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Pathways for Cytolysis pp 1–24Cite as

Perforin and Granzymes: Crucial Effector Molecules in Cytolytic T Lymphocyte and Natural Killer Cell-Mediated Cytotoxicity

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 198))

Abstract

The killing mediated by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells represents an important mechanism in the immune defense against tumors, virus-infected cells, parasites and other foreign invaders. The deleterious effects observed in the absence of a properly working cellular immune response have been characterized extensively in immunodeficient patients (for a review see Matsumoto et al. 1992) and naturally occurring animal models such as SCID (severe combined immunodeficiency) or nude mice. In general, immunodeficient individuals are predisposed to develop severe opportunistic infections which ultimately can lead to their death. Recently, gene targeting technology has been used repeatedly to generate mice with defined mutations in genes implicated in T and NK cell function (for a review see Yeung et al. 1993), in an attempt to dissect the individual pathways involved in the lymphocyte-mediated immune response.

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  1. M. C. Peitsch

    Present address: Glaxo Institute for Molecular Biology, 1021, Plan-Les-Ouates, Switzerland

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  1. Institute of Biochemistry, University of Lausanne, Ch. des Boveresses, 155, 1066, Epalinges, Switzerland

    B. Lowin, M. C. Peitsch & J. Tschopp

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  1. Basel Institute of Immunology, Grenzacherstr. 487, 4005, Basel, Switzerland

    Gillian M. Griffiths

  2. Department of Biochemistry, University of Lausanne, Ch. Boveresses 155, 1066, Epalinges/Lausanne, Switzerland

    Jürg Tschopp

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Lowin, B., Peitsch, M.C., Tschopp, J. (1995). Perforin and Granzymes: Crucial Effector Molecules in Cytolytic T Lymphocyte and Natural Killer Cell-Mediated Cytotoxicity. In: Griffiths, G.M., Tschopp, J. (eds) Pathways for Cytolysis. Current Topics in Microbiology and Immunology, vol 198. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79414-8_1

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  • DOI: https://doi.org/10.1007/978-3-642-79414-8_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79416-2

  • Online ISBN: 978-3-642-79414-8

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