Potential Role of CD28-B7 Interactions in the Growth of Myeloma Plasma Cells

  • J. Kornbluth
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 194)


Multiple myeloma is a malignancy of plasma cells. Patients with myeloma have associated immune deficiencies, including decreased numbers of B cells in the peripheral blood and corresponding decreased humoral responses. Myeloma patients also show significant alterations in T cell function. There are decreased numbers of CD4+ T cells while CD8+ T cells are normal to slightly increased [1,2].


Lymphoma Tyrosine Polypeptide Myeloma Thymidine 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • J. Kornbluth
    • 1
  1. 1.Departments of Medicine and Microbiology and Immunology, Arkansas Cancer Research CenterUniversity of Arkansas for Medical Sciences and McClellan VA Medical CenterLittle RockUSA

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