Duodenal Mucosal Bicarbonate Secretion in Humans

  • Jon I. Isenberg
  • Daniel L. Hogan
Conference paper
Part of the NATO ASI Series book series (NATO ASI, volume 89)

Abstract

The old adage “Why doesn’t the stomach digest itself?” has intrigued physiologists, clinical investigators and physicians for generations. In humans, pure parietal cell secretion is approximately 160 mm, and while it is bufferred within the lumen the gastric and duodenal mucosa are subjected to a continual exposure of high concentrations of acid and pepsin. The ability of the gastroduodenal mucosa to protect itself from acid-peptic injury, as well as damage induced by drugs, other injurious agents, alcohol, ischemia, etc., involve a number of intrinsic pre-epithelial, epithelial and sub-epithelial defensive factors that work in concert to prevent mucosal injury. Indeed, when the aggressive factors overwhelm mucosal defense the result is inflammation, erosion or ulceration with the potential of their inherent complications. A host of defensive factors are under investigation including: mucus and bicarbonate secretion, surface active phospholipids, the “mucoid cap”, cellular resistance, acid/base transporters, growth factors, cytokines, leukocyte adhesion molecules and reconstitution.

Keywords

Ischemia Aspirin Morphine Adenosine Histamine 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Jon I. Isenberg
    • 1
  • Daniel L. Hogan
    • 1
  1. 1.Division of Gastroenterology Department of MedicineUniversity of California Medical CenterSan DiegoUSA

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