Advertisement

The Topology of the α, β Subunits of the Gastric H/K ATPase

  • Jai Moo Shin
  • Krister Bamberg
  • Marie Besancon
  • Keith Munson
  • Frederic Mercier
  • Dennis Bayle
  • Steve Hersey
  • George Sachs
Conference paper
Part of the NATO ASI Series book series (NATO ASI, volume 89)

Abstract

Knowledge of the secondary structure of the gastric H/K ATPase,a P type transport ATPase, allows deductions as to the ion transport pathway across the membrane spanning domain of the large, 1033 amino acid catalytic a subunit and as to the site of interaction between the smaller, glycosylated, ß subunit and the or subunit. The structure of this region of the enzyme also allows us to understand the molecular basis for inhibition of acid secretion by acid pump inhibitors, such as the substituted benzimidazoles and the K+ competitive type of H/K ATPase inhibitor.

Keywords

Membrane Anchor Membrane Span Domain Membrane Span Membrane Segment Hydropathy Plot 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Shull, G.E. and Lingrel, J.B. (1986) J. Biol. Chem., 261, 16788–16791.PubMedGoogle Scholar
  2. 2.
    Maeda,M., Ishizaki,J., and Futai,M. (1988) Biochem. Biophys. Res. Commun., 157, 203–209.CrossRefPubMedGoogle Scholar
  3. 3.
    Bamberg,K., Mercier,F., Reuben,M.A., Kobayashi,Y., Munson,K.B., and Sachs,G. (1992) Biochim. Biophys. Acta, 1131, 68–77CrossRefGoogle Scholar
  4. 4.
    Reuben, M.A., Lasater, L.S. and Sachs, G. (1990) Proc. Natl. Acad. Sci. U.S.A., 87, 6767–6771CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Toh, B.-H., Gleeson, P. A., Simpson, R. J., Moritz, R.L., Callaghan, J.M., GoIdkorn,I., Jones, C.M., Martinelli, T.M., Mu,F.-T., Humphris, D.C., Pettitt, J.M., Mori, Y., Masuda, T., Sobieszczuk, P., Weinstock, J., Mantamadiotis, T., and Baldwin, G.S. (1990) Proc. Natl. Acad. Sci. U.S.A., 87, 6418–6422.Google Scholar
  6. 6.
    Newman PR; Shull GE. (1991) Genomics, 11 (2), 252–62.CrossRefPubMedGoogle Scholar
  7. 7.
    Kyte, J. and Doolittle, R.F. (1982) J. Mol. Biol., 157, 105–132.CrossRefPubMedGoogle Scholar
  8. 8.
    Mercier, F., Reggio, H., Devilliers, G., Bataille, D., and Mangeat, P. (1989) J. Cell Biol., 108, 441–453.CrossRefPubMedGoogle Scholar
  9. 9.
    Besancon, M., Shin, J. M., Mercier F., Munson, K., Miller, M., Hersey, S., and Sachs, G. (1993) Biochemistry 32, 2345–2355CrossRefPubMedGoogle Scholar
  10. 10.
    Mendlein, J. and Sachs, G. (1990) J. Biol. Chem., 265, 5030–5036.PubMedGoogle Scholar
  11. 11.
    Munson, K.B. and Sachs,G. (1988) Biochemistry, 27, 3932–3938.CrossRefPubMedGoogle Scholar
  12. 12.
    Munson, K.B., Gutierrez, C., Balaji, V.N., Ramnarayan, K., and Sachs, G. (1991) J. Biol. Chem., 266, 18976–18988.PubMedGoogle Scholar
  13. 13.
    Price, E.M., Rice, D.A., and Lingrel, J.B. (1990) J. Biol. Chem., 265, 6638–6641.PubMedGoogle Scholar
  14. 14.
    Rabon, E., Sachs, G., Bassilian, S., Leach, C., and Keeling, D. (1991) J. Biol. Chem., 266, 12395–12401.PubMedGoogle Scholar
