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Induction of Plasmacytomas in Genetically Susceptible Mice with Silicon Gels

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Mechanisms in B-Cell Neoplasia 1994

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 194))

Abstract

Silicone gels injected intraperitoneally into strains of mice related to BALB/c develop plasmacytomas in approximately the same numbers and with similar phenotypes as previously obtained with pristane. Silicone gels produce few side effects and are well tolerated for long periods. Silicone gels contain several components that are potentially biologically active: residual vinyl groups and platinum. Microscopic and histological evidence suggests the silicone gel is degraded over a long period of time. Preliminary studies with long chain liquid dimethylpolysiloxanes with viscosities of 1000 cSt and 12,500 cSt have not produced plasmacytomas as yet. The plasmacytomagenic action of the gel appears to be due to the release of liquids from the gel matrix.

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Authors and Affiliations

  1. Laboratory of Genetics, DCDBC, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    M. Potter & S. Morrison

  2. CBER, Food and Drug Administration, Bethesda, MD, USA

    F. Miller

Authors
  1. M. Potter
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  2. S. Morrison
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  3. F. Miller
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Editor information

Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute National Institutes of Health, Bldg. 37, Rm. 2B04, 20892, Bethesda, MD, USA

    Michael Potter M.D. (Chief) (Chief)

  2. Institute for Immunology, Grenzacherstr. 487, CH-4005, Basel, Switzerland

    Fritz Melchers (Director) (Director)

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© 1995 Springer-Verlag Berlin Heidelberg

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Potter, M., Morrison, S., Miller, F. (1995). Induction of Plasmacytomas in Genetically Susceptible Mice with Silicon Gels. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1994. Current Topics in Microbiology and Immunology, vol 194. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79275-5_11

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  • DOI: https://doi.org/10.1007/978-3-642-79275-5_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79277-9

  • Online ISBN: 978-3-642-79275-5

  • eBook Packages: Springer Book Archive

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