Abstract
Translocations or amplifications which activate members of the myc gene family are common in human cancer. c-Myc is a central regulator of normal cell proliferation and differentiation (Luscher and Eisenman, 1991; Marcu et al. 1992) and can induce apoptosis (Askew et al. 1991,1993; Evan et al. 1992; Bissonette et al. 1992; Shi et al. 1992). c-Myc is a transcription factor (Amati et al. 1992; Kretzner et al. 1992), however, the targets regulated by c-Myc which mediate its activities are not known. Here, we discuss the role of die ornithine decarboxylase (ODC) gene as a direct transcriptional target of c-Myc and demonstrate a role for ÒDC enzyme activity in c-Myc-induced apoptosis.
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© 1995 Springer-Verlag Berlin Heidelberg
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Packham, G., Cleveland, J.L. (1995). The Role of Ornithine Decarboxylase in c-Myc-induced Apoptosis. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1994. Current Topics in Microbiology and Immunology, vol 194. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79275-5_33
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DOI: https://doi.org/10.1007/978-3-642-79275-5_33
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