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Dynamics of Nucleic Acids and Nucleic Acid:Protein Complexes

  • Lennart Nilsson
Part of the Springer Series in Synergetics book series (SSSYN, volume 65)

Abstract

Molecular dynamics simulations can shed light on subnanosecond phenomena in nucleic acids interacting with proteins. Results from studies of Ribonuclease T1, the glucocortoid receptor DNA binding domain, and short model nucleotides are reported, and compared to experimental NMR and fluorescence data. Events occurring on different timescales will be discussed, together with an analysis of the the role of water, especially in the interface between protein and DNA.

Keywords

Glucocorticoid Receptor Free Energy Perturbation Half Site EcoRI Endonuclease Generalize Order Parameter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Lennart Nilsson

There are no affiliations available

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