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Prognostic Factors in Cancer pp 138–148Cite as

Soft Tissue Sarcomas in Adults

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Abstract

Soft tissue sarcomas (STS) in adults (age 16 years or more) are a heterogeneous group of malignant tumours showing great variations in histological type and grade, clinical presentation, site and biological behaviour. These tumours are relatively uncommon, and the number of patients treated at an individual institution is usually limited. Furthermore, treatment strategies vary, thus adequate experience with these tumours is restricted to relatively few centres.

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References

  1. Abbatucci JS, Boulier N, De Ranieri J, Mandard AM, Tanguy A, Vernhes JC, Busson A (1986) Local control and survival in soft tissue sarcomas of the limbs, trunk walls and head and neck. Int J Radiat Oncol Biol Phys 12: 579–586

    Article  PubMed  CAS  Google Scholar 

  2. American Joint Committee for Cancer Staging and End-Results Reporting (AJC) (1977) Manual for staging of cancer. AJC, Chicago

    Google Scholar 

  3. Alvegard TA, Berg NO, Baldetorp B, Ferno M, Killander D, Ranstam J, Rydholm A, Akerman M (1990) Cellular DNA content and prognosis of high-grade soft tissue sarcoma: the Scandina¬vian Sarcoma Group experience. J Clin Oncol 8: 538–547

    PubMed  CAS  Google Scholar 

  4. Barkley HT, Martin RG, Romsdahl MM, Lindberg HL, Zagars GK (1988) Treatment of soft tissue sarcomas by preoperative irradiation and conservative surgical resection. Int J Radiat Oncol Biol Phys 14: 693–699

    Article  PubMed  Google Scholar 

  5. Barrios C, Castresana JS, Ruiz J, Kreicbergs A (1994) Amplification of the c-myc proto- oncogene in soft tissue sarcomas. Oncology 51: 13–17

    Article  PubMed  CAS  Google Scholar 

  6. Beahrs OH, Henson DE, Hutter RVP, Kennedy BJ (eds) (1992) American Joint Committee on Cancer (AJCC): Manual for staging of cancer, 4th edn. Lippincott, Philadelphia

    Google Scholar 

  7. Berlin Ö, Stener B, Angervall L, Kindblom LG, Markhede G, Oden A (1990) Surgery for soft tissue sarcomas in the extremities. Acta Orthop Scand 61: 475–486

    Article  PubMed  CAS  Google Scholar 

  8. Brant TA, Parsons JT, Marcus jr RB, Spanier SS, Heare TV, van der Griend RA, Enneking WK, Million RR (1992) Preoperative irradiation for soft tissue sarcomas of the trunk and extremities in adults. Int J Radiat Oncol Biol Phys 19: 899–906

    Google Scholar 

  9. Brennan MF, Casper ES, Harrison LB, Shiu MH, Gaynor J, Hajdu SI (1991) The role of multimodality therapy in soft tissue sarcoma. Ann Surg 214: 328–338

    Article  PubMed  CAS  Google Scholar 

  10. Cance WG, Brennan MF, Dudas ME, Huang CM, Cordon-Cardo C (1990) Altered expression of the retinoblastoma gene product in human sarcomas. N Engl J Med 323: 1457–1462

    Article  PubMed  CAS  Google Scholar 

  11. Chang HR, Gaynor J, Tan C, Hajdu SI, Brennan MF (1990) Multifactorial analysis of survival in primary extremity liposarcoma. World J Surg 14: 610–618

    Article  PubMed  CAS  Google Scholar 

  12. Collin C, Godbold J, Hajdu S, Brennan M (1987) Localized extremity soft tissue sarcoma: an analysis of factors affecting survival. J Clin Oncol 5: 601–612

    PubMed  CAS  Google Scholar 

  13. Eeles RA, Fisher C, A’Hern RP, Robinson M, Rhys-Evans P, Henk JN, Archer D, Harmer CL (1993) Head and neck sarcomas: prognostic factors and implications for treatment. Br J Cancer 68: 201–207

