Induction by Endotoxin of Nitric Oxide Production in Vascular Smooth Muscle Cells

  • J. C. Stoclet
  • C. A. Schott
  • F. Schneider
  • C. Berton
  • D. Paya

Abstract

Endotoxin released on lysis of gram-negative bacteria contains a macromolecular glycolipid termed lipopolysaccharide (LPS) which is able to reproduce many of the cardiovascular features of septic shock (Parratt 1989). The persistent loss of vascular tone observed during gram-negative septicemia and after injection of LPS in animals and in humans is often unresponsive to catecholamines and other vasoconstrictor agents and is associated with a high mortality rate (Groeneveld et al. 1986).

Keywords

Nitrite Arginine Dexamethasone Methotrexate Glucocorticoid 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • J. C. Stoclet
  • C. A. Schott
  • F. Schneider
  • C. Berton
  • D. Paya

There are no affiliations available

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