Abstract
Multiple myeloma is a progressive and fatal disease characterized by the accumulation of malignant plasma cells in the bone marrow. Although the cause of myeloma remains unknown, interleukin 6 (IL-6) has been demonstrated to be a primary growth factor for malignant plasma cells in vitro [1, 2]. Elevated levels of IL-6 in myelomatous bone marrow and a direct correlation of IL-6 levels with disease severity suggest that IL-6 may be a crucial factor for tumor expansion in vivo as well [2, 3]. At the present time, it remains uncertain, however, as to whether paracrine or autocrine sources are responsible for the significant increases in IL-6 levels that occur during disease progression (reviewed in [4]).
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Westendorf, J.J. et al. (1995). Molecular and Biological Role of CD40 in Multiple Myeloma. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1994. Current Topics in Microbiology and Immunology, vol 194. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79275-5_9
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DOI: https://doi.org/10.1007/978-3-642-79275-5_9
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