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Potential Role of CD28-B7 Interactions in the Growth of Myeloma Plasma Cells

  • J. Kornbluth
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 194)

Abstract

Multiple myeloma is a malignancy of plasma cells. Patients with myeloma have associated immune deficiencies, including decreased numbers of B cells in the peripheral blood and corresponding decreased humoral responses. Myeloma patients also show significant alterations in T cell function. There are decreased numbers of CD4+ T cells while CD8+ T cells are normal to slightly increased [1,2].

Keywords

Multiple Myeloma Myeloma Cell Myeloma Patient Myeloma Cell Line Myeloma Plasma Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • J. Kornbluth
    • 1
  1. 1.Departments of Medicine and Microbiology and Immunology, Arkansas Cancer Research CenterUniversity of Arkansas for Medical Sciences and McClellan VA Medical CenterLittle RockUSA

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