Use of Fibrin Glue in Reconstructive Plastic Surgery
Human fibrin glue (Tissucol) is a plasma-derived compound endowed with adhesive and hemostatic properties and possessing a specific local anti-infection function mediated through activation of nonspecific immune elements. The aim of this randomized clinical study was to show that in patients who have undergone prolonged reconstructive plastic interventions after ablative cancer surgery following cancer resection, Tissucol decreases infectious complications. Between June 1985 and February 1992, 102 subjects were treated with fibrin glue during reconstruction operations. Analysis of the results showed that in the Tissucol group a statistically significant reduction was verified regarding both immediate complications, such as partial separation of the surgical wound and inflammation, and delayed complications, such as cicatricial hyperthrophy. In conclusion, patients treated with Tissucol showed a better quality of surgical wound, a more rapid postoperative functional recovery and, consequently, a decrease in the duration of hospitalization as compared to a control group of 112 patients.
KeywordsFibrin Glue Surgical Wound Factor Xiii Fibrin Sealant Myocutaneous Flap
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