  15. 15.
    Fellenius, E., Berglindh, T., Sachs, G., Olbe,L., Elander, B., Sjostrand, S-E., and Wallmark, B. (1981) Nature, 290, 159–161.Google Scholar
  16. 16.
    Fellenius E. Personal CommunicationGoogle Scholar
  17. 17.
    Lorentzon, P., Jackson, R., Wallmark, B., and Sachs, G. (1987) Biochim. Biophys. Acta, 897, 41–51.CrossRefPubMedGoogle Scholar
  18. 18.
    Lindberg, P., Nordberg, P., Aiminger, T., Brandstrom, A. and Wallmark, B. (1986) J. Med. Chem., 29, 1327–1329.CrossRefPubMedGoogle Scholar
  19. 19.
    Wallmark, B., Brandstrom, A. and Lassen, H. (1984) Biochim. Biophys. Acta, 778, 549–558.CrossRefPubMedGoogle Scholar
  20. 20.
    Keeling, D.J., Fallowfield, C., and Underwood, A.H. (1987) Biochem. Pharmacol. 36, 339–344.CrossRefPubMedGoogle Scholar
  21. 21.
    Lorentzon, P., Eklundh, B., Brandstrom, A. and WalImark, B. (1985) Biochim. Biophys. Acta, 817, 25–32.CrossRefPubMedGoogle Scholar
  22. 22.
    Sachs, G., Shin, J.M., Besancon, M., and Prinz, C. (1993) Alimentary Pharmacology and Therapeutics, 7, 4–12.Google Scholar
  23. 23.
    Shin, J.M., Besancon, M., Simon, A., and Sachs, G. (1993) Biochim. Biophys. Acta, 1148 (2), 223–33.CrossRefPubMedGoogle Scholar
  24. 24.
    Scott, D.R., Munson, K., Modyanov, N., and Sachs, G. (1992) Biochim. Biophys. Acta,, 1112 (2), 246–50.CrossRefPubMedGoogle Scholar
  25. 25.
    Mercier, F., Bayle, D., Besancon, M., Joys, T., Shin, J.M., Lewin, M.J.M., Prinz, C., Reuben, A.M., Soumarmon, A., Wong, H., Walsh, J.H., and Sachs, G. (1993) Biochim. Biophys. Acta, 1149, 151–165CrossRefPubMedGoogle Scholar
  26. 26.
    Bayle, D., Benkouka, F., Robert, J.C., Peranzi, G., and Soumarmon, A. (1991) Comp. Biochem. Biophys. 101B, 519–525.Google Scholar
  27. 27.
    Bayle, D., Robert, J.C., Bamberg, K., Benkouka, F., Cheret, A.M., Lewin, M.J.M., Sachs, G., and Soumarmon, A. (1992) J. Biol. Chem., 267, 19060–19065.PubMedGoogle Scholar
  28. 28.
    Treuheit,M.J., Costello,C.E., and Kirley,T.L. (1993) J. Biol. Chem., 268, 13914–13919.PubMedGoogle Scholar
  29. 29.
    Chow, D.C., Cathy, M. B., and Forte, J. G. (1992) Am. J. Physiol. 263, C39–C46.PubMedGoogle Scholar
  30. 30.
    Rabon, E.C., Bassilian, S., and Jakobsen, L.J. (1990) Biochim. Biophys.Acta, 1039, 277–289.CrossRefPubMedGoogle Scholar
  31. 31.
    Okamoto, C.T., Karpilow, J.M., Smolka, A., and Forte, J.G. (1990) Biochim. Biophys. Acta. 1037, 360–372CrossRefPubMedGoogle Scholar
  32. 32.
    Shin, J.M. and Sachs, G. (1993) J. Biol. Chem., submitted.Google Scholar
  33. 33.
    Toyoshima, C., Sasabe, H., and Stokes, D.L. Nature, 362, 469–471.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Jai Moo Shin
    • 1
  • Krister Bamberg
    • 1
  • Marie Besancon
    • 1
  • Keith Munson
    • 1
  • Frederic Mercier
    • 1
  • Dennis Bayle
    • 1
  • Steve Hersey
    • 2
  • George Sachs
    • 1
  1. 1.UCLA and Wadsworth VAMCLos AngelesUSA
  2. 2.Emory UniversityAtlantaUSA

Personalised recommendations