Skip to main content
SpringerLink
Log in
Book cover

Nierentransplantation pp 51–61Cite as

Klinische Histokompatibilitätsbestimmung

  • Chapter

  • 31 Accesses

Zusammenfassung

Die Rolle der klinischen Histokompatibilitätsbestimmung liegt im wesentlichen darin, die Gewebeverträglichkeit der Spenderniere beim Transplantierten zu gewährleisten. Die Kompatibilität wird durch möglichst gute HLA-Übereinstimmung und durch Abwesenheit von präformierten HLA-Antikörpern gesichert (5, 6, 18). Die HLA-Antigene sind neben dem ABO-Blutgruppensystem die hauptsächlichsten Gewebeverträglichkeitsantigene und stellen die primären Angriffsstellen der Abstoßungsreaktion dar. HLA-Antigene verleihen biologische Individualität und erlauben dem Immunsystem, zwischen Eigen und Fremd zu unterscheiden. Sie funktionieren auch als Kontrollelemente bei der Immunerkennung und bei der Regulation der Immunreaktion (3).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Albert ED, Baur MP, Mayr WR (eds) (1984) Histocompatibility Testing 1984. Report of the 9th International Histocompatibility Workshop and Conference. Springer, Berlin

    Google Scholar 

  2. Boyum A (1968) Separation of leukocytes from blood and bone marrow. Scand J Clin Lab Invest 21: S97

    Google Scholar 

  3. Braun WE (1986) Histocompatibility testing. In: Garovoy MR, Guttmann RD (eds). Renal transplantation, chap 2. Churchill-Livingstone, New York, pp 15–48

    Google Scholar 

  4. Brynger H, Rydberg L, Samuelsson B, Blohme I, Lindholm A, Sandberg L (1982) Renal transplantation across a blood group barrier - A2 kidneys into 0 recipients. Proc EDTA 19: 427

    Google Scholar 

  5. Cecka JM, Terasaki PI (1988) Tissue typing and histocompatibility. In: Toledo-Pereyra LH (ed) Kidney transplantation, chap 1. Davis, Philadelphia, pp 3–16

    Google Scholar 

  6. Chapman JR (1993) The sensitized patient. In: Thomson AW, Catto GRD (eds) Immunology of renal transplantation, chap 14. Edward Arnold, London, pp 235–254

    Google Scholar 

  7. Colombe BW, Garovoy MR (1989) Clinical histocompatibility testing. In: Milford EL, Brenner BM, Stein JH (eds) Renal transplantation. Contemporary issues in nephrology, vol 19, chap 2. Churchill-Livingstone, New York, pp 21–43

    Google Scholar 

  8. Garovoy MR, Franco V, Zschaeck D, Carpenter CB, Strom TB, Merrill JP (1973) Direct lymphocyte-mediated cytotoxicity as an assay of presensitisation. Lancet 1: 573

    Article  PubMed  CAS  Google Scholar 

  9. Grimm PC, Sinai-Trieman L, Sekiya NM, Robertson LS, Robinson BJ, Fine RN, Ettenger RB (1990) Effects of recombinant human erythropoietin on HLA sensitization and cell mediated immunity. Kindey Int 38: 12

    Article  CAS  Google Scholar 

  10. Grumet FC, Fendly BM, Engleman EG (1981) Monoclonal anti-HLA-B27 antibody (B27M): Production and lack of detectable typing difference between patients with ankylosing spondylitis, Reiter’s syndrome, and normal controls. Lancet 2: 174

    Google Scholar 

  11. Hakim RM, Milford E, Himmelfarb J, Wingard R, Lazarus JM, Watt RM (1990) Extracorporeal removal of anti-HLA antibodies in transplant candidates. Am J Kidney Dis 16: 423

    PubMed  CAS  Google Scholar 

  12. Iwaki Y et al. (1987) Flow cytometry crossmatching in human cadaver kidney transplantation. Transplant Proc 19 (1): 764

    PubMed  CAS  Google Scholar 

  13. Kissmeyer-Nielsen F, Olsen S, Petersen VP, Fjeldborg O (1966) Hyperacute rejection of kidney allografts, associated with preexisting humoral antibodies against donor cells. Lancet 2: 662

    Article  PubMed  CAS  Google Scholar 

  14. Opelz G, Graver B, Mickey MR, Terasaki PI (1981) Lymphocytotoxic antibody responses to transfusions in potential kidney transplant recipients. Transplantation 32: 177

    Article  PubMed  CAS  Google Scholar 

  15. Patel R, Terasaki PI (1969) Significance of the positive crossmatch test in kidney transplantation. New Engl J Med 280: 735

    Article  PubMed  CAS  Google Scholar 

  16. Schwartz BD (1987) The human major histocompatibility HLA complex. In: Stites DP, Stobo JD, Wells JV (eds) Basic and clinical immunology, chap 6. Appleton and Lange, Norwalk CT, pp 50–64

    Google Scholar 

  17. Terasaki PI, Bernoco D, Park MS, Ozturk G, Iwaki Y (1978) Microdroplet testing for HLA-A, -B, -C and -D antigens. Am J Clin Pathol 69: 103

    PubMed  CAS  Google Scholar 

  18. Terasaki PI, McClelland JD (1964) Microdroplet assay of human serum cytotoxins. Nature 204: 998

    Article  PubMed  CAS  Google Scholar 

  19. Ting A (1988) HLA matching and crossmatching in renal transplantation. In: Morris PJ (ed) Kidney transplantation, 3rd edn, chap 8. Saunders, Philadelphia, pp 183–213

    Google Scholar 

  20. Ting A (1989) The highly sensitized patient. In: Catto GRD (ed) Transplantation. New clinical applications in nephrology, chap 2. Kluwer Academic Publishers, Dordrecht, The Netherlands, pp 39–57

    Google Scholar 

  21. Williams GM, Hume DM, Hudson RP, Morris PJ, Kano K, Milgrom F (1968) Hyperacute renal homograft rejection in man. New Engl J Med 279: 611

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departement für innere Medizin Abt. für Nephrologie, Universitätsspital Zürich, Rämistraße 100, CH-8091, Zürich, Switzerland

    PD Dr. med. Rudolf Peter Wüthrich

Authors
  1. PD Dr. med. Rudolf Peter Wüthrich
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Wüthrich, R.P. (1995). Klinische Histokompatibilitätsbestimmung. In: Nierentransplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79314-1_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-79314-1_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79315-8

  • Online ISBN: 978-3-642-79314-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation