Vasodilators in Sepsis

  • M. Booke
  • L. D. Traber
  • D. L. Traber
Conference paper


Sepsis is defined as the systemic inflammatory response to infection [1]. Originally it was believed that sepsis occurs as the result of released lipopolysaccharide (endotoxin) by gram-negative bacteria. However, exotoxin of gram-positive bacteria as well as viral and fungal products produce the same clinical picture [2]. Because noninfectious diseases can cause the same inflammatory response seen in infectious sepsis, Bone et al. proposed the term systemic inflammatory response syndrome to describe this inflammatory process independent of its cause [3]. In fact, in his study only 45% of septic patients had a positive blood culture [4], and only 24.6% of the septic patients had gram-negative infection [5]. Sepsis, or systemic inflammatory response syndrome, is an increasingly common cause of morbidity and mortality especially in elderly, immunocompromised, and critically ill patients [5, 6]. Sepsis is the most common cause of death in nonsurgical intensive care units [7]. Advances in the treatment of sepsis are therefore desperately needed.


Nitric Oxide Nitric Oxide Mean Arterial Pressure Atrial Natriuretic Peptide Septic Patient 
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© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • M. Booke
  • L. D. Traber
  • D. L. Traber

There are no affiliations available

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