    Article  PubMed  CAS  Google Scholar 

  14. Elias AD (1993) Chemotherapy for soft-tissue sarcomas. Clin Orthop 289: 94 - 105

    PubMed  Google Scholar 

  15. El-Jabbour JN, Akhtar SS, Kerr GR, McLaren KM, Smyth JF, Rodger A, Leonard RCF (1990) Prognostic factors for survival in soft tissue sarcoma. Br J Cancer 62: 857–861

    Article  PubMed  CAS  Google Scholar 

  16. Enneking WF, Spanier SS, Malawer MM (1981) The effect of anatomic setting on the results of surgical procedures for soft part sarcomas of the thigh. Cancer 47: 1005–1022

    Article  PubMed  CAS  Google Scholar 

  17. Enzinger FM, Weiss SW (1988) Soft tissue sarcomas, 2nd edn. Mosby, St Louis

    Google Scholar 

  18. Geer RJ, Woodruff J, Casper ES, Brennan MF (1992) Management of small soft-tissue sarcoma of the extremity in adults. Arch Surg 127: 1285–1289

    PubMed  CAS  Google Scholar 

  19. Hajdu SI (1985) Differential diagnosis of soft tissue and bone tumors. Lea and Febiger, Philadelphia

    Google Scholar 

  20. Hashimoto H, Daimaru Y, Takeshita A, Tsuneyoshi M, Enjoji M (1992) Prognostic significance of histologic parameters of soft tissue sarcomas. Cancer 70: 2816–2822

    Article  PubMed  CAS  Google Scholar 

  21. Herbert SH, Corn BW, Soling LJ, Lanciano MM, Schultz DJ, Gillies McKenna W, Coia LR (1993) Limb-preserving treatment for soft tissue sarcomas of the extremities. Cancer 72: 1230–1238

    Article  PubMed  CAS  Google Scholar 

  22. Hermanek P, Sobin LH (eds) (1992) UICC: TNM classification of malignant tumours, 4th edn, 2nd rev. Springer, Berlin Heidelberg New York

    Google Scholar 

  23. Hohenberger W, Göhl J, Kessler C, Hermanek P (1990) Behandlung von Weichteilsarkomen. Ein Erfahrungsbericht anhand des Erlanger Krankengutes. In: Gall FP, Göhl J, Hohenberger W (eds) Weichteilsarkome. Zuckschwerdt, Munich

    Google Scholar 

  24. Jensen OM, Hogh J, Ostgaard SE, Nordentoft AM, Sneppen O (1991) Histopathological grading of soft tissue tumors. Prognostic significance in a prospective study of 278 consecutive cases. J Pathol 163: 19–24

    Article  PubMed  CAS  Google Scholar 

  25. Karakousis CP, Emrich LJ, Rao U, Krishnamsetty RM (1986) Feasibility of limb salvage and survival in soft tissue sarcomas. Cancer 56: 484–491

    Article  Google Scholar 

  26. Katenkamp D, Hünerbein R (1992) Untersuchungen zur prognostischen Bedeutung von Entzündungszellen in malignen Weichgewebstumoren des Menschen. Zentralbl Pathol 138: 21–25

    PubMed  CAS  Google Scholar 

  27. Kawai A, Noguchi M, Beppu J, Yokoyama R, Mukai K, Hiroshashi S, Inoue H, Fukuma H (1994) Nuclear immunoreaction of p53 protein in soft tissue sarcomas. Cancer 73: 2499–2505

    Article  PubMed  CAS  Google Scholar 

  28. Kraus DH, Dubner S, Harrison LB, Strong EW, Hajdu SI, Kher U, Begg C, Brennan MF (1994) Prognostic factors of recurrence and survival in head and neck soft tissue sarcomas. Cancer 74: 697–702

