The Receptors Regulating Acid Secretion on and off the Parietal Cell
Using a combination of in vitro and in vivo experimental techniques has made possible the identification of receptors that regulate gastric acid secretion by the parietal cell. Some of the newest discoveries in the area of regulation of acid secretion are related to the cellular localization of physiologically relevant receptors for acid secretagogues and acid inhibitors. In vitro techniques have enabled the ability to isolate, culture, and study the function of parietal cells, gastrin-containing “G” cells, histamine-containing ECL cells and somatostatin-containing “D” cells, and the ability to clone genes encoding for specific receptors. In vivo techniques have enabled the testing of hypotheses generated in a physiological model from what we learn from in vitro studies. This experimental strategy has greatly enhanced our understanding of the physiological role and the regulation of parietal cell secretion by secretagogues and inhibitors produced by various cell types within the gastric mucosa.
KeywordsPolypeptide Histamine Acetylcholine Atropine Mast
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