Illegitimate Recombinations Between c-myc and Immunoglobulin Loci are Remodeled by Deletions in Mouse Plasmacytomas but not in Burkitt’s Lymphomas

  • J. R. Müller
  • S. Janz
  • M. Potter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 194)

Abstract

Recombinations between c-myc and immunoglobulin loci are a hallmark of Burkitt’s lymphomas and mouse plasmacytomas. Analyzing the fine structure of these illegitimate rearrangements has revealed differences between the recombinations in these two tumors. Recombinations are nearly reciprocal in Burkitt’s lymphomas, whereas in most BALB/c plasmacytomas large stretches of c-myc sequences have been deleted. The recombinations detected during preneoplastic development of plasmacytomas, in contrast, have most of the c-myc sequences retained on either one of the translocated chromosomes. We conclude that initial recombination structures are subjected to secondary changes in mouse plasmacytomas. In Burkitt’s lymphomas the primary recombination sequence is preserved in tumor cells.

Keywords

Lymphoma Recombination Plasmacytomas Pristane Rase 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Potter M, Wiener F (1992) Plasmacytomagenesis in mice: model of neoplastic development dependent upon chromosomal translocations. Carcinogenesis 13: 1681–1697PubMedCrossRefGoogle Scholar
  2. 2.
    Janz S, Müller J, Shaughnessy J, Potter M (1993) Detection of recombinations between c-myc and immunoglobulin switch a in murine plasma cell tumors and preneoplastic lesions by polymerase chain reaction. Proc Natl Acad Sci USA 90: 7361–7365PubMedCrossRefGoogle Scholar
  3. 3.
    Dalla-Favera R, Bregni M, Erikson J, Patterson D, Gallo RC, Croce CM (1982) Assignment of the human c-myc oncogene to the region of chromosome 8 which is translocated in Burkitt’s lymphoma cells. Proc Natl Acad Sci USA 79: 7824–7827PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • J. R. Müller
    • 1
  • S. Janz
    • 1
  • M. Potter
    • 1
  1. 1.Laboratory of Genetics, NCINIHUSA

Personalised recommendations