Skip to main content
SpringerLink
Log in

Lung Carcinoma

  • Chapter
Prognostic Factors in Cancer

Abstract

When we analyze the prognostic factors in lung carcinoma, two major issues must be taken into consideration: tumour histology and stage of the disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Albain KS, Crowley JJ, LeBlanc M, Livingston RB (1990) Determinants of improved outcome in small-cell lung cancer: an analysis of the 2580-patient Southwest Oncology Group data base. J Clin Oncol 8: 1563–1574

    PubMed  CAS  Google Scholar 

  2. American Joint Committee for Cancer Staging and End-Results Reporting (1978) Manual for staging of cancer 1978. American Joint Committee, Chicago

    Google Scholar 

  3. American Joint Committee on Cancer (AJCC) (1992) Manual for staging of cancer. 4th edn. ( Beahrs OH, Henson DE, Hutter RVP, Kennedy BJ, Eds). Lippincott, Philadelphia

    Google Scholar 

  4. Asamura H, Nakajima T, Mukai K, Shimosato Y (1991) Nuclear DNA content by cytofluorometry of stage I adenocarcinoma of the lung in relation to postoperative recurrence. Chest 96: 312–318

    Article  Google Scholar 

  5. Cibas ES, Melamed MR, Zaman MB, Kimmel M (1988) The effect of tumour size and tumour cell DNA content on the survival of patients with stage I adenocarcinoma of the lung. Cancer 63: 1552–1556

    Article  Google Scholar 

  6. Einhorn LH, Lohrer PJ, Williams SD, Meyers S, Gabrys T, Nottan SR, Woodburn R, Drasga R, Songer I, Fisher W, Stephens D, Hui S (1986) Random prospective study of vindesine versus vindesine plus high-dose cisplatin versus vindesine plus cisplatin plus mitomycin C in advanced non-small-cell lung cancer. J Clin Oncol 4: 1037–1043

    PubMed  CAS  Google Scholar 

  7. Evans WK, Nikon DW, Dally JM, Ellen SS, Gardner L, Wolfe E, Shepherd FA, Feld R, Gralla R, Fine S, Chimney N, Jeejeebhoy KH, Heymsfield S, Hoffman FA (1987) A randomized study of oral nutritional support versus ad lib nutritional intake during chemotherapy for advanced colorectal and non-small-cell lung cancer. J Clin Oncol 5: 113–124

    PubMed  CAS  Google Scholar 

  8. Feinstein AR, Wells CK (1986) A clinical-severity staging system for patients with lung cancer. Medicine 69: 1–33

    Google Scholar 

  9. Finkelstein DM, Eittinger DS, Ruckedschel JC (1986) Long term survivors in metastatic non- small-cell lung cancer: an Eastern Cooperative Oncology Group study. J Clin Oncol 4: 702–709

    PubMed  CAS  Google Scholar 

  10. Gail MH, Eagan RT, Feld R, Ginsberg R, Goodell B, Hill L, Holmes CE, Lukeman JM, Mountain CF, Olkham RK, Pearson FG, Wright PW, Lake WH (1984) Prognostic factors in patients with resected stage I non-small cell lung cancer: a report from the Lung Cancer Study Group. Cancer 54: 1802–1813

    Article  PubMed  CAS  Google Scholar 

  11. Hermanek P, Sobin LH (eds) (1992) UICC TNM classification on malignant tumours. 4th edn, 2nd revision 1992. Springer, Berlin Heidelberg New York

    Google Scholar 

  12. Hirohashi S, Ino Y, Kodama T, Shimosato Y (1984) Distribution of blood group antigens A, B, H, and I ( Ma) in mucus-producing adenocarcinoma of human lung. J Natl Cancer Inst 72: 1299–1305

    Google Scholar 

  13. Hiyoshi H, Matsuno Y, Kato H, Shimosato Y, Hirohashi S (1992) Clinicopathological significance of nuclear accumulation of tumour suppressor gene p53 product in primary lung cancer. Jpn J Cancer Res 83: 101–106

    Article  PubMed  CAS  Google Scholar 

  14. Horio Y, Takahashi T, Kuroishi T, Hibi K, Suyama M, Niimi T, Shimokata K, Yamakawa K, Nakamura Y, Ueda R (1993) Prognostic significance of p53 mutations and 3p deletions in primary resected non-small cell lung cancer. Cancer Res 53: 1–4

    PubMed  CAS  Google Scholar 

  15. Ichinose Y, Hara N, Ohta M, Yano T, Maeda K, Asoh H, Katsuda Y (1993) Is T factor of the TNM staging system a predominant prognostic factor in pathologic factor analysis of 151 patients. J Thorac Cardiovasc Surg 106: 90–94

