A New Form of Epstein-Barr Virus Latency in vivo
Epstein-Barr virus is a human herpesvirus that is associated with a number of tumors including Burkitts lymphoma, immunoblastic lymphoma, Hodgkins lymphoma, rare T cell lymphomas and nasopharyngeal carcinoma, suggesting a relatively broad tissue tropism for the virus in vivo [1,2]. Immunosuppression through allograft transplantation or HIV infection is known to promote the development of EBV positive tumors, particularly immunoblastic lymphomas. In vitro the virus has a strong tropism for B cells which it infects and causes to become latently infected, immortalized lymphoblasts. This is the only model system for EBV latency in a normal cell. These latently infected cells express 9 known latent proteins and high levels of cell surface markers, such as CD23, that are characteristically expressed on activated B cells [3,4].
KeywordsLymphoma Agarose Germinal Stein Lewin
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