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Carcinoma of the Gallbladder

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Prognostic Factors in Cancer

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Abstract

Carcinoma of the gallbladder is an uncommon but highly lethal disease that often causes death in less than 1 year after diagnosis [2, 11]. In a collected series of more than 1700 patients, the 5-year survival rate after surgical resection was 2.6% [9]. At the Beth Israel Medical Center in New York, the 5-year survival rate was 11.3% [18]. In an analysis of 2354 cases from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute, the overall 5-year survival rate was 12.1% [7]. Because carcinomas of the gallbladder are relatively rare and known to have a poor outcome, investigators have not systematically evaluated new prognostic factors. In this report, we describe the prognostic factors for carcinomas of the gallbladder based on our analysis of published data. There has been no multivariate analysis reported on combinations of the different prognostic factors.

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References

  1. Albores-Saavedra J, Angeles-Angeles A, Manrique JJ, Henson DE (1984) Carcinoma in situ of the gallbladder: a clinico-pathologic study of 18 cases. Am J Surg Pathol 8: 323–333

    Article  PubMed  CAS  Google Scholar 

  2. Albores-Saavedra J, Henson DE (1986) Tumors of the gallbladder and extrahepatic bile ducts. Armed Forces Institute of Pathology, Washington DC

    Google Scholar 

  3. Albores-Saavedra J, Nadji M, Morales AR, Henson DE (1983) Carcinoembryonic antigen in normal, preneoplastic, and neoplastic gallbladder epithelium. Cancer 52: 1069–1072

    Article  PubMed  CAS  Google Scholar 

  4. Andrews W, Smith F (1987) Chemotherapy for cholangiocarcinoma and gallbladder cancer. In: Wanebo HJ (ed) Hepatic and biliary cancer. Dekker, New York, pp 453–457

    Google Scholar 

  5. Bergdahl L (1980) Gallbladder carcinoma first diagnosed at microscopic examination of gallbladders removed for presumed benign disease. Ann Surg 191: 19–22

    Article  PubMed  CAS  Google Scholar 

  6. Bosset JF, Mantion G, Gillet M et al. (1989) Primary carcinoma of the gallbladder: adjuvant postoperative external irradiation. Cancer 64: 1843–1847

    Article  PubMed  CAS  Google Scholar 

  7. Carriaga MT, Henson DE (1995) Liver, gallbladder, extrahepatic bile ducts, and pancreas: incidence and prognosis by histologic type. SEER population-based data, 1973–1987. Cancer (in press)

    Google Scholar 

  8. Donohue JH, Nagorney DM, Grant CS, Tsushima K, Ilstrup DM, Adson MA (1990) Carci-noma of the gallbladder: does radical surgery improve outcome? Arch Surg 125: 234–241

    Google Scholar 

  9. Dowdy GS Jr (1969) The biliary tract. Lea and Febiger, Philadelphia

    Google Scholar 

  10. Guo KJ, Yamaguchi K, Enjoji M (1988) Undifferentiated carcinoma of the gallbladder: a clinicopathologic, histochemical, and immunohistochemical study of 21 patients with a poor prognosis. Cancer 61: 1872–1879

    Article  PubMed  CAS  Google Scholar 

  11. Henson DE, Albores-Saavedra J, Corle D (1992) Carcinoma of the gallbladder: histologic types, stage of disease, grade, and survival rates. Cancer 70: 1493–1497

    Article  PubMed  CAS  Google Scholar 

  12. Hisatomi K, Haratake J, Horie A, Ohsato K (1990) Relation of histopathological features to prognosis of gallbladder cancer. Am J Gastroenterol 85: 567–572

    PubMed  CAS  Google Scholar 

  13. Houry S, Schlienger M, Huguier M, Lacaine F, Penne F, Laugier A (1989) Gallbladder carcinoma: role of radiation therapy. Br J Surg 76: 448–450

    Article  PubMed  CAS  Google Scholar 

  14. Hsu W, Deziel DJ, Gould VE, Warren WH, Gooch GT, Staren ED (1991) Neuroendocrine differentiation and prognosis of extrahepatic biliary tract carcinoma. Surgery 110: 604–610

    PubMed  CAS  Google Scholar 

  15. Johnson LA, Lavin PT, Dayal YY, Geller SA, Doos WG, Cooper HS, Gerber JE, Masse ST, Weiland LH, Moertel CG, Engstrom PS (1986) Gallbladder adenocarcinoma: prognostic significance of tumor acid mucopolysaccharide content. J Surg Oncol 33: 243–245

    Article  PubMed  CAS  Google Scholar 

  16. Johnson LA, Lavin PT, Yogeshwar YD, Geller SA et al (1987) Gallbladder adenocarcinoma: the prognostic signficance of histologic grade. J Surg Oncol 34: 16–18

    Article  PubMed  CAS  Google Scholar 

  17. Matsumoto Y, Fujii H, Aoyama H, Yamamoto M, Sugahara K, Suda K (1992) Surgical treatment of primary carcinoma of the gallbladder based on the histologic analysis of 48 surgical specimens. Am J Surg 163: 239–245

    Article  PubMed  CAS  Google Scholar 

  18. Nadler LH, McSherry CK (1992) Carcinoma of the gallbladder: review of the literature and report on 56 cases at the Beth Israel Medical Center. Mt Sinai J Med 59: 47–52

    PubMed  CAS  Google Scholar 

  19. Ouchi K, Owada Y, Matsumo S, Sato T (1987) Prognostic factors in the surgical treatment of gallbladder carcinoma. Surgery 101: 731–737

    PubMed  CAS  Google Scholar 

  20. Shirai Y, Yoshida K, Tsukada K, Muto Y (1992) Inapparent carcinoma of the gallbladder: an appraisal of a radical second operation after simple cholecystectomy. Ann Surg 215: 326–331

    Article  PubMed  CAS  Google Scholar 

  21. Strom BL, Iliopoulos D, Atkinson B, Herlyn M, West SL, Maislin G, Saul S, Varello MA, Rodriguez-Martinez HA, Rios-Dalenz J, Soloway RD (1989) Pathophysiology of tumor pro¬gression in human gallbladder: flow cytometry, CEA, and CA 19-9 levels in bile and serum in different stages of gallbladder disease. J Natl Cancer Inst 81: 1575–1580

    Article  PubMed  CAS  Google Scholar 

  22. Sumiyoshi K, Nagai E, Chijiwa K, Nakayama F (1992) Pathology of carcinoma of the gallbladder. World J Surg 15: 315–321

    Article  Google Scholar 

  23. Suzuki T, Takano Y, Kakita A, Okudaira M (1993) An immunohistochemical and molecular biological study of c-erb-B2 amplification and prognostic relevance in gallbladder cancer. Pathol Res Pract 189: 283–292

    PubMed  CAS  Google Scholar 

  24. Yamaguchi K, Enjoji M (1988) Carcinoma of the gallbladder: a clinicopathology of 103 patients and newly proposed staging. Cancer 62: 1425–1432

    Article  PubMed  CAS  Google Scholar 

  25. Yamamoto M, Makajo S, Tahara E (1989) Carcinoma of the gallbladder: the correlation between histogenesis and prognosis. Virchows Arch [A] 414: 83–90

    Article  CAS  Google Scholar 

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Authors
  1. M. T. Carriaga
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  2. D. E. Henson
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Editor information

Editors and Affiliations

  1. Chirurgische Universitätsklinik Erlangen, Krankenhausstr. 12, 91054, Erlangen, Germany

    P. Hermanek (Vorstand der Abteilung für Klinische Pathologie i. R.) (Vorstand der Abteilung für Klinische Pathologie i. R.)

  2. Princess Margaret Hospital, Department of Radiation Oncology, University of Toronto, 500 Sherbourne Street, Toronto, Ontario, M4X 1K9, Canada

    Mary K. Gospodarowicz

  3. Early Detection Branch, Division of Cancer Prevention and Control, National Cancer Institute, EPN Building, Room 305 9000 Rockville Pike, Bethesda, MD, 20892, USA

    D. E. Henson

  4. University of Medicine and Dentistry, New Jersey Medical School, Newark, NJ, USA

    R. V. P. Hutter (Clinical Professor of Pathology) (Clinical Professor of Pathology)

  5. Department of Pathology, Saint Barnabas Medical Center, Old Short Hills Road, Livingston, NJ, 07039, USA

    R. V. P. Hutter (Clinical Professor of Pathology) (Clinical Professor of Pathology)

  6. Uniformed Services University of the Health Sciences, Bethesda, MD, USA

    L. H. Sobin (Professor of Pathology) (Professor of Pathology)

  7. Division of Gastrointestinal Pathology, Armed Forces Institute of Pathology, Washington, DC, 20306, USA

    L. H. Sobin (Professor of Pathology) (Professor of Pathology)

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© 1995 International Union Against Cancer, Geneva

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Carriaga, M.T., Henson, D.E. (1995). Carcinoma of the Gallbladder. In: Hermanek, P., Gospodarowicz, M.K., Henson, D.E., Hutter, R.V.P., Sobin, L.H. (eds) Prognostic Factors in Cancer. UICC International Union Against Cancer / Union Internationale Contre le Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79395-0_10

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  • DOI: https://doi.org/10.1007/978-3-642-79395-0_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-58688-3

  • Online ISBN: 978-3-642-79395-0

  • eBook Packages: Springer Book Archive

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