Potential Role of CD28-B7 Interactions in the Growth of Myeloma Plasma Cells

  • J. Kornbluth
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 194)


Multiple myeloma is a malignancy of plasma cells. Patients with myeloma have associated immune deficiencies, including decreased numbers of B cells in the peripheral blood and corresponding decreased humoral responses. Myeloma patients also show significant alterations in T cell function. There are decreased numbers of CD4+ T cells while CD8+ T cells are normal to slightly increased [1,2].


Multiple Myeloma Myeloma Cell Myeloma Patient Myeloma Cell Line Myeloma Plasma Cell 
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  1. 1.
    Hoover RG, Kombluth J (1992) Immunoregulation of murine and human myeloma. Hematology/Oncology Clinics of North America 6: 407–424.PubMedGoogle Scholar
  2. 2.
    San Miguel JF et al (1992) Lymphoid subsets and prognostic factors in multiple myeloma. Br J Haematol 80: 305–309.PubMedCrossRefGoogle Scholar
  3. 3.
    Linsley PS, Ledbetter PS (1993) The role of the CD28 receptor during T cell responses to antigen. Ann Rev Immunol 11: 191–212.CrossRefGoogle Scholar
  4. 4.
    Harding FA, McArthur JG, Gross JA, Raulet DH, Allison JP (1992) CD28-mediated signalling costimulates murine T cells and prevents induction of anergy in T cell clones. Nature 356: 607–609.PubMedCrossRefGoogle Scholar
  5. 5.
    Hansen JA, Martin PJ, Nowinski RC (1980) Monoclonal antibodies identifying a novel T cell antigen of human lymphocytes. Immunogenetics 10: 247–260.CrossRefGoogle Scholar
  6. 6.
    Hara T, Fu SM, Hansen JA (1985) A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen). J Exp Med 161: 1513–1524.PubMedCrossRefGoogle Scholar
  7. 7.
    Kozbor D, Moretta A, Messner HA, Moretta L, Croce CM (1987) Tp44 molecules involved in antigen-independent T cell activation are expressed on human plasma cells. J Immunol 138: 4128–4132.PubMedGoogle Scholar
  8. 8.
    Linsley PS, Brady W, Grosmaire L, Aruffo A, Damle NK, Ledbetter JA (1991) Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J Exp Med 173: 721–730.PubMedCrossRefGoogle Scholar
  9. 9.
    Freeman GJ et al (1993) Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science 262: 907–909.PubMedCrossRefGoogle Scholar
  10. 10.
    Boussiotis VA, Freeman GJ, Gribben JG, Daley J, Gray G, Nadler LM (1993) Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T cell activation. Proc Natl Acad Sci USA 90: 11059–11063.PubMedCrossRefGoogle Scholar
  11. 11.
    Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA (1991) CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med 174: 561–569.PubMedCrossRefGoogle Scholar
  12. 12.
    Azuma M, Yssel H, Phillips JH, Spits H, Lanier LL (1993) Functional expression of B7/BB1 on activated T lymphocytes. J Exp Med 177: 845–850.PubMedCrossRefGoogle Scholar
  13. 13.
    Yokochi T, Holly RD, Clark EA (1982) B lymphoblastoid antigen (BB-1) expressed on Epstein-Barr virus activated B cell blasts, B lymphoid lines, and Burkitt’s lymphomas. J Immunol 128: 823–827.PubMedGoogle Scholar
  14. 14.
    Hata H, Xiao HQ, Petrucci MT, Woodliff, Epstein J (1993) Interleukin-6 gene expression in multiple myeloma: a characteristic of immature tumor cells. Blood 81: 3357–3364.PubMedGoogle Scholar
  15. 15.
    Kornbluth J, Spear B, Raab SS, Wilson DB (1985) Evidence for the role of class I and class II HLA antigens in the lytic function of a cloned line of human natural killer cells. J Immunol 134: 728–735.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • J. Kornbluth
    • 1
  1. 1.Departments of Medicine and Microbiology and Immunology, Arkansas Cancer Research CenterUniversity of Arkansas for Medical Sciences and McClellan VA Medical CenterLittle RockUSA

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