary tangles in amyotrophie lateral sclerosis and parkinsonism-dementia on Guam. Ann Neurol 25: 146–151

    Article  PubMed  CAS  Google Scholar 

  • Steele JC, Richardson JC, Olszewski J (1964) Progressive supranuclear palsy. A heterogeneous degeneration involving brain stem, basal ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia. Arch Neurol 10: 333–359

    Google Scholar 

  • Tabaton M, Whitehouse PJ, Perry G, Davies P, Autilio-Gambetti L, Gambetti P (1988) Alz-50 recognizes abnormal filaments in Alzheimer’s disease and progressive supranuclear palsy. Ann Neurol 24: 407–413

    Article  PubMed  CAS  Google Scholar 

  • Takahashi H, Oyanagi K, Takeda S, Hinkuma K, Ikuta F (1989) Occurrence of 15-nm-wide straight tubules in neocortical neurons in progressive supranuclear palsy. Acta Neuropathol 79: 233–239

    Article  PubMed  CAS  Google Scholar 

  • Taylor AE, Saint-Cyr JA, Lang AE (1986) Frontal lobe dysfunction in Parkinson’s disease. The cortical focus of neostriatal outflow. Brain 109: 845–883

    Google Scholar 

  • Tellez-Nagel I, Wisniewski HM (1973) Ultrastructure of neurofibrillary tangles in SteeleRichardson-Olszewski syndrome. Arch Neurol 29: 324–327

    PubMed  CAS  Google Scholar 

  • Tomonaga M (1977) Ultrastructure of neurofibrillary tangles in progressive supranuclear palsy. Acta Neuropathol 37: 177–181

    Article  PubMed  CAS  Google Scholar 

  • Trojanowski JO, Schmidt ML, Shin R-W, Bramblett GT, Rao D, Lee VMY (1993) Altered tau and neurofilament proteins in neurodegenerative diseases: diagnostic implications for Alzheimer’s disease and Lewy body dementias. Brain Pathol 3: 45–54

    Article  PubMed  CAS  Google Scholar 

  • Vandermeeren M, Lübke U, Six J, Cras P (1993) The phosphate inhibitor okadaic acid induces a phosphorylated paired helical filament tau epitope in human LA-N-5 neuroblastoma cells. Neurosci Lett 153: 57–60

    Article  PubMed  CAS  Google Scholar 

  • Vermersch P, Frigard B, Delacourte A (1992a) Mapping of neurofibrillary degeneration in Alzheimer’s disease: evaluation of heterogeneity using the quantification of abnormal tau proteins. Acta Neuropathol 85: 48–54

    Article  PubMed  CAS  Google Scholar 

  • Vermersch P, Frigard B, David JP, Fallet-Bianco C, Delacourte A (1992) Presence of abnormally phosphorylated tau proteins in the entorhinal cortex of aged non-demented subjects. Neurosci Lett 144: 143–146

    Google Scholar 

  • Vermersch P, Delacourte A, Javoy-Agid F, Hauw JJ, Agid Y (1993) Dementia in Parkinson’s disease: biochemical evidence for cortical involvement using the immunodetection of abnormal tau proteins. Ann Neurol 33: 445–450

    Article  PubMed  CAS  Google Scholar 

  • Vermersch P, Robitaille Y, Bernier L, Wattez A, Gauvreau D, Delacourte A (1994) Biochemical mapping of neurofibrillary degeneration in a case of progressive supranuclear palsy: evidence for general cortical involvement. Acta Neuropathol 87: 572–577

    Article  PubMed  CAS  Google Scholar 

  • Vickers JC, Delacourte A, Morrison JH (1992) Progressive transformation of the cytoskeleton associated with normal aging and Alzheimer’s disease. Brain Res 594: 273–278

    Article  PubMed  CAS  Google Scholar 

  • Vickers JC, Riederer BM, Marugg MA, Buée-Scherrer V, Buée L, Delacourte A, Morrison JH (1994) Alterations in neurofilament protein immunoreactivity in human hippocampal neurons related to normal aging and Alzheimer’s disease. Neuroscience 62: 1–13

    Article  PubMed  CAS  Google Scholar 

  • Vincent I, Rosado M, Kim E, Davies P (1994) Increased production of paired helical filament epitopes in a cell culture system reduces the turnover of tau. J Neurochem 62: 715–723

    Article  PubMed  CAS  Google Scholar 

  • Vulliet R, Halbran SM, Braun RK, Smith AJ, Lee G (1992) Proline-directed phosphorylation of human tau protein. J Biol Chem 267: 22570–22574

    PubMed  CAS  Google Scholar 

  • Weingarten MD, Lockwood AH, Hwo S-H, Kirschner MW (1975) A protein factor essential for microtubule assembly. Proc Natl Acad Sci USA 72: 1858–1862

    Article  PubMed  CAS  Google Scholar 

  • Wisniewski HM, Rabe A, Zigman W, Silverman W (1989) Neuropathological diagnosis of Alzheimer’s disease. J Neuropathol Exp Neurol 48: 606–609

    Article  PubMed  CAS  Google Scholar 

  • Yen SH, Horoupian DS, Terry RD (1983) Immunocytochemical comparison of neurofibrillary tangles in senile dementia of Alzheimer type, progressive supranuclear palsy and post-encephalitic parkinsonism. Ann Neurol 13: 172–175

    Article  PubMed  CAS  Google Scholar 

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  1. INSERM U422, Place de Verdun, 59045, Lille Cédex, France

    A. Delacourte

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  1. V. Buée-Scherrer
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  2. L. Buée
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  3. P. R. Hof
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  1. Harvard Medical School, Brigham and Women’s Hospital, 221 Longwood Avenue, 02115, Boston, MA, USA

    K. S. Kosik M.D. (Associate Professor of Neurology and Neuroscience) & D. J. Selkoe M.D. (Professor of Neurology and Neuroscience) (Associate Professor of Neurology and Neuroscience) &  (Professor of Neurology and Neuroscience)

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    Y. Christen Ph.D.

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Buée-Scherrer, V. et al. (1995). Tau Variants in Aging and Neurodegenerative Disorders. In: Kosik, K.S., Selkoe, D.J., Christen, Y. (eds) Alzheimer’s Disease: Lessons from Cell Biology. Research and Perspectives in Alzheimer’s Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79423-0_12

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