Classification of Mouse Lymphomas
We have applied the Kiel Classification of human lymphomas (Lennert and Feller 1992) to a series of mouse lymphomas (Table 1). In our survey, some came from other sources but most were from mice congenic for ecotropic murine leukemia virus induction loci and expressing high levels of endogenous leukemia viruses. Although such expression is associated with lymphoma development (Fredrickson et al. 1984), the proposed classification is considered generally applicable irrespective of etiology, since thymic lymphomas induced chemically with virus (Joshi and Frei 1970) or occurring in transgenic mice (Pattengale 1994) are morphologically similar. The classification attempts to provide a diagnosis based on morphology supported by molecular and immunologic analysis.
KeywordsMarginal Zone Marginal Zone Lymphoma Lymphoblastic Lymphoma Human Lymphoma Thymic Lymphoma
Unable to display preview. Download preview PDF.
- Fredricksoii IN, Morse H, Rowe W (1984) Spontaneous tumors of NFS mice congenic for ecotropic murine leukemia virus induction loci J Natl Cancer Inst 73: 521–524.Google Scholar
- Lautert K, Feller AC (1992) Histopathology of Non-Hodgkin’s Lymphomas (Based on the Updated Kiel Classification). Springer-Verlag, Berlin.Google Scholar
- Lukes RJ, Collins RD (1988) Tumors of the Hematopoietic System. Atlas of Tumor Pathology, Second Series, Fascicle 28 Armed Forces Institute of Pathology, Washington, DC.Google Scholar
- Okamoto K, Yamada Y, Ogawa MS, Toyokuni S, NakakuM Y, Ikeda H, Yoshida O, Hiai H (1994) Abnormal bone marrow B-cell differentiation in pre-B lymphoma-prone SL/Kh mice. Cancer Res 54: 399–402.Google Scholar
- Pattengale PK (1994) Tumours of the lympbohaematopoietic system. In: Turusov V, Mohr U (eds) Pathology of Tumours in Laboratory Animals, Tumors of the Mouse, 2nd edition. International Agency for Research cm Cancer (WHO) and International Life Sciences Institute, Lyon, pp 651–670.Google Scholar