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A New Form of Epstein-Barr Virus Latency in vivo

  • E. Miyashita
  • D. A. Thorley-Lawson
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 194)

Abstract

Epstein-Barr virus is a human herpesvirus that is associated with a number of tumors including Burkitts lymphoma, immunoblastic lymphoma, Hodgkins lymphoma, rare T cell lymphomas and nasopharyngeal carcinoma, suggesting a relatively broad tissue tropism for the virus in vivo [1,2]. Immunosuppression through allograft transplantation or HIV infection is known to promote the development of EBV positive tumors, particularly immunoblastic lymphomas. In vitro the virus has a strong tropism for B cells which it infects and causes to become latently infected, immortalized lymphoblasts. This is the only model system for EBV latency in a normal cell. These latently infected cells express 9 known latent proteins and high levels of cell surface markers, such as CD23, that are characteristically expressed on activated B cells [3,4].

Keywords

Infected Cell Burkitts Lymphoma Virus Infected Cell Viral Burden Namalwa Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • E. Miyashita
    • 1
  • D. A. Thorley-Lawson
    • 1
  1. 1.Dept. of PathologyTufts University School of MedicineBostonUSA

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