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Clinical Relevance of Atrial Natriuretic Peptide

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Experimental Hypertension and Therapeutic Progress: Vasodilation and Beyond

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Abstract

The major focus of interest in the endocrine control of sodium and water balance was until recently the anti-natriuretic renin-angiotensin-aldosterone system (RAAS). After 25 years of indirect evidence for an endocrine role for the heart, de Bold found that injection of atrial but not ventricular myocardial extracts of rat heart caused striking increases in urinary sodium, chloride and water excretion, an increase in haematocrit and a decrease in systemic blood pressure when injected into rats of the same strain, suggesting the presence of a potent natriuretic and vasoactive hormone in the atria of the heart [1]. Within 2 years, details of the structure of a major component of the atrial granules were first reported, and by 1984 groups in Japan and in North America had independently sequenced and synthesized both a prohormone and major active constituent of atrial myocyte dense granules [2–6] called atrial natriuretic peptide, polypeptide (ANP) or factor (ANF).

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Authors and Affiliations

  1. Blood Pressure Unit, Department of Physiological Medicine, St George’s Hospital Medical School, Cranmer Terrace, London, SW 17 ORE, UK

    Donald R. J. Singer

  2. Heart Sciences Centre, Harefield Hospital, Harefield, Middlesex, United Kingdom

    Donald R. J. Singer

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  1. Donald R. J. Singer
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Editors and Affiliations

  1. Cardiovascular and Arteriosclerosis Research, Bayer AG, Aprather Weg 18a, 42096, Wuppertal, Germany

    Bernward Garthoff DVM  & Andreas M. Knorr Ph.D.  & 

  2. International Research Pharma, Bayer AG, Aprather Weg 18a, 42096, Wuppertal, Germany

    Wolf-Dieter Busse Ph.D. (Professor) (Professor)

  3. Coordination International Research, Bayer AG, Aprather Weg 18a, 42096, Wuppertal, Germany

    Friedel Seuter Ph.D.

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© 1995 Springer-Verlag Berlin Heidelberg

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Singer, D.R.J. (1995). Clinical Relevance of Atrial Natriuretic Peptide. In: Garthoff, B., Knorr, A.M., Busse, WD., Seuter, F. (eds) Experimental Hypertension and Therapeutic Progress: Vasodilation and Beyond. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79338-7_9

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  • DOI: https://doi.org/10.1007/978-3-642-79338-7_9

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