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Klinische Histokompatibilitätsbestimmung

  • Rudolf Peter Wüthrich

Zusammenfassung

Die Rolle der klinischen Histokompatibilitätsbestimmung liegt im wesentlichen darin, die Gewebeverträglichkeit der Spenderniere beim Transplantierten zu gewährleisten. Die Kompatibilität wird durch möglichst gute HLA-Übereinstimmung und durch Abwesenheit von präformierten HLA-Antikörpern gesichert (5, 6, 18). Die HLA-Antigene sind neben dem ABO-Blutgruppensystem die hauptsächlichsten Gewebeverträglichkeitsantigene und stellen die primären Angriffsstellen der Abstoßungsreaktion dar. HLA-Antigene verleihen biologische Individualität und erlauben dem Immunsystem, zwischen Eigen und Fremd zu unterscheiden. Sie funktionieren auch als Kontrollelemente bei der Immunerkennung und bei der Regulation der Immunreaktion (3).

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Rudolf Peter Wüthrich
    • 1
  1. 1.Departement für innere Medizin Abt. für NephrologieUniversitätsspital ZürichZürichSwitzerland

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