    PubMed  CAS  Google Scholar 

  16. Johnson BE, Steinberg SM, Phelps R, Edison M, Veach SR, Ihde DC (1988) Female patients with small cell lung cancer live longer than male patients. Am J Med 85: 194–196

    Article  PubMed  CAS  Google Scholar 

  17. Kaneko S, Ishida T, Sugio K, Yokoyama H, Sugimachi K (1991) Nucleolar organizer regions as a prognostic indication for stage I non-small cell lung cancer. Cancer Res 51: 4008–4011

    PubMed  CAS  Google Scholar 

  18. Karnofsky DA, Abelmatfn WH, Craver LF, Burchenal JH (1948) The use of nitrogen mustards in the palliative treatment of cancer. Cancer 1: 634–656

    Article  Google Scholar 

  19. Kobayashi T, Tsuda H, Noguchi M (1990) Association of point mutation in c-Ki-ras oncogene in lung adenocarcinoma with particular reference to cytologic subtypes. Cancer 66: 289–294

    Article  PubMed  CAS  Google Scholar 

  20. Lanzotte VJ, Thomas DR, Boyle LE, Smith TL, Gehan EA, Samuels MS (1977) Survival with inoperable lung cancer. An integration of prognostic variables based on simple clinical criteria. Cancer 39: 303–313

    Google Scholar 

  21. Lee JS, Ro Jy, Sahin AA, Hong WK, Brown BW, Mountain CF, Hittelman WN (1991) Expression of blood-group antigen A. A favorable prognostic factor in non-small cell lung cancer. N Engl J Med 324: 1084–1090

    Google Scholar 

  22. Lenhard RE, Woo KB, Abeloif MD (1983) Predictive value of regression rate following chemotherapy of small cell carcinoma of the lung. Cancer Res 43: 3013–3017

    PubMed  Google Scholar 

  23. Lipford EH, Sears DL, Eggleston JC, Moore GW, Lillemore KD, Baker RR (1984) Prognostic factors in surgically resected limited-stage, non-small-cell carcinoma of the lung. Am J Surg Pathol 8: 357–365

    Article  PubMed  Google Scholar 

  24. Miller TP, Chen TT, Coltman CA, O’Bryan RM, Vance RB, Weiss GB, Fletcher WS, Stephens RI, Livingston RB (1986) Effect of alternation combination chemotherapy on survival of ambulatory patients with metastatic large-cell and adenocarcinoma of the lung. A Southwest Oncology Group Study. J Clin Oncol 4: 1037–1043

    Google Scholar 

  25. Mountain CF (1986) A new international staging system for lung cancer. Chest 89 [Suppl]: 225s–233s

    Google Scholar 

  26. Mountain CF, Lukeman JM, Hammar SP, Chamberlain DW, Coulsen SP, Page DL, Victor TA, Weiland LH, and the Lung Cancer Study Group Pathology Committee (1987) Lung cancer classification: the relationship of disease extent and cell type to survival in a clinical trial population. J Surg Oncol 35: 147–156

    Article  Google Scholar 

  27. Naruke T, Goya T, Tsuchiya R, Suemasu K (1988). Prognosis and survival in resected lung carcinoma based on the new international staging system. J Thorac Cardiovasc Surg 96: 440–447

    PubMed  CAS  Google Scholar 

  28. Naruke T, Goya T, Tsuchiya R, Suemasu K (1988) The importance of surgery to non-small cell carcinoma of lung with mediastinal lymph node metastasis. Ann Thorac Surg 46: 603–610

    Article  PubMed  CAS  Google Scholar 

  29. O’Connell JP, Kris MG, Gralla RJ, Groshen S, Trust A, Fiore JJ, Kelsen DP, Heelan RT, Golby RB (1986) Frequency and prognostic importance of pretreatment clinical characteristics in patients with advanced non-small-cell lung cancer treated with combination chemotherapy. J Clin Oncol 4: 1604–1614

    Google Scholar 

  30. Orr ST, Aisner J (1986) Performance status assessment among oncology patients: a review. Cancer Treat Rep 70: 1423–1429

    PubMed  CAS  Google Scholar 

  31. Osterlind K, Anderson PK (1986) Prognostic factors in small cell lung cancer: multivariate model based on 788 patients treated with chemotherapy with or without irradiation. Cancer Res 46: 4189–4194

    PubMed  CAS  Google Scholar 

  32. Quinlan DC, Davidson AG, Summers CL, Warden HE, Doshi HM (1992) Accumulation of p53 protein correlates with a poor prognosis in human lung cancer. Cancer Res 52: 4828–4831

    PubMed  CAS  Google Scholar 

  33. Rapp E, Pater JL, Willan A, Cormier Y, Murray N, Evans WK, Hodson DI, Clark DA, Feld R, Arnold AM, Ayoub JI, Wilson KS, Latreille J, Wierzbicki FR, Hill DP (1988) Chemotherapy can prolong survival in patients with advanced non-small-cell lung cancer. Report of a Canadian multicenter randomized trial. J Clin Oncol 6: 633–641

    Google Scholar 

  34. Sagman U, Maki E, Evans WK, Shepherd FA, Sculier JP, Haddad R, Payne D, Pringle JF, Yeoh JL, Ciampi A, DeBoer G, McKinney S, Ginsberg R, Feld R (1991). Small-cell carcinoma of the lung: derivation of a prognostic staging system. J Clin Oncol 9: 1639–1649

    PubMed  CAS  Google Scholar 

  35. Sakurai M, Shinkai T, Eguchi K, Sasaki Y, Tamura T, Miura K, Fujiwara Y, Otsu A, Horiuchi N, Nakano H, Nakagawa K, Hong WS, Saijo N (1987) Prognostic factors in non-small cell lung cancer: multiregression analysis in the National Cancer Center Hospital ( Japan ). J Cancer Res Clin Oncol 113: 563–566

    Google Scholar 

  36. Schmidt RA, Rusch VW, Piantadosi S (1992) A flow cytometric study of non-small cell lung cancer classified as T1N0. Cancer 69: 78–85

    Article  PubMed  CAS  Google Scholar 

  37. Shinkai T, Sakurai M, Eguchi K, Sasaki Y, Tamura T, Fujiwara Y, Fukuda M, Yamada K, Kojima A, Sasaki S, Soejima Y, Akiyama Y, Minato K, Nakagawa K, Ono R, Saijo N (1989) Prognostic factors in small cell lung cancer: multivariate analysis in the National Cancer Center Hospital ( Japan ). Jpn J Clin Oncol 19: 135–141

    Google Scholar 

  38. Shinkai T, Eguchi K, Sasaki Y, Tamura T, Ohe Y, Kojima A, Oshita F, Miya T, Okamoto H, Iemura K, Saijo N (1992) A prognostic-factor index in advanced non-small-cell lung cancer treated with cisplatin-containing combination chemotherapy. Cancer Chemother Pharmacol 30: 1–6

    Article  PubMed  CAS  Google Scholar 

  39. Simony J, Pujol JL, Radal M, Ursule E, Michel FB, Pujol H (1990) In situ evaluation of growth fraction determined by monoclonal antibody Ki-67 and ploidy in surgically resected non-small cell lung cancers. Cancer Res 50: 4382–4387

    PubMed  CAS  Google Scholar 

  40. Slebos RJC, Kibbelaar RD (1990) K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung. N Engl J Med 323: 561–565

    Article  PubMed  CAS  Google Scholar 

  41. Sorensen JB (1992) Prognosis and prognostic factors in adenocarcinoma of the lung. Dan Med Bull 39: 453–463

    PubMed  CAS  Google Scholar 

  42. Souhami RL, Bradbury I, Geddes DM, Spiro SG, Harper PG, Tobias JS (1985) Prognostic significance of laboratory parameters measured at diagnosis in small cell carcinoma of the lung. Cancer Res 45: 2878–2882

    PubMed  CAS  Google Scholar 

  43. Spiegelman D, Maurer LH, Ware JH, Perry MC, Chahinian AP, Comis R, Eaton W, Zimmer B, Green M (1989) Prognostic factors in small-cell carcinoma of the lung: an analysis of 1,521 patients. J Clin Oncol 7: 344–354

    PubMed  CAS  Google Scholar 

  44. Stanley K, Cox JD, Petrovich Z, Paig C (1981) Patterns of failure in patients with inoperable carcinoma of the lung. Cancer 47: 2725–2729

    Article  PubMed  CAS  Google Scholar 

  45. Sugio K, Ishida T, Yokoyama H, Inoue T, Sugimachi K, Sasazuki T (1992) ras gene mutation as a prognostic marker in adenocarcinoma of the human lung without lymph node metastasis. Cancer Res 52: 2903–2906

    Google Scholar 

  46. Van Bodegom PC, Baak JPA, Galen CSV, Schipper NW, Wisse-Brekelmans ECM, Vanderschueren RGJRA, Wagenaar SS (1989) The percentage of aneuploid cells is significantly correlated with survival in accurately staged patients with stage I resected squamous cell lung cancer and long-term follow up. Cancer 63: 143–147

    Article  PubMed  Google Scholar 

  47. Verger E, Salamero M, Conill C (1992) Can Karnofsky performance status be transformed to the Eastern Cooperative Oncology Group scoring scale and vice versa? Eur J Cancer 28A: 1328–1330

    Article  Google Scholar 

  48. Vincent MD, Ashley SE, Smith IE (1987) Prognostic factors in small cell lung cancer: a simple prognostic index is better than conventional staging. Eur J Cancer Clin Oncol 23: 1589–1599

    Article  PubMed  CAS  Google Scholar 

  49. Volm M, Efferth T, Mattern J (1992) Oncoprotein (c-myc, c-erbBl, c-ercB2, c-fos) and suppressor gene product (p53) expression in squamous cell carcinomas of the lung: clinical and biological correlations. Anticancer Res 12: 11–20

    PubMed  CAS  Google Scholar 

  50. Williams DE, Pairolero PC, Davis CS, Bernatz PE, Payne WS, Taylor WF, Uhlenhopp MA, Fontana RS (1981) Survival of patients surgically treated for stage I lung cancer. J Thorac Cardiovasc Surg 82: 70–76

    PubMed  CAS  Google Scholar 

  51. World Health Organization (1981) Histological typing of lung tumours, 2nd edn. World Health Organization, Geneva, pp. 1–41

    Google Scholar 

  52. Wojtukiewicz MZ, Zacharski LR, Moritz TE, Hur K, Edwards RL, Rickles FR (1992) Prognostic significance of blood coagulation tests in carcinoma of the lung and colon. Blood Coagul Fibrinolysis 3: 429–437

    PubMed  CAS  Google Scholar 

  53. Yoshida K, Morinaga S, Shimosato Y, Hayata Y (1989) A cell kinetic study of pulmonary adenocarcinoma by an immunoperoxidase procedure after bromodeoxyuridine labeling. Cancer 64: 2284–2291

    Article  PubMed  CAS  Google Scholar 

  54. Zubrod CG, Schneiderman M, Frei E et al (1960) Appraisal of methods for the study of chemotherapy of cancer in man: comparative therapeutic trial of nitrogen mustard and triethylene thiophosphoramide. J Chron Dis 11: 7–33

    Article  Google Scholar 

Download references

Authors
  1. H. Asamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Naruke
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Chirurgische Universitätsklinik Erlangen, Krankenhausstr. 12, 91054, Erlangen, Germany

    P. Hermanek (Vorstand der Abteilung für Klinische Pathologie i. R.) (Vorstand der Abteilung für Klinische Pathologie i. R.)

  2. Princess Margaret Hospital, Department of Radiation Oncology, University of Toronto, 500 Sherbourne Street, Toronto, Ontario, M4X 1K9, Canada

    Mary K. Gospodarowicz

  3. Early Detection Branch, Division of Cancer Prevention and Control, National Cancer Institute, EPN Building, Room 305 9000 Rockville Pike, Bethesda, MD, 20892, USA

    D. E. Henson

  4. University of Medicine and Dentistry, New Jersey Medical School, Newark, NJ, USA

    R. V. P. Hutter (Clinical Professor of Pathology) (Clinical Professor of Pathology)

  5. Department of Pathology, Saint Barnabas Medical Center, Old Short Hills Road, Livingston, NJ, 07039, USA

    R. V. P. Hutter (Clinical Professor of Pathology) (Clinical Professor of Pathology)

  6. Uniformed Services University of the Health Sciences, Bethesda, MD, USA

    L. H. Sobin (Professor of Pathology) (Professor of Pathology)

  7. Division of Gastrointestinal Pathology, Armed Forces Institute of Pathology, Washington, DC, 20306, USA

    L. H. Sobin (Professor of Pathology) (Professor of Pathology)

Rights and permissions

Reprints and permissions

Copyright information

© 1995 International Union Against Cancer, Geneva

About this chapter

Cite this chapter

Asamura, H., Naruke, T. (1995). Lung Carcinoma. In: Hermanek, P., Gospodarowicz, M.K., Henson, D.E., Hutter, R.V.P., Sobin, L.H. (eds) Prognostic Factors in Cancer. UICC International Union Against Cancer / Union Internationale Contre le Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79395-0_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-79395-0_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-58688-3

  • Online ISBN: 978-3-642-79395-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation