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The Receptors Regulating Acid Secretion on and off the Parietal Cell

  • K. C. Kent Lloyd
  • Andrew H. Soll
Conference paper
Part of the NATO ASI Series book series (NATO ASI, volume 89)

Summary

Using a combination of in vitro and in vivo experimental techniques has made possible the identification of receptors that regulate gastric acid secretion by the parietal cell. Some of the newest discoveries in the area of regulation of acid secretion are related to the cellular localization of physiologically relevant receptors for acid secretagogues and acid inhibitors. In vitro techniques have enabled the ability to isolate, culture, and study the function of parietal cells, gastrin-containing “G” cells, histamine-containing ECL cells and somatostatin-containing “D” cells, and the ability to clone genes encoding for specific receptors. In vivo techniques have enabled the testing of hypotheses generated in a physiological model from what we learn from in vitro studies. This experimental strategy has greatly enhanced our understanding of the physiological role and the regulation of parietal cell secretion by secretagogues and inhibitors produced by various cell types within the gastric mucosa.

Keywords

Acid Secretion Histamine Release Parietal Cell Physiol Gastrointest Liver Gastrin Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Chuang C-N, Tanner M, Chen MCY, Davidson S, Soll AH (1992) Gastrin induction of histamine release from primary cultures of canine oxyntic mucosal cells. Am J Physiol Gastrointest Liver Physiol 263: G460–G465.Google Scholar
  2. Gerber JG, Barnes JS (1987) Histamine release in vivo by pentagastrin from the canine stomach. Journal of Pharmacology & Experimental Therapeutics 243: 887–892.Google Scholar
  3. Kopin AS, Lee Y-M, McBride EW, et al (1992) Expression cloning and characterization of the canine parietal cell gastrin receptor. Proc Natl Acad Sci USA 89: 3605–3609.CrossRefPubMedPubMedCentralGoogle Scholar
  4. Lloyd KCK, Maxwell V, Kovacs TOG, Miller J, Walsh JH (1992) Cholecystokinin receptor antagonist MK-329 blocks intestinal fat-induced inhibition of meal-stimulated gastric acid secretion. Gastroenterology 102: 131–138.CrossRefPubMedGoogle Scholar
  5. Mezey E, Palkovits M (1992) Localization of targets for anti-ulcer drugs in cells of the immune system. Science 258: 1662–1665.CrossRefPubMedGoogle Scholar
  6. Sandvik AK, Waldum HL, Kleveland PM, Schulzesognen B (1987) Gastrin produces an immediate and dose-dependent histamine release preceding acid secretion in the totally isolated, vascularly perfused rat stomach. Scand J Gastroenterol 22: 803–808.CrossRefPubMedGoogle Scholar
  7. Soll AH, Yamada T, Park J, Thomas LP (1984) Release of somatostatin-like immunoreactivity from canine fundic mucosal cells in primary culture. Am J Physiol Gastrointest Liver Physiol 247: G558–G566.Google Scholar
  8. Soll AH, Amirian DA, Park J, Elashoff JD, Yamada T (1985) Cholecystokinin potently releases somatostatin from canine fundic mucosal cells in short-term culture. Am J Physiol Gastrointest Liver Physiol 248: G569–G573.Google Scholar
  9. Wong HC, Walsh JH, Yang H, Taché Y, Buchan AM (1990) A monoclonal antibody to somatostatin with potent in vivo immunoneutralizing activity. Peptides 11: 707–712.CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • K. C. Kent Lloyd
    • 1
  • Andrew H. Soll
    • 1
  1. 1.CURE/UCLA Digestive Disease Core CenterUniversity of California, Los Angeles, Department of Veterans Affairs, VA Medical CenterWest Los AngelesUSA

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