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Zelluläre Biologie von Erythropoietin

  • Conference paper
Elektive Chirurgie

Part of the book series: Innovative Aspekte der klinischen Medizin ((KLIN MED,volume 3))

  • 17 Accesses

Zusammenfassung

Wie viele biologische Größen wird die Neubildungsrate der roten Blutkörperchen durch einen negativen Rückkopplungsmechanismus gesteuert, der sie normalerweise in engen Grenzen konstant hält oder an Veränderungen des Bedarfs anpaßt (Abb. 1). Schlüsselelement in diesem Regelkreis ist das Hormon Erythropoietin (EPO) [10, 19, 27]. EPO stimuliert die Bildung von Erythrozyten im Knochenmark. Seine Konzentration hängt ab vom peripheren Sauerstoffangebot, das seinerseits im wesentlichen durch die Zahl der zirkulierenden roten Blutzellen und deren Hämoglobingehalt bestimmt wird. Darüber hinaus beeinflussen die pulmonale Sauerstoffsättigung des Hämoglobins und seine Sauerstoffbindungsfähigkeit sowie die Hämodynamik das Sauerstoffangebot an die Gewebe. Bei einer Reduktion der Sauerstoffversorgung kommt es unabhängig von der Ursache zu einem Anstieg der EPO-Konzentration im Blutplasma und damit in der Regel zu einer Steigerung der Erythropoiese, während ein inadäquat erhöhtes Sauerstoffangebot die EPO-Spiegel und in der Folge die Erythropoiese supprimiert.

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Authors
  1. K.-U. Eckardt
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Editors and Affiliations

  1. Institut für Anästhesiologie und Operative Intensivmedizin, Klinikum Mannheim, Teodor-Kutzer-Ufer 1, 68167, Mannheim, Deutschland

    K. van Ackern

  2. Transfusionszentrum, III. Medizinischen Universitätsklinikum, Klinikum Großhadern, Marchioninistraße 15, 81377, München, Deutschland

    W. Mempel

  3. Abteilung für Chirurgie und Chirurgische Onkologie, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, Lindenberger Weg 80, 13122, Berlin, Deutschland

    P. Schlag

  4. Forschung Klinik, Nephrologie/Onkologie, Boehringer Mannheim GmbH, Sandhofer Straße 116, 68305, Mannheim, Deutschland

    P. Scigalla

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© 1994 Springer-Verlag Berlin Heidelberg

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Eckardt, KU. (1994). Zelluläre Biologie von Erythropoietin. In: van Ackern, K., Mempel, W., Schlag, P., Scigalla, P. (eds) Elektive Chirurgie. Innovative Aspekte der klinischen Medizin, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79238-0_4

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  • DOI: https://doi.org/10.1007/978-3-642-79238-0_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-58388-2

  • Online ISBN: 978-3-642-79238-0

  • eBook Packages: Springer Book Archive

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