Improvements in patient assessment and treatment of Hodgkin disease allow us now to cure the majority of patients with this disease. These improved results have minimised the impact of prognostic factors and, currently, prognostic factors are employed more frequently to select therapy than to estimate survival. Over the last three decades, numerous factors have been shown to affect the prognosis of patients with Hodgkin disease. Most of these factors are highly interrelated. Consequently, multivariate analyses are needed to determine which factors are merely related to better known prognostic factors, but are without independent prognostic significance. A large number of multivariate studies of prognostic factors in Hodgkin disease have been published. The differing conclusions may be attributed to variation with regard to factors being examined, patient assessment and treatment, and the methods of analysis employed in individual studies. A comprehensive review of the literature on prognostic factors in Hodgkin disease emphasised both the wealth of data and differences in opinion due to the differences in recording and analysis of prognostic factors .
KeywordsAlbumin Lymphoma Sedimentation Oncol Ferritin
Unable to display preview. Download preview PDF.
- 11.Gobbi PG, Cavalli C, Federico M Et Al (1988) Hodgkin’s disease prognosis: a directly predictive equation. Lancet I: 675–679Google Scholar
- 14.Haybittle JL, Haygoe FGJ, Easterling M J Et Al (1985) Review of British National Lymphoma Investigation studies of Hodgkin’s disease and development of prognostic index. Lancet I: 967–972Google Scholar
- 15.Henry-Amar M, Aeppli DM, Anderson J Et Al (1990) Workshop statistical report. In: Somers R, Henry-Amar M, Meerwaldt JK Et Al (eds) Treatment strategy in Hodgkin’s disease. INSERM/ John Libbey Eurotext, London, pp 169–422Google Scholar
- 16.Hermanek P, Sobin LH (eds) (1992) UICC TNM classification of malignant tumours, 4th edn, 2nd rev. Springer, Berlin Heidelberg New YorkGoogle Scholar
- 19.Jafîe HS, Cadman EC, Farber LR Et Al (1986) Pretreatment hematocrit as an independent prognostic variable in Hodgkin’s disease. Blood 68: 562–564Google Scholar
- 20.Kaplan HS (1980) Hodgkin’s disease, 2nd edn. Harvard University Press, CambridgeGoogle Scholar
- 22.Loffler M, Dixon DO, Swindell R (1990) Prognostic factors of stage III and IV Hodgkin’s disease. In: Somers R, Henry-Amar M, Meerwaldt JK Et Al (eds) Treatment strategy in Hodgkin’s disease. John Libbey Eurotext, Paris, pp 90–103Google Scholar
- 24.Lukes RJ, Craver LF, Hall TC Et Al (1966) Report of the Nomenclature Committee. Cancer Res 26: 1311Google Scholar
- 25.MacLennan KA, Bennett MH, Bosq J Et Al (1990) The histology and immunohistology of Hodgkin’s disease: its relationship to prognosis and clinical behaviour. In: Somers R, Henry- Amar M, Meerwaldt JK Et Al (eds) Treatment strategy in Hodgkin’s disease. John Libbey Eurotext, Paris, pp 17–25Google Scholar
- 28.Meerwaldt JH, Van Glabbeke M, Vaughan Hudson B (1990) Prognostic factors for stage I and II Hodgkin’s disease. In: Somers R, Henry-Amar M, Meerwaldt JK Et Al (eds) Treatment strategy in Hodgkin’s disease. John Libbey Eurotext, Paris, pp 37–50Google Scholar
- 30.Peters MV (1950) A study of survivals in Hodgkin’s disease treated radiologically. Am J Roentgenol 63: 299–311Google Scholar
- 31.Peters MV, Middlemiss KCH (1958) A study of Hodgkin’s disease treated by irradiation. Am J Roentgenol 79: 114–121Google Scholar
- 49.Verger E, Easton D, Brada M Et Al (1988) Radiotherapy results in laparotomy staged Hodgkin’s disease. Clin Oncol 39: 428–431.Google Scholar