Classification of Mouse Lymphomas
We have applied the Kiel Classification of human lymphomas (Lennert and Feller 1992) to a series of mouse lymphomas (Table 1). In our survey, some came from other sources but most were from mice congenic for ecotropic murine leukemia virus induction loci and expressing high levels of endogenous leukemia viruses. Although such expression is associated with lymphoma development (Fredrickson et al. 1984), the proposed classification is considered generally applicable irrespective of etiology, since thymic lymphomas induced chemically with virus (Joshi and Frei 1970) or occurring in transgenic mice (Pattengale 1994) are morphologically similar. The classification attempts to provide a diagnosis based on morphology supported by molecular and immunologic analysis.
KeywordsLymphoma Leukemia Hematoxylin Eosin Plasmacytoma
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