Abstract
B-chronic lymphocytic leukemia (B-CLL) is an accumulative disease of resting B lymphocytes (1). As the clonal expansion of B-CLL appears to reflect an extended survival of monoclonal B cells rather than an acceleration of their proliferative activity, the crucial problem of B-CLL biology becomes why these cells accumulate in the G0 phase of the cell cycle. Several data (reviewed in ref. 2) lead to conclude that B-CLL cell extended survival may be due both to a number of abnormalities that prevent an adequate mitogenic response and to the malignant cell’s inability to undergo apoptosis.
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© 1995 Springer-Verlag Berlin Heidelberg
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Gottardi, D., Alfarano, A., De Leo, A.M., Stacchini, A., Bergui, L., Caligaris-Cappio, F. (1995). Defective Apoptosis due to Bcl-2 Overexpression May Explain Why B-CLL Cells Accumulate in G0. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1994. Current Topics in Microbiology and Immunology, vol 194. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79275-5_35
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DOI: https://doi.org/10.1007/978-3-642-79275-5_35
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