The Generation of Pvt-1/Ck Chimeric Transcripts as an Assay for Chromosomal Translocations in Mouse Plasmacytomas
A region of mouse chromosome 15 termed the c-Myc/Pvt-1 mega-gene locus is frequently associated with chromosomal breakpoints in a number of B-cell tumors including the mouse plasmacytoma and Burkitt’s lymphoma (for review see Potter 1990). In mouse plasmacytomas, one of two distinct types of chromosomal translocations can be found in nearly 100% of all tumors: 1). a t(12;15) translocation involving the Ig-H locus and c-Myc or 2). a t(6;15) translocation involving the Ig-k locus and Pvt-1. While the focus of such translocation events appears to be c-Myc, it is not yet clear whether Pvt-1 plays an active role in this process.
KeywordsLymphoma Codon Tryptophan Prep Editing
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