Abstract
The term shock is used to describe a clinical syndrome caused by inadequate delivery of nutrients, including oxygen, to the tissues. Even though shock may be manifested by generalized physiologic derangements, the pathophysiology takes place at the cellular level. In victims of trauma inadequate cellular perfusion can be attributed to hypovolemia from blood loss (hemorrhage), increased microvascular permeability, or redistribution of intravascular volume in the capacitance vessels [1]. The end result is a vicious cycle of oxygen debt leading to metabolic acidosis, cellular dysfunction, and ultimately cellular death [2].
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Mondy, J.S., Blaisdell, F.W. (1995). Volume Infusion in Traumatic Shock. In: Goris, R.J.A., Trentz, O. (eds) The Integrated Approach to Trauma Care. Update in Intensive Care and Emergency Medicine, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79272-4_8
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DOI: https://doi.org/10.1007/978-3-642-79272-4_8
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