    Article  PubMed  CAS  Google Scholar 

  29. Lack EE, Steinberg SM, White DE, Kinsella T, Glatstein E, Chang AE, Rosenberg SA (1989) Extremity soft tissue sarcomas: analysis of prognostic variables in 300 cases and evaluation of tumor necrosis as a factor in stratifying higher-grade sarcomas. J Surg Oncol 41: 263–273

    Article  PubMed  CAS  Google Scholar 

  30. Leibel SA, Tranbaugh RF, Wara WM, Beckstead JH, Bovill EG, Phillips TL (1982) Soft tissue sarcomas of the extremities. Cancer 50: 1076–1083

    Article  PubMed  CAS  Google Scholar 

  31. Lindberg RD, Martin RG, Romsdahl MM, Barkley HT (1981) Conservative surgery and postoperative radiotherapy in 300 adults with soft tissue sarcomas. Cancer 47: 2391–2397

    Article  PubMed  CAS  Google Scholar 

  32. Mandard AM, Petiot JF, Maraay J, Mandard JC, Chasle J, De Ranieri E, Dupin P, Herlin P, De Ranieri J, Tanguy A, Boulier N, Abbatucci JS (1989) Prognostic factors in soft tissue sarcomas. Cancer 63: 1437–1451

    Article  PubMed  CAS  Google Scholar 

  33. Menon AG, Anderson KM, Riccardi VM, Chang RV, Whaley JM, Yandell DW (1990) Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis. Proc Natl Acad Sci USA 87: 5435–5439

    Article  PubMed  CAS  Google Scholar 

  34. Mertens WC, Bramwell VH (1993) Adjuvant chemotherapy in the treatment of soft tissue sarcomas. Clin Orthop 289: 81–93

    PubMed  Google Scholar 

  35. Porter PL, Gown AM, Kramp SG, Coltera MD (1992) Widespread p53 overexpression in human malignant tumors. Am J Pathol 140: 145–153

    PubMed  CAS  Google Scholar 

  36. Potter DA, Kinsella T, Glatstein E, Wesley R, White DE, Seipp CA, Chang AE, Lack EE, Costa J, Rosenberg SA (1986) High-grade soft tissue sarcomas of the extremities. Cancer 58: 190–205

    Article  PubMed  CAS  Google Scholar 

  37. Ravaud A, Bui NB, Coindre JM, Lagarde P, Tramond P, Bonichon F, Stockle E, Kantor G, Trojani M, Chauvergne J, Maree D (1992) Prognostic variables for the selection of patients with operable soft tissue sarcomas to be considered in adjuvant chemotherapy trials. Br J Cancer 66: 961–969

    Article  PubMed  CAS  Google Scholar 

  38. Reissmann PT, Simon MA, Lee WH, Slamon D (1989) Studies of the retinoblastoma gene in human sarcomas. Oncogene 4: 839–843

    PubMed  CAS  Google Scholar 

  39. Rooser BO, Berg NO, Ranstam J, Rydholm A, Willen H (1990) Prediction of survival in patients with high-grade soft tissue sarcoma. Int Orthop 14: 199–204

    Article  PubMed  CAS  Google Scholar 

  40. Saddegh MK, Lindholm J, Lundberg A, Nilsome U, Kreicbergs A (1992) Staging of soft-tissue sarcomas. Prognostic analysis of clinical and pathological features. J Bone Joint Surg 74B: 495–500

    Google Scholar 

  41. Schmidt RA, Conrad EU, Collins C, Rabinovitch P, Finney A (1993) Measurement and prediction of the short-term response of soft tissue sarcomas to chemotherapy. Cancer 72: 2593–2601

    Article  PubMed  CAS  Google Scholar 

  42. Serpell JW, Ball BS, Robinson MH, Fryatt I, Fischer C, Thomas JM (1991) Factors influencing local recurrence and survival in patients with soft tissue sarcoma of the upper limb. Br J Surg 78: 1368–1372

    Article  PubMed  CAS  Google Scholar 

  43. Shiu MH, Castro EB, Hajdu SI, Fortner JG (1975) Surgical treatment of 297 soft tissue sarcomas of the lower extremity. Ann Surg 182: 172–179

    Article  Google Scholar 

  44. Stenfert Kroese MC, Rutgers DH, Wils IS, van Unnik JAM, Rokoll PJM (1990) The relevance of the DNA index and proliferation rate in the grading of benign and malignant soft tissue tumors. Cancer 65: 1782–1788

    Article  PubMed  CAS  Google Scholar 

  45. Stotter AT, A’Hern RP, Fisher C, Mott AF, Fallowfield M, Westbury G (1990) The influence of local recurrence of extremity soft tissue sarcoma on metastasis and survival. Cancer 65: 1119–1129

    Article  PubMed  CAS  Google Scholar 

  46. Stratton MR, Moss S, Warren W, Patterson H, Clark H, Fisher C, Fletcher CDM, Ball A, Thomas M, Gusterson BA, Cooper CS (1990) Mutation of the p53 gene in human soft tissue sarcomas: association with abnormalities of the RBI gene. Oncogene 5: 1297–1301

    PubMed  CAS  Google Scholar 

  47. Suit HD, Mankin HJ, Wood WC, Proppe KH (1985) Preoperative, intraoperative and postoperative radiation in the treatment of primary soft tissue sarcoma. Cancer 55: 2659–2667

    Article  PubMed  CAS  Google Scholar 

  48. Suit HD, Mankin HJ, Willert CG, Gebhardt MC, Wood WC, Skates S (1988) Limited surgery and external irradiation in soft tissue sarcomas. In: Ryan JR, Baker LH (eds) Recent concepts in sarcoma treatment. Kluwer Academic, Dorddrecht

    Google Scholar 

  49. Suit HD, Mankin HJ, Wood WC, Gebhardt MC, Harmon DC, Rosenberg A, Tepper JE, Rosenthal D (1988) Treatment of the patient with stage M0 soft tissue sarcoma. J Clin Oncol 6: 854–862

    PubMed  CAS  Google Scholar 

  50. Suit HD, Proppe KH, Mankin HG, Wood WC (1981) Preoperative radiation therapy for sarcoma of soft tissue. Cancer 47: 2269–2274

    Article  PubMed  CAS  Google Scholar 

  51. Tanabe KK, Pollock RE, Ellis LM, Murphy A, Sherman N, Romsdahl NM (1994) Influence of surgical margins on outcome in patients with preoperatively irradiated extremity soft tissue sarcomas. Cancer 73: 1652–1659

    Article  PubMed  CAS  Google Scholar 

  52. Tawa A, Inoue M, Ishihara S, Hara J, Yumura-Yagi K, Okada A, Nihei A, Taguchi J, Kanai N, Tsuruo T, Kawa-Ha K (1990) Increased expression of the multidrug-resistance gene in undifferentiated sarcoma. Cancer 66: 1980–1983

    Article  PubMed  CAS  Google Scholar 

  53. Tetu B, Lacasse B, Bouchard HL, Lagace R, Hout J, Landry J (1992) Prognostic influence of HSP-27 expression in malignant fibrous histiocytoma: a clinicopathological and immunohisto- chemical study. Cancer Res 52: 2325–2328

    PubMed  CAS  Google Scholar 

  54. Tran LM, Mark R, Meier R, Calcaterra T, Parker RG (1992) Sarcomas of the head and neck. Prognostic factors and treatment strategies. Cancer 70: 169–177

    Google Scholar 

  55. Tsujimoto M, Aozasa K, Ueda T, Morimura Y, Komatsubara Y, Doi T (1988) Multivariate analysis for histologic prognostic factors in soft tissue sarcomas. Cancer 62: 994–998

    Article  PubMed  CAS  Google Scholar 

  56. Ueda T, Aozasa K, Tsujimoto M, Hamada H, Hayashi H, Ono K, Matsumoto K (1988) Multivariate analysis for clinical prognostic factors in 163 patients with soft tissue sarcoma. Cancer 62: 1444–1450

    Article  PubMed  CAS  Google Scholar 

  57. Ueda T, Aozasa K, Tsujimoto M, Ohsawa M, Uchida A, Aoki J, Ono K, Matsumoto K (1989) Prognostic significance of Ki-67 reactivity in soft tissue sarcomas. Cancer 63: 1607–1611

    Article  PubMed  CAS  Google Scholar 

  58. Weiss SW in collaboration with LH Sobin and pathologists in 9 countries (1994) Histological typing of soft tissue tumors, 2nd edn. Springer, Berlin Heidelberg New York

    Google Scholar 

  59. Wunder JS, Czitrom A A, Kandel R, Andrulis IL (1991) Analysis of alterations in the retinoblastoma gene and tumor grade in bone and soft-tissue sarcomas. J Natl Cancer Inst 83: 194–200

    Article  PubMed  CAS  Google Scholar 

  60. Yang JC, Glatstein EJ, Rosenberg SA, Antman KH (1993) Sarcomas of soft tissues. In: de Vita VT Jr, Hellmann S, Rosenberg SA (eds) Cancer. Principles and practice of oncology, 4th edn. Lippincott, Philadelphia

    Google Scholar 

  61. Zalupski MM, Macioroaski Z, Ryan JR, Ansley JF, Hussein ME, Sundareson AS, Baker LH (1993) DNA content parameters of paraffin-embedded soft tissue sarcomas: optimization of retrieval technique and comparison to fresh tissue. Cytometry 14: 327–333

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. S. Toma
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  2. W. Hohenberger
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  3. R. Palumbo
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  4. O. Schmidt
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  5. G. Nicolò
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Editor information

Editors and Affiliations

  1. Chirurgische Universitätsklinik Erlangen, Krankenhausstr. 12, 91054, Erlangen, Germany

    P. Hermanek (Vorstand der Abteilung für Klinische Pathologie i. R.) (Vorstand der Abteilung für Klinische Pathologie i. R.)

  2. Princess Margaret Hospital, Department of Radiation Oncology, University of Toronto, 500 Sherbourne Street, Toronto, Ontario, M4X 1K9, Canada

    Mary K. Gospodarowicz

  3. Early Detection Branch, Division of Cancer Prevention and Control, National Cancer Institute, EPN Building, Room 305 9000 Rockville Pike, Bethesda, MD, 20892, USA

    D. E. Henson

  4. University of Medicine and Dentistry, New Jersey Medical School, Newark, NJ, USA

    R. V. P. Hutter (Clinical Professor of Pathology) (Clinical Professor of Pathology)

  5. Department of Pathology, Saint Barnabas Medical Center, Old Short Hills Road, Livingston, NJ, 07039, USA

    R. V. P. Hutter (Clinical Professor of Pathology) (Clinical Professor of Pathology)

  6. Uniformed Services University of the Health Sciences, Bethesda, MD, USA

    L. H. Sobin (Professor of Pathology) (Professor of Pathology)

  7. Division of Gastrointestinal Pathology, Armed Forces Institute of Pathology, Washington, DC, 20306, USA

    L. H. Sobin (Professor of Pathology) (Professor of Pathology)

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© 1995 International Union Against Cancer, Geneva

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Toma, S. et al. (1995). Soft Tissue Sarcomas in Adults. In: Hermanek, P., Gospodarowicz, M.K., Henson, D.E., Hutter, R.V.P., Sobin, L.H. (eds) Prognostic Factors in Cancer. UICC International Union Against Cancer / Union Internationale Contre le Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79395-0_15

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  • DOI: https://doi.org/10.1007/978-3-642-79395-0_15

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  • Print ISBN: 978-3-540-58688-3

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