CFTR Chloride Channels and Pancreatic Ductal Bicarbonate Secretion
The main function of pancreatic duct cells is to secrete a HC03--rich isotonic fluid (Fig. 1). This secretion flushes digestive enzymes, secreted by acinar cells located at the termini of the smallest ducts, along the ductal tree and into the duodenum (Fig. 1). It also neutralises acid chyme entering the duodenum from the stomach and thus helps to create the correct luminal environment for the digestion of food in the gut (Case amp; Argent, 1993: Argent amp; Case, 1994).
KeywordsCystic Fibrosis Cystic Fibrosis Transmembrane Conductance Regulator Duct Cell Chloride Channel Apical Plasma Membrane
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- Argent BE, Case RM. (1994). Pancreatic ducts: cellular mechanism and control of bicarbonate secretion. In: Johnson, LR, ed.Physiology of the Gastrointestinal Tract. Third Edition, New York: Raven Press, (in press).Google Scholar
- Case RM, Argent BE. (1993). Pancreatic duct cell secretion. Control and mechanisms of transport. In: Go VLW, Di Magno E, Gardner J, Lebenthal E, Reber H, Scheele G, eds.The Pancreas: Biology, Pathobiology and Disease, 2nd Edition, New York: Raven Press, 301–350.Google Scholar
- Gray MA, Winpenny JP, Porteous DJ, et al. (1994). CFTR and calcium-activated chloride currents in pancreatic duct cells of a transgenic CF mouse.Am. J. Physiol, (in press).Google Scholar
- Lingard JM, Al-Nakkash L, Argent BE. (1994). Acetylcholine, ATP, bombesin and cholecystokinin stimulate125I efflux from a human pancreatic adenocarcinoma cell line (BxPC-3).Pancreas(in press).Google Scholar
- Plant S, Gray MA, Argent BE. (1993). Ionomycin-activated chloride conductance in isolated rat pancreatic duct cells.J. Physiol.459: 239 P.Google Scholar