The Receptors Regulating Acid Secretion on and off the Parietal Cell

  • K. C. Kent Lloyd
  • Andrew H. Soll
Conference paper
Part of the NATO ASI Series book series (NATO ASI, volume 89)


Using a combination of in vitro and in vivo experimental techniques has made possible the identification of receptors that regulate gastric acid secretion by the parietal cell. Some of the newest discoveries in the area of regulation of acid secretion are related to the cellular localization of physiologically relevant receptors for acid secretagogues and acid inhibitors. In vitro techniques have enabled the ability to isolate, culture, and study the function of parietal cells, gastrin-containing “G” cells, histamine-containing ECL cells and somatostatin-containing “D” cells, and the ability to clone genes encoding for specific receptors. In vivo techniques have enabled the testing of hypotheses generated in a physiological model from what we learn from in vitro studies. This experimental strategy has greatly enhanced our understanding of the physiological role and the regulation of parietal cell secretion by secretagogues and inhibitors produced by various cell types within the gastric mucosa.


Acid Secretion Histamine Release Parietal Cell Physiol Gastrointest Liver Gastrin Receptor 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • K. C. Kent Lloyd
    • 1
  • Andrew H. Soll
    • 1
  1. 1.CURE/UCLA Digestive Disease Core CenterUniversity of California, Los Angeles, Department of Veterans Affairs, VA Medical CenterWest Los AngelesUSA

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