Renal Epithelial Repair After Acute Tubular Necrosis

  • J. C. Lieske
  • F. G. Toback
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 20)

Abstract

The mortality rate of acute renal failure (ARF) remains unchanged despite the advent of dialysis, and it is the most costly condition amongst patients hospitalized with kidney disease [1]. Thus, measures to speed recovery of the injured kidney could have a significant impact on medical care. Cellular proliferation is often a prominent feature in the regenerating nephron, despite the systemic catabolic milieu [2–5]. Studies during the past 40 years have identified some of the factors that could mediate recovery and proliferation of epithelial cells in this setting. Better definition of these factors may eventually provide the physician with knowledge necessary to alter the local environment of tubular epithelial cells to speed recovery of renal function. This chapter will review some of what is known about factors that regulate cellular repair and regeneration after acute renal injury.

Keywords

Migration Ischemia Angiotensin Luminal Cytosol 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • J. C. Lieske
  • F. G. Toback

There are no affiliations available

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