A New Form of Epstein-Barr Virus Latency in vivo

  • E. Miyashita
  • D. A. Thorley-Lawson
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 194)


Epstein-Barr virus is a human herpesvirus that is associated with a number of tumors including Burkitts lymphoma, immunoblastic lymphoma, Hodgkins lymphoma, rare T cell lymphomas and nasopharyngeal carcinoma, suggesting a relatively broad tissue tropism for the virus in vivo [1,2]. Immunosuppression through allograft transplantation or HIV infection is known to promote the development of EBV positive tumors, particularly immunoblastic lymphomas. In vitro the virus has a strong tropism for B cells which it infects and causes to become latently infected, immortalized lymphoblasts. This is the only model system for EBV latency in a normal cell. These latently infected cells express 9 known latent proteins and high levels of cell surface markers, such as CD23, that are characteristically expressed on activated B cells [3,4].


Infected Cell Burkitts Lymphoma Virus Infected Cell Viral Burden Namalwa Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • E. Miyashita
    • 1
  • D. A. Thorley-Lawson
    • 1
  1. 1.Dept. of PathologyTufts University School of MedicineBostonUSA

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