CFTR Chloride Channels and Pancreatic Ductal Bicarbonate Secretion

  • Barry E. Argent
  • John P. Winpenny
  • Michael A. Gray
Conference paper
Part of the NATO ASI Series book series (NATO ASI, volume 89)


The main function of pancreatic duct cells is to secrete a HC03--rich isotonic fluid (Fig. 1). This secretion flushes digestive enzymes, secreted by acinar cells located at the termini of the smallest ducts, along the ductal tree and into the duodenum (Fig. 1). It also neutralises acid chyme entering the duodenum from the stomach and thus helps to create the correct luminal environment for the digestion of food in the gut (Case amp; Argent, 1993: Argent amp; Case, 1994).


Cystic Fibrosis Cystic Fibrosis Transmembrane Conductance Regulator Duct Cell Chloride Channel Apical Plasma Membrane 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Barry E. Argent
    • 1
  • John P. Winpenny
    • 1
  • Michael A. Gray
    • 1
  1. 1.Department of Physiological SciencesUniversity Medical SchoolNewcastle upon TyneUK

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