Improvements in patient assessment and treatment of Hodgkin disease allow us now to cure the majority of patients with this disease. These improved results have minimised the impact of prognostic factors and, currently, prognostic factors are employed more frequently to select therapy than to estimate survival. Over the last three decades, numerous factors have been shown to affect the prognosis of patients with Hodgkin disease. Most of these factors are highly interrelated. Consequently, multivariate analyses are needed to determine which factors are merely related to better known prognostic factors, but are without independent prognostic significance. A large number of multivariate studies of prognostic factors in Hodgkin disease have been published. The differing conclusions may be attributed to variation with regard to factors being examined, patient assessment and treatment, and the methods of analysis employed in individual studies. A comprehensive review of the literature on prognostic factors in Hodgkin disease emphasised both the wealth of data and differences in opinion due to the differences in recording and analysis of prognostic factors .
KeywordsPrognostic Factor Combine Modality Therapy Hodgkin Disease Mixed Cellularity Independent Prognostic Significance
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