Abstract
Endotoxin released on lysis of gram-negative bacteria contains a macromolecular glycolipid termed lipopolysaccharide (LPS) which is able to reproduce many of the cardiovascular features of septic shock (Parratt 1989). The persistent loss of vascular tone observed during gram-negative septicemia and after injection of LPS in animals and in humans is often unresponsive to catecholamines and other vasoconstrictor agents and is associated with a high mortality rate (Groeneveld et al. 1986).
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Stoclet, J.C., Schott, C.A., Schneider, F., Berton, C., Paya, D. (1995). Induction by Endotoxin of Nitric Oxide Production in Vascular Smooth Muscle Cells. In: Schlag, G., Redl, H. (eds) Shock, Sepsis, and Organ Failure — Nitric Oxide. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79343-1_5
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DOI: https://doi.org/10.1007/978-3-642-79343-1_5
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