Use of Fibrin Glue in Reconstructive Plastic Surgery

  • T. Fabrizio
  • M. Nava
  • N. Arioli
  • L. Calabrese
  • O. Parise
  • R. Molinari
  • A. Savani
Conference paper


Human fibrin glue (Tissucol) is a plasma-derived compound endowed with adhesive and hemostatic properties and possessing a specific local anti-infection function mediated through activation of nonspecific immune elements. The aim of this randomized clinical study was to show that in patients who have undergone prolonged reconstructive plastic interventions after ablative cancer surgery following cancer resection, Tissucol decreases infectious complications. Between June 1985 and February 1992, 102 subjects were treated with fibrin glue during reconstruction operations. Analysis of the results showed that in the Tissucol group a statistically significant reduction was verified regarding both immediate complications, such as partial separation of the surgical wound and inflammation, and delayed complications, such as cicatricial hyperthrophy. In conclusion, patients treated with Tissucol showed a better quality of surgical wound, a more rapid postoperative functional recovery and, consequently, a decrease in the duration of hospitalization as compared to a control group of 112 patients.


Fibrin Glue Surgical Wound Factor Xiii Fibrin Sealant Myocutaneous Flap 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Spängler HP (1976) Tissue adhesion and local hemostasis fibrinogen, thrombin and clotting factor XIII (experimental investigation-clinical experience). Wien Klin Wochenschr 88 [Suppl 49]: 3Google Scholar
  2. 2.
    Staindl O (1982) The fibrin-adhesive system in plastic surgery of head and neck. J Head Neck Pathol 3: 78Google Scholar
  3. 3.
    Staindl O (1979) The healing of wounds and scar formation under the influence of a tissue adhesion system with fibrinogen, thrombin and coagulation factor XIII. Arch Otorhinolaryngol 222: 241PubMedCrossRefGoogle Scholar
  4. 4.
    Brandstedt S, Rank F, Olson PS (1980) Wound healing and formation of granulation tissue in normal and defibrinogenated rabbits. An experimental model and histological study. Eur Surg Res 12: 12Google Scholar
  5. 5.
    Hedelin H, Lundholm K, Teger-Nilsson AC et al. (1983) Influence of local fibrin deposition on granulation tissue formation. A biochemical study in the rat. Eur Surg Res 15: 312PubMedCrossRefGoogle Scholar
  6. 6.
    Hunt TK, Knighton DR, Thakral KK et al. (1984) Studies on inflammation and wound healing: angiogenesis and collagen synthesis stimulated in vivo by resident and activated wound macrophages. Surgery 86: 48Google Scholar
  7. 7.
    Kasai S, Kunimoto R, Nitta K (1983) Cross-linking of fibrin by activated factor XIII stimulates attachment, morphological changes and proliferation of fibroblast. Biomed Res 4: 155Google Scholar
  8. 8.
    Donati L (1986) Indicazioni e limiti della colla di fibrina (Tissucol) in chirurgia plastica. Proceedings of the XXXVth Conference of the Italian Society of Plastic Surgery, Milan, Sept 25–27, 1986Google Scholar
  9. 9.
    Germani G (1982) Utilizzazione della colla di fibrina in chirurgia plastica. Riv Ital Chir Plast 1: 443Google Scholar
  10. 10.
    Bosh P (1980) Experimental investigation of the effect of fibrin adhesive graft. Arch Orthop Trauma Surg 96: 177CrossRefGoogle Scholar
  11. 11.
    Cronkite EP, Lozner EL, Deaver JM (1944) Use of thrombin and fibrinogen in skin grafting. J Am Med Assoc 124: 976CrossRefGoogle Scholar
  12. 12.
    Matras H (1982) The use of fibrin sealant in oral and maxillo-facial surgery. J Oral Maxillofac Surg 40: 617PubMedCrossRefGoogle Scholar
  13. 13.
    Aach RD, Szmuness W, Mosley JW et al. (1981) Serum alanine aminotransferase of donors in relation to the risk of non-A, non-B hepatitis in recipients. N Engl J Med 304: 989PubMedCrossRefGoogle Scholar
  14. 14.
    Hornbrook MC, Dood RY, Jacobs P et al. (1982) Reducing the incidence of non-A, non-B post-transfusion hepatitis by testing donor blood for alanine aminotransferase. N Engl J Med 307: 1315PubMedCrossRefGoogle Scholar
  15. 15.
    Eder G, Neumann M, Cerwenka R, Baumgarten K (1986) Preliminary results of a randomized controlled study on the risk of hepatitis transmission of a two-component fibrin sealant in operative medicine. In: Schlag G, Redi H (eds) Trau-matology-orthopaedics. Springer, Berlin Heidelberg New York, p 51 (Fibrin seal-ants in operative medicine, vol 7 )Google Scholar
  16. 16.
    Rousou J, Gonzales-Lavin J, Cosgrove D et al. (1989) Randomized clinical trial of fibrin sealant in patients undergoing resternotomy or reoperation after cardiac operations. JThorac Cardiovasc Surg 97: 194Google Scholar
  17. 17.
    Schricker KT, Scheele J (1981) Hepatitisrisiko der Fibrinklebung in der Allgemein- chirurgie. Med Welt 32: 783PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • T. Fabrizio
  • M. Nava
  • N. Arioli
  • L. Calabrese
  • O. Parise
  • R. Molinari
  • A. Savani

There are no affiliations available

Personalised recommendations