Growth Factor Regulation of Cell Cycle Progression and Cell Fate Determination

  • Thomas W. Beck
  • Nancy S. Magnuson
  • Ulf R. Rapp
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 194)


The interaction between growth factors and their cell surface receptors initiates the cell cycle which under different physiological conditions can lead to cell growth, differentiation, survival or apoptosis (programmed cell death) (Figure 1). The sequence of events leading to cellular proliferation induced by growth factors involves activation of an intracellular signaling cascade resulting in induction of the expression of specific target genes in the nucleus which are sequentially and temporally expressed in defined classes, such as immediate early, delayed early and late. These gene products encode a large number of proteins which collaborate and indeed some are essential for driving cells through Gap1 (G1) of the cell cycle and into DNA synthesis (S phase). For successful entry into S phase, the growth factor must be in continuous contact with the cells. If however, the growth factor is removed prior to late G1 (R), cells will not commit to S phase and instead arrest in G1. This commitment step is controlled at least in part by certain members of a family of gene products, the cyclins, which are differentially regulated during the course of the cell cycle (Figure 1).


Early Gene Expression Growth Factor Regulation Promote Cell Cycle Progression Frederick Cancer Research Dominant Negative Version 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Thomas W. Beck
    • 1
  • Nancy S. Magnuson
    • 2
  • Ulf R. Rapp
    • 3
  1. 1.Frederick Cancer Research and Development CenterProgram Resources Inc./DyncorpFrederickUSA
  2. 2.Department of MicrobiologyWashington State UniversityPullmanUSA
  3. 3.Laboratory of Viral Carcinogenesis, National Cancer InstituteFrederick Cancer Research FacilityFrederickUSA

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