Abstract
Ion channels are integral membrane proteins that form aqueous pores, which span the lipid bilayer moiety of biological membranes and provide for highly selective transfer of ions across the membrane. Ion transfer through the pore can occur at very high rates, and it is possible to use electrophysiological measuring techniques to record the function of single channels in real time. Ion channels are therefore useful for examining many aspects of macromolecular dynamics. The control of channel function is due to transitions between different channel states (conformations). The distribution between these states is determined by the channel’s intrinsic characteristics and by its interactions with the (membrane) environment, neither of which are well understood. We show, using the well-characterized gramicidin A channel as an example, that membrane control of channel function can be rationalized by considering the energetics of channel-bilayer interactions.
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Andersen, O.S., Lundbæk, J.A., Girshman, J. (1995). Channel Function and Channel-Lipid Bilayer Interactions. In: Mosekilde, E., Mouritsen, O.G. (eds) Modelling the Dynamics of Biological Systems. Springer Series in Synergetics, vol 65. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79290-8